Encenicline has been investigated for the treatment of Cognition, Schizophrenia, Alzheimer's Disease, Cardiac Repolarization, and Central Nervous System Diseases.
- Mechanism
- Curator reviewed
Encenicline, a selective, orally active, alpha 7 Nicotinic Acetylcholine Receptor agonist (alpha 7 NAchR agonist). Encenicline may have a similar mechanism of action to GTS-21. Auditory sensory gating, a biological measurement of the ability to suppress the evoked response to the second of two auditory stimuli, is diminished in people with schizophrenia. Deficits in sensory gating are associated with attentional impairment, and may contribute to cognitive symptoms and perceptual disturbances. This inhibitory process, which involves the alpha(7) nicotinic receptor mediated release of gamma-aminobutyric acid (GABA) by hippocampal interneurons, represents a potential new target for therapeutic intervention in schizophrenia.
- Formula / weight
- C16H17ClN2OS · 320.84 g/mol (avg)
- Code names
- EVP-6124 · MT-4666
Resolves to
SSRDSYXGYPJKRR-ZDUSSCGKSA-NSMILESClC1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1CN2CCC1CC2What you can answer from here — as of September 16, 2026
Which drugs share a target with Encenicline, and which of those have an active Phase 3 trial?
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