Dementia

Also known as: Dementias / Dementia Syndromes / Dementia (disorder) / Dementia NOS / Amentia / Dementia arising in the senium AND/OR presenium (disorder) / [X] Dementia: [unspecif] or [presenile NOS (including presenile psychosis NOS)] or [primary degenerative NOS] or [senile NOS (including senile psychosis NOS)] or [senile depressed or paranoid type] / [X]Unspecified dementia (disorder) / Presenile dementia NOS

Drug	Drug Name	Drug Description
DB00656	Trazodone	A serotonin uptake inhibitor used to treat major depressive disorder.
DB00831	Trifluoperazine	A phenothiazine used to treat depression, anxiety, and agitation.
DB00246	Ziprasidone	An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.

Drug	Drug Name	Target	Type
DB00656	Trazodone	5-hydroxytryptamine receptor 2A	target
DB00656	Trazodone	Sodium-dependent serotonin transporter	target
DB00656	Trazodone	Alpha-1A adrenergic receptor	target
DB00656	Trazodone	Alpha-2A adrenergic receptor	target
DB00656	Trazodone	Histamine H1 receptor	target
DB00656	Trazodone	5-hydroxytryptamine receptor 1A	target
DB00656	Trazodone	Cytochrome P450 2D6	enzyme
DB00656	Trazodone	Cytochrome P450 3A4	enzyme
DB00656	Trazodone	5-hydroxytryptamine receptor 2C	target
DB00656	Trazodone	Cytochrome P450 3A5	enzyme
DB00656	Trazodone	Cytochrome P450 3A7	enzyme
DB00656	Trazodone	P-glycoprotein 1	transporter
DB00656	Trazodone	5-hydroxytryptamine receptor 1C	target
DB00831	Trifluoperazine	Dopamine D2 receptor	target
DB00831	Trifluoperazine	Alpha-1A adrenergic receptor	target
DB00831	Trifluoperazine	Neuron-specific vesicular protein calcyon	target
DB00831	Trifluoperazine	Xanthine dehydrogenase/oxidase	enzyme
DB00831	Trifluoperazine	UDP-glucuronosyltransferase 1-4	enzyme
DB00831	Trifluoperazine	Cytochrome P450 1A2	enzyme
DB00831	Trifluoperazine	P-glycoprotein 1	transporter
DB00831	Trifluoperazine	Calmodulin	target
DB00831	Trifluoperazine	Troponin C, slow skeletal and cardiac muscles	target
DB00831	Trifluoperazine	Protein S100-A4	target
DB00246	Ziprasidone	Alpha-1A adrenergic receptor	target
DB00246	Ziprasidone	Dopamine D2 receptor	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 2C	target
DB00246	Ziprasidone	Dopamine D3 receptor	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 1A	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 1D	target
DB00246	Ziprasidone	Histamine H1 receptor	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 2A	target
DB00246	Ziprasidone	Dopamine D4 receptor	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 7	target
DB00246	Ziprasidone	Cytochrome P450 3A4	enzyme
DB00246	Ziprasidone	Alpha-2A adrenergic receptor	target
DB00246	Ziprasidone	Alpha-1B adrenergic receptor	target
DB00246	Ziprasidone	Alpha-2B adrenergic receptor	target
DB00246	Ziprasidone	Alpha-2C adrenergic receptor	target
DB00246	Ziprasidone	Dopamine D1 receptor	target
DB00246	Ziprasidone	Dopamine D5 receptor	target
DB00246	Ziprasidone	Muscarinic acetylcholine receptor M1	target
DB00246	Ziprasidone	Muscarinic acetylcholine receptor M2	target
DB00246	Ziprasidone	Muscarinic acetylcholine receptor M3	target
DB00246	Ziprasidone	Muscarinic acetylcholine receptor M4	target
DB00246	Ziprasidone	Muscarinic acetylcholine receptor M5	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 1B	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 1E	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 6	target
DB00246	Ziprasidone	Aldehyde oxidase	enzyme
DB00246	Ziprasidone	Serum albumin	carrier
DB00246	Ziprasidone	P-glycoprotein 1	transporter
DB00246	Ziprasidone	Alpha-1-acid glycoprotein 1	carrier
DB00246	Ziprasidone	5-hydroxytryptamine 3 receptor	target
DB00246	Ziprasidone	5-hydroxytryptamine receptor 5A	target

Drug	Drug Name	Phase	Status	Count
DB00747	Scopolamine	0	Completed	1
DB06616	Bosutinib	1	Enrolling by Invitation	1
DB00843	Donepezil	1	Completed	2
DB00843	Donepezil	1	Terminated	1
DB00783	Estradiol	1	Completed	1
DB09148	Florbetaben (18F)	1	Recruiting	1
DB15120	GSK-239512	1	Completed	1
DB06655	Liraglutide	1	Completed	1
DB00186	Lorazepam	1	Completed	1
DB11910	MK-0249	1	Terminated	1
DB01224	Quetiapine	1	Completed	1
DB00747	Scopolamine	1	Completed	1
DB01104	Sertraline	1	Completed	1
DB00313	Valproic acid	1	Unknown Status	1
DB08826	Deferiprone	1 / 2	Recruiting	1
DB00633	Dexmedetomidine	1 / 2	Completed	1
DB00316	Acetaminophen	2	Completed	1
DB00083	Botulinum toxin type A	2	Completed	1
DB06247	CX516	2	Completed	1
DB09061	Cannabidiol	2	Not Yet Recruiting	1
DB09061	Cannabidiol	2	Recruiting	1
DB00215	Citalopram	2	Completed	1
DB00633	Dexmedetomidine	2	Terminated	1
DB16647	Donanemab	2	Active Not Recruiting	1
DB00470	Dronabinol	2	Completed	2
DB11726	Encenicline	2	Withdrawn	1
DB08162	Fasudil	2	Completed	1
DB06138	IRL-1620	2	Completed	1
DB16213	Ladostigil	2	Completed	2
DB14009	Medical Cannabis	2	Completed	2
DB01043	Memantine	2	Completed	1
DB00331	Metformin	2	Completed	1
DB12969	Methylinositol	2	Completed	2
DB09220	Nicorandil	2	Recruiting	1
DB04870	Oleoyl-estrone	2	Terminated	1
DB01367	Rasagiline	2	Completed	1
DB00734	Risperidone	2	Completed	1
DB00989	Rivastigmine	2	Unknown Status	1
DB01656	Roflumilast	2	Completed	1
DB05271	Rotigotine	2	Active Not Recruiting	1
DB00316	Acetaminophen	2 / 3	Completed	1
DB00921	Buprenorphine	2 / 3	Completed	1
DB00843	Donepezil	2 / 3	Not Yet Recruiting	1
DB12034	Gantenerumab	2 / 3	Completed	1
DB12034	Gantenerumab	2 / 3	Recruiting	1
DB12034	Gantenerumab	2 / 3	Suspended	1
DB14580	Lecanemab	2 / 3	Recruiting	2
DB00351	Megestrol acetate	2 / 3	Terminated	1
DB00295	Morphine	2 / 3	Completed	1
DB00230	Pregabalin	2 / 3	Completed	1
DB11756	Solanezumab	2 / 3	Completed	1
DB11756	Solanezumab	2 / 3	Recruiting	1
DB00659	Acamprosate	3	Terminated	1
DB06594	Agomelatine	3	Terminated	1
DB00404	Alprazolam	3	Terminated	1
DB06288	Amisulpride	3	Terminated	1
DB00321	Amitriptyline	3	Terminated	1
DB01238	Aripiprazole	3	Completed	1
DB01238	Aripiprazole	3	Terminated	1
DB12867	Benperidol	3	Terminated	1
DB00810	Biperiden	3	Terminated	1
DB01558	Bromazepam	3	Terminated	1
DB12401	Bromperidol	3	Terminated	1
DB09017	Brotizolam	3	Terminated	1
DB01156	Bupropion	3	Terminated	1
DB00490	Buspirone	3	Terminated	1
DB00564	Carbamazepine	3	Terminated	1
DB01563	Chloral hydrate	3	Terminated	1
DB01239	Chlorprothixene	3	Terminated	1
DB00215	Citalopram	3	Completed	1
DB00215	Citalopram	3	Terminated	1
DB00349	Clobazam	3	Terminated	1
DB06470	Clomethiazole	3	Terminated	1
DB01242	Clomipramine	3	Terminated	1
DB01068	Clonazepam	3	Terminated	1
DB00363	Clozapine	3	Terminated	1
DB00633	Dexmedetomidine	3	Recruiting	2
DB00829	Diazepam	3	Terminated	1
DB01075	Diphenhydramine	3	Terminated	1
DB16647	Donanemab	3	Recruiting	1
DB00843	Donepezil	3	Completed	3
DB00843	Donepezil	3	Terminated	1
DB01142	Doxepin	3	Terminated	1
DB00476	Duloxetine	3	Terminated	1
DB11726	Encenicline	3	Terminated	3
DB01175	Escitalopram	3	Recruiting	1
DB01175	Escitalopram	3	Terminated	1
DB09149	Florbetapir (18F)	3	Unknown Status	1
DB00472	Fluoxetine	3	Terminated	1
DB00875	Flupentixol	3	Terminated	1
DB00623	Fluphenazine	3	Terminated	1
DB00690	Flurazepam	3	Terminated	1
DB04842	Fluspirilene	3	Terminated	1
DB15058	Flutemetamol	3	Terminated	1
DB09151	Flutemetamol (18F)	3	Terminated	1
DB00176	Fluvoxamine	3	Terminated	1
DB00996	Gabapentin	3	Terminated	1
DB00674	Galantamine	3	Completed	10
DB00674	Galantamine	3	Terminated	1
DB01381	Ginkgo biloba	3	Completed	2
DB00502	Haloperidol	3	Terminated	1
DB00557	Hydroxyzine	3	Terminated	1
DB00458	Imipramine	3	Terminated	1
DB06218	Lacosamide	3	Terminated	1
DB00555	Lamotrigine	3	Terminated	1
DB01202	Levetiracetam	3	Terminated	1
DB14509	Lithium carbonate	3	Terminated	1
DB00186	Lorazepam	3	Terminated	1
DB13872	Lormetazepam	3	Terminated	1
DB00934	Maprotiline	3	Terminated	1
DB01065	Melatonin	3	Terminated	1
DB09224	Melperone	3	Terminated	1
DB01043	Memantine	3	Terminated	1
DB01403	Methotrimeprazine	3	Terminated	1
DB06148	Mianserin	3	Terminated	1
DB00683	Midazolam	3	Terminated	1
DB00370	Mirtazapine	3	Completed	1
DB00370	Mirtazapine	3	Terminated	1
DB01171	Moclobemide	3	Terminated	1
DB00699	Nicergoline	3	Terminated	1
DB01595	Nitrazepam	3	Terminated	1
DB00540	Nortriptyline	3	Terminated	1
DB00334	Olanzapine	3	Terminated	1
DB12930	Opipramol	3	Terminated	1
DB00842	Oxazepam	3	Terminated	1
DB00776	Oxcarbazepine	3	Terminated	1
DB01267	Paliperidone	3	Terminated	1
DB00715	Paroxetine	3	Terminated	1
DB12710	Perazine	3	Terminated	1
DB00850	Perphenazine	3	Completed	1
DB00850	Perphenazine	3	Terminated	1
DB01174	Phenobarbital	3	Terminated	1
DB00252	Phenytoin	3	Terminated	1
DB01100	Pimozide	3	Terminated	1
DB09286	Pipamperone	3	Terminated	1
DB09210	Piracetam	3	Terminated	1
DB00230	Pregabalin	3	Terminated	1
DB01069	Promethazine	3	Terminated	1
DB12958	Prothipendyl	3	Terminated	1
DB13084	Pyritinol	3	Terminated	1
DB01224	Quetiapine	3	Terminated	2
DB00234	Reboxetine	3	Terminated	1
DB00734	Risperidone	3	Completed	4
DB00734	Risperidone	3	Terminated	2
DB00989	Rivastigmine	3	Completed	1
DB00989	Rivastigmine	3	Terminated	1
DB06144	Sertindole	3	Terminated	1
DB01104	Sertraline	3	Terminated	1
DB00391	Sulpiride	3	Terminated	1
DB05289	Tarenflurbil	3	Completed	1
DB05289	Tarenflurbil	3	Terminated	1
DB00231	Temazepam	3	Terminated	1
DB00679	Thioridazine	3	Terminated	1
DB13025	Tiapride	3	Terminated	1
DB00273	Topiramate	3	Terminated	1
DB00302	Tranexamic acid	3	Recruiting	1
DB00752	Tranylcypromine	3	Terminated	1
DB00656	Trazodone	3	Terminated	1
DB00897	Triazolam	3	Terminated	1
DB00726	Trimipramine	3	Terminated	1
DB00313	Valproic acid	3	Terminated	2
DB00285	Venlafaxine	3	Terminated	1
DB00962	Zaleplon	3	Terminated	1
DB00246	Ziprasidone	3	Terminated	1
DB00425	Zolpidem	3	Terminated	1
DB01198	Zopiclone	3	Terminated	1
DB01624	Zuclopenthixol	3	Terminated	1
DB00316	Acetaminophen	4	Completed	2
DB00915	Amantadine	4	Withdrawn	1
DB01238	Aripiprazole	4	Active Not Recruiting	1
DB01238	Aripiprazole	4	Completed	1
DB01076	Atorvastatin	4	Recruiting	1
DB00921	Buprenorphine	4	Completed	1
DB01156	Bupropion	4	Active Not Recruiting	1
DB00215	Citalopram	4	Completed	2
DB14726	Dabigatran	4	Completed	1
DB01576	Dextroamphetamine	4	Completed	1
DB00514	Dextromethorphan	4	Completed	1
DB00843	Donepezil	4	Completed	2
DB00843	Donepezil	4	Unknown Status	2
DB00476	Duloxetine	4	Completed	1
DB00625	Efavirenz	4	Completed	1
DB01175	Escitalopram	4	Completed	3
DB00674	Galantamine	4	Completed	1
DB00674	Galantamine	4	Unknown Status	1
DB04864	Huperzine A	4	Unknown Status	1
DB05510	Huperzine A	4	Unknown Status	1
DB00956	Hydrocodone	4	Completed	1
DB09420	Iodide I-123	4	Enrolling by Invitation	1
DB08824	Ioflupane I-123	4	Enrolling by Invitation	1
DB01221	Ketamine	4	Unknown Status	1
DB00709	Lamivudine	4	Completed	1
DB14509	Lithium carbonate	4	Active Not Recruiting	1
DB01065	Melatonin	4	Completed	1
DB01043	Memantine	4	Completed	2
DB01043	Memantine	4	Unknown Status	2
DB00422	Methylphenidate	4	Completed	3
DB00422	Methylphenidate	4	Terminated	1
DB00422	Methylphenidate	4	Withdrawn	1
DB08893	Mirabegron	4	Unknown Status	1
DB00238	Nevirapine	4	Completed	1
DB00393	Nimodipine	4	Completed	1
DB00540	Nortriptyline	4	Active Not Recruiting	1
DB00334	Olanzapine	4	Completed	3
DB00715	Paroxetine	4	Completed	1
DB00457	Prazosin	4	Recruiting	1
DB00818	Propofol	4	Unknown Status	1
DB13331	Pyrithyldione	4	Completed	1
DB01224	Quetiapine	4	Completed	2
DB01224	Quetiapine	4	Withdrawn	1
DB00908	Quinidine	4	Completed	1
DB00734	Risperidone	4	Completed	4
DB00734	Risperidone	4	Unknown Status	1
DB01104	Sertraline	4	Completed	1
DB01236	Sevoflurane	4	Unknown Status	1
DB01591	Solifenacin	4	Unknown Status	1
DB00300	Tenofovir disoproxil	4	Completed	1
DB00313	Valproic acid	4	Completed	1
DB00313	Valproic acid	4	Withdrawn	1
DB00285	Venlafaxine	4	Completed	1
DB09068	Vortioxetine	4	Completed	1
DB00682	Warfarin	4	Completed	1
DB00495	Zidovudine	4	Completed	1
DB00945	Acetylsalicylic acid	Not Available	Active Not Recruiting	1
DB00051	Adalimumab	Not Available	Completed	1
DB00297	Bupivacaine	Not Available	Active Not Recruiting	1
DB00482	Celecoxib	Not Available	Completed	1
DB08904	Certolizumab pegol	Not Available	Completed	1
DB00286	Conjugated estrogens	Not Available	Completed	1
DB01189	Desflurane	Not Available	Completed	1
DB00843	Donepezil	Not Available	Completed	3
DB00843	Donepezil	Not Available	Terminated	1
DB00783	Estradiol	Not Available	Completed	1
DB00005	Etanercept	Not Available	Completed	1
DB00813	Fentanyl	Not Available	Active Not Recruiting	1
DB09148	Florbetaben (18F)	Not Available	Completed	1
DB09148	Florbetaben (18F)	Not Available	Recruiting	1
DB09149	Florbetapir (18F)	Not Available	Completed	1
DB15058	Flutemetamol	Not Available	Unknown Status	1
DB09151	Flutemetamol (18F)	Not Available	Unknown Status	1
DB00996	Gabapentin	Not Available	Completed	1
DB00674	Galantamine	Not Available	Completed	3
DB00674	Galantamine	Not Available	Terminated	1
DB01381	Ginkgo biloba	Not Available	Completed	1
DB06674	Golimumab	Not Available	Completed	1
DB00065	Infliximab	Not Available	Completed	1
DB00753	Isoflurane	Not Available	Active Not Recruiting	1
DB14566	Lavender oil	Not Available	Unknown Status	1
DB00603	Medroxyprogesterone acetate	Not Available	Completed	1
DB01043	Memantine	Not Available	Completed	2
DB01043	Memantine	Not Available	Unknown Status	1
DB00563	Methotrexate	Not Available	Completed	1
DB00370	Mirtazapine	Not Available	Completed	1
DB00699	Nicergoline	Not Available	Completed	1
DB06690	Nitrous oxide	Not Available	Completed	1
DB09140	Oxygen	Not Available	Completed	1
DB09210	Piracetam	Not Available	Completed	1
DB00396	Progesterone	Not Available	Completed	1
DB00818	Propofol	Not Available	Active Not Recruiting	1
DB00818	Propofol	Not Available	Completed	2
DB00734	Risperidone	Not Available	Completed	1
DB00989	Rivastigmine	Not Available	Terminated	1
DB06140	SUVN-502	Not Available	No Longer Available	1
DB08839	Serotonin	Not Available	Recruiting	1
DB01236	Sevoflurane	Not Available	Active Not Recruiting	1
DB01236	Sevoflurane	Not Available	Completed	1
DB14329	Sunflower oil	Not Available	Unknown Status	1
DB00425	Zolpidem	Not Available	Completed	1