Chronic Myelomonocytic Leukemia

Also known as: Chronic Myelomonocytic Leukemia (CMML) / Chronic myelomonocytic leukaemia / CMML / Leukemia, Myelomonocytic, Chronic / Chronic myelomonocytic leukemia not having achieved remission / Chronic myelomonocytic leukemia (morphologic abnormality) / Chronic myelomonocytic leukemia (disorder) / Chronic myelomonocytic leukemia -RETIRED- / Chronic myelomonocytic leukemia [dup] (disorder)

Drug	Drug Name	Drug Description
DB00928	Azacitidine	A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.
DB15694	Cedazuridine	A cytidine deaminase inhibitor coadministered with the hypomethylating agent decitabine for the treatment of variable forms of myelodysplastic syndrome (MDS).
DB01262	Decitabine	A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression.

Drug	Drug Name	Target	Type
DB00928	Azacitidine	DNA (cytosine-5)-methyltransferase 1	target
DB00928	Azacitidine	Cytidine deaminase	enzyme
DB00928	Azacitidine	DNA	target
DB00928	Azacitidine	RNA	target
DB15694	Cedazuridine	Cytidine deaminase	target
DB01262	Decitabine	DNA	target
DB01262	Decitabine	DNA (cytosine-5)-methyltransferase 1	target
DB01262	Decitabine	Deoxycytidine kinase	enzyme
DB01262	Decitabine	UMP-CMP kinase	enzyme
DB01262	Decitabine	Nucleoside diphosphokinase	enzyme
DB01262	Decitabine	Cytidine deaminase	enzyme
DB01262	Decitabine	DNA (cytosine-5)-methyltransferase 3A	target
DB01262	Decitabine	DNA (cytosine-5)-methyltransferase 3B	target
DB01262	Decitabine	Sodium/nucleoside cotransporter 1	transporter
DB01262	Decitabine	Histone deacetylase	target

Drug	Drug Name	Phase	Status	Count
DB02594	2'-Deoxycytidine	1	Completed	1
DB05084	Abaloparatide	1	Completed	1
DB00928	Azacitidine	1	Active Not Recruiting	2
DB00928	Azacitidine	1	Completed	13
DB00928	Azacitidine	1	Recruiting	7
DB00928	Azacitidine	1	Terminated	2
DB06362	Becatecarin	1	Completed	1
DB05015	Belinostat	1	Completed	1
DB00112	Bevacizumab	1	Completed	1
DB17247	Bisantrene	1	Withdrawn	1
DB11752	Bryostatin 1	1	Completed	1
DB01008	Busulfan	1	Completed	1
DB01008	Busulfan	1	Recruiting	1
DB00958	Carboplatin	1	Active Not Recruiting	1
DB00958	Carboplatin	1	Completed	1
DB11059	Carboxymethylcellulose	1	Completed	2
DB15694	Cedazuridine	1	Completed	1
DB15694	Cedazuridine	1	Recruiting	3
DB15694	Cedazuridine	1	Withdrawn	1
DB01413	Cefepime	1	Completed	1
DB00631	Clofarabine	1	Completed	2
DB00631	Clofarabine	1	Terminated	1
DB00531	Cyclophosphamide	1	Active Not Recruiting	1
DB00531	Cyclophosphamide	1	Completed	2
DB00531	Cyclophosphamide	1	Terminated	2
DB00091	Cyclosporine	1	Completed	3
DB00987	Cytarabine	1	Completed	3
DB00987	Cytarabine	1	Withdrawn	1
DB17501	DSP107	1	Recruiting	1
DB01262	Decitabine	1	Completed	6
DB01262	Decitabine	1	Recruiting	3
DB01262	Decitabine	1	Withdrawn	2
DB12282	Defactinib	1	Recruiting	1
DB01248	Docetaxel	1	Completed	1
DB13874	Enasidenib	1	Completed	1
DB11841	Entinostat	1	Completed	1
DB00773	Etoposide	1	Completed	1
DB00099	Filgrastim	1	Completed	2
DB01073	Fludarabine	1	Active Not Recruiting	1
DB01073	Fludarabine	1	Completed	6
DB01073	Fludarabine	1	Recruiting	1
DB01073	Fludarabine	1	Suspended	1
DB01073	Fludarabine	1	Terminated	1
DB11978	Glasdegib	1	Completed	1
DB14017	H3B-8800	1	Active Not Recruiting	1
DB17293	Hiltonol	1	Completed	2
DB17548	IO-202	1	Recruiting	1
DB09053	Ibrutinib	1	Completed	1
DB00619	Imatinib	1	Completed	1
DB11659	Indium	1	Completed	1
DB06186	Ipilimumab	1	Completed	1
DB06186	Ipilimumab	1	Recruiting	1
DB12154	Itacitinib	1	Recruiting	1
DB12232	KRN-7000	1	Active Not Recruiting	1
DB00480	Lenalidomide	1	Completed	1
DB15148	Lenzilumab	1	Completed	1
DB14877	Lintuzumab	1	Completed	1
DB00123	Lysine	1	Completed	2
DB00179	Masoprocol	1	Terminated	1
DB00888	Mechlorethamine	1	Completed	1
DB01042	Melphalan	1	Active Not Recruiting	1
DB00688	Mycophenolate mofetil	1	Active Not Recruiting	1
DB00688	Mycophenolate mofetil	1	Completed	4
DB00688	Mycophenolate mofetil	1	Terminated	1
DB01024	Mycophenolic acid	1	Active Not Recruiting	1
DB09035	Nivolumab	1	Completed	1
DB01229	Paclitaxel	1	Completed	1
DB11697	Pacritinib	1	Withdrawn	1
DB06603	Panobinostat	1	Completed	1
DB11759	Pevonedistat	1	Completed	1
DB12008	Prexasertib	1	Completed	1
DB15185	Rasdegafusp alfa	1	Completed	2
DB14729	Rebeccamycin	1	Completed	1
DB00073	Rituximab	1	Completed	1
DB16322	Sabatolimab	1	Completed	1
DB00020	Sargramostim	1	Completed	1
DB00877	Sirolimus	1	Active Not Recruiting	1
DB00877	Sirolimus	1	Completed	1
DB09143	Sonidegib	1	Completed	1
DB14892	Spartalizumab	1	Completed	1
DB01268	Sunitinib	1	Completed	1
DB00864	Tacrolimus	1	Completed	1
DB00864	Tacrolimus	1	Terminated	1
DB14731	Tagraxofusp	1	Recruiting	1
DB06398	Tanespimycin	1	Completed	1
DB17166	Tapotoclax	1	Recruiting	1
DB00853	Temozolomide	1	Active Not Recruiting	1
DB12226	Terameprocol	1	Terminated	1
DB04960	Tipifarnib	1	Completed	1
DB01030	Topotecan	1	Active Not Recruiting	1
DB07232	Veliparib	1	Active Not Recruiting	2
DB11581	Venetoclax	1	Active Not Recruiting	2
DB11581	Venetoclax	1	Recruiting	3
DB12062	Volasertib	1	Completed	1
DB12062	Volasertib	1	Terminated	1
DB02546	Vorinostat	1	Completed	2
DB00041	Aldesleukin	1 / 2	Completed	2
DB00041	Aldesleukin	1 / 2	Unknown Status	1
DB17549	Alrizomadlin	1 / 2	Recruiting	1
DB00276	Amsacrine	1 / 2	Recruiting	1
DB11595	Atezolizumab	1 / 2	Active Not Recruiting	1
DB00928	Azacitidine	1 / 2	Active Not Recruiting	2
DB00928	Azacitidine	1 / 2	Completed	4
DB00928	Azacitidine	1 / 2	Recruiting	5
DB00928	Azacitidine	1 / 2	Unknown Status	1
DB00928	Azacitidine	1 / 2	Withdrawn	1
DB16383	Bexmarilimab	1 / 2	Recruiting	1
DB00188	Bortezomib	1 / 2	Not Yet Recruiting	1
DB01008	Busulfan	1 / 2	Completed	1
DB15694	Cedazuridine	1 / 2	Recruiting	1
DB00631	Clofarabine	1 / 2	Terminated	1
DB00531	Cyclophosphamide	1 / 2	Not Yet Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Recruiting	1
DB00091	Cyclosporine	1 / 2	Completed	3
DB00091	Cyclosporine	1 / 2	Suspended	1
DB00987	Cytarabine	1 / 2	Completed	1
DB00987	Cytarabine	1 / 2	Recruiting	1
DB00694	Daunorubicin	1 / 2	Completed	1
DB01262	Decitabine	1 / 2	Completed	1
DB01262	Decitabine	1 / 2	Recruiting	2
DB11687	E-6201	1 / 2	Terminated	1
DB18120	EP-0042	1 / 2	Recruiting	1
DB06210	Eltrombopag	1 / 2	Completed	1
DB11684	Eprenetapopt	1 / 2	Completed	1
DB11684	Eprenetapopt	1 / 2	Unknown Status	1
DB17554	FF-10501-01	1 / 2	Completed	1
DB00099	Filgrastim	1 / 2	Recruiting	1
DB01073	Fludarabine	1 / 2	Completed	4
DB01073	Fludarabine	1 / 2	Recruiting	1
DB01073	Fludarabine	1 / 2	Suspended	1
DB11918	Guadecitabine	1 / 2	Active Not Recruiting	1
DB11918	Guadecitabine	1 / 2	Completed	1
DB05381	Histamine	1 / 2	Unknown Status	1
DB01177	Idarubicin	1 / 2	Completed	1
DB00480	Lenalidomide	1 / 2	Unknown Status	1
DB00563	Methotrexate	1 / 2	Terminated	1
DB12431	Muplestim	1 / 2	Recruiting	1
DB00688	Mycophenolate mofetil	1 / 2	Completed	3
DB00688	Mycophenolate mofetil	1 / 2	Recruiting	2
DB00688	Mycophenolate mofetil	1 / 2	Suspended	1
DB15721	Natural Killer Cell	1 / 2	Completed	1
DB11697	Pacritinib	1 / 2	Completed	1
DB06603	Panobinostat	1 / 2	Completed	1
DB11759	Pevonedistat	1 / 2	Active Not Recruiting	1
DB12874	Quizartinib	1 / 2	Recruiting	1
DB12146	Rigosertib	1 / 2	Completed	1
DB06436	Semaxanib	1 / 2	Completed	1
DB01261	Sitagliptin	1 / 2	Not Yet Recruiting	1
DB00864	Tacrolimus	1 / 2	Recruiting	2
DB14731	Tagraxofusp	1 / 2	Recruiting	1
DB04942	Tamibarotene	1 / 2	Withdrawn	1
DB15232	Telaglenastat	1 / 2	Completed	1
DB17459	Therapeutic allogeneic lymphocytes	1 / 2	Completed	1
DB04960	Tipifarnib	1 / 2	Completed	2
DB11581	Venetoclax	1 / 2	Active Not Recruiting	1
DB11581	Venetoclax	1 / 2	Recruiting	4
DB11581	Venetoclax	1 / 2	Withdrawn	1
DB02546	Vorinostat	1 / 2	Active Not Recruiting	1
DB01955	1,4-Butanediol	2	Completed	1
DB17172	Activated natural killer cell therapy	2	Recruiting	1
DB11740	Adavosertib	2	Completed	1
DB08885	Aflibercept	2	Terminated	1
DB00087	Alemtuzumab	2	Completed	1
DB09312	Antilymphocyte immunoglobulin (horse)	2	Completed	2
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Completed	2
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Recruiting	1
DB01169	Arsenic trioxide	2	Completed	1
DB00928	Azacitidine	2	Active Not Recruiting	2
DB00928	Azacitidine	2	Completed	9
DB00928	Azacitidine	2	Recruiting	4
DB00928	Azacitidine	2	Terminated	2
DB00928	Azacitidine	2	Withdrawn	1
DB00394	Beclomethasone dipropionate	2	Completed	1
DB11782	Birinapant	2	Terminated	1
DB01008	Busulfan	2	Completed	6
DB01008	Busulfan	2	Not Yet Recruiting	1
DB01008	Busulfan	2	Recruiting	2
DB01008	Busulfan	2	Terminated	1
DB01008	Busulfan	2	Withdrawn	1
DB17465	CD-16 NK-92 cells	2	Recruiting	1
DB06168	Canakinumab	2	Recruiting	1
DB00958	Carboplatin	2	Active Not Recruiting	1
DB00958	Carboplatin	2	Completed	1
DB15694	Cedazuridine	2	Enrolling by Invitation	1
DB15694	Cedazuridine	2	Recruiting	2
DB00242	Cladribine	2	Recruiting	1
DB00631	Clofarabine	2	Active Not Recruiting	1
DB06189	Clofarabine	2	Active Not Recruiting	1
DB00631	Clofarabine	2	Completed	3
DB06189	Clofarabine	2	Completed	2
DB00631	Clofarabine	2	Recruiting	1
DB05239	Cobimetinib	2	Recruiting	1
DB09110	Coenzyme M	2	Not Yet Recruiting	1
DB15100	Cusatuzumab	2	Withdrawn	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	2
DB00531	Cyclophosphamide	2	Completed	8
DB00531	Cyclophosphamide	2	Not Yet Recruiting	1
DB00531	Cyclophosphamide	2	Recruiting	5
DB00531	Cyclophosphamide	2	Withdrawn	1
DB00091	Cyclosporine	2	Completed	5
DB00091	Cyclosporine	2	Recruiting	2
DB00091	Cyclosporine	2	Terminated	1
DB00091	Cyclosporine	2	Withdrawn	1
DB00987	Cytarabine	2	Completed	2
DB00987	Cytarabine	2	Recruiting	2
DB01254	Dasatinib	2	Completed	1
DB01254	Dasatinib	2	Terminated	1
DB00694	Daunorubicin	2	Recruiting	2
DB01262	Decitabine	2	Completed	6
DB01262	Decitabine	2	Enrolling by Invitation	1
DB01262	Decitabine	2	Recruiting	3
DB01262	Decitabine	2	Terminated	2
DB01262	Decitabine	2	Unknown Status	1
DB01609	Deferasirox	2	Terminated	1
DB00590	Doxazosin	2	Recruiting	1
DB12505	E-7820	2	Active Not Recruiting	1
DB06210	Eltrombopag	2	Completed	1
DB13874	Enasidenib	2	Active Not Recruiting	1
DB13874	Enasidenib	2	Recruiting	2
DB11841	Entinostat	2	Completed	2
DB00530	Erlotinib	2	Completed	1
DB00016	Erythropoietin	2	Completed	1
DB00099	Filgrastim	2	Completed	2
DB00099	Filgrastim	2	Recruiting	1
DB01073	Fludarabine	2	Active Not Recruiting	3
DB01073	Fludarabine	2	Completed	12
DB01073	Fludarabine	2	Not Yet Recruiting	1
DB01073	Fludarabine	2	Recruiting	4
DB01073	Fludarabine	2	Terminated	2
DB01073	Fludarabine	2	Withdrawn	1
DB00056	Gemtuzumab ozogamicin	2	Recruiting	1
DB11978	Glasdegib	2	Completed	1
DB11918	Guadecitabine	2	Active Not Recruiting	1
DB09054	Idelalisib	2	Terminated	1
DB00619	Imatinib	2	Completed	4
DB06186	Ipilimumab	2	Completed	1
DB02325	Isopropyl alcohol	2	Recruiting	1
DB12154	Itacitinib	2	Recruiting	1
DB00480	Lenalidomide	2	Active Not Recruiting	1
DB00480	Lenalidomide	2	Completed	3
DB00480	Lenalidomide	2	Unknown Status	1
DB00007	Leuprolide	2	Completed	1
DB00888	Mechlorethamine	2	Completed	1
DB00888	Mechlorethamine	2	Recruiting	1
DB01042	Melphalan	2	Active Not Recruiting	1
DB01042	Melphalan	2	Completed	3
DB01042	Melphalan	2	Not Yet Recruiting	1
DB01042	Melphalan	2	Recruiting	1
DB14123	Menthol	2	Completed	1
DB16620	Methopterin	2	Withdrawn	1
DB00563	Methotrexate	2	Completed	5
DB00563	Methotrexate	2	Terminated	1
DB00563	Methotrexate	2	Withdrawn	1
DB00959	Methylprednisolone	2	Completed	1
DB00688	Mycophenolate mofetil	2	Active Not Recruiting	1
DB00688	Mycophenolate mofetil	2	Completed	9
DB00688	Mycophenolate mofetil	2	Not Yet Recruiting	1
DB00688	Mycophenolate mofetil	2	Recruiting	3
DB00688	Mycophenolate mofetil	2	Terminated	1
DB01024	Mycophenolic acid	2	Active Not Recruiting	1
DB01024	Mycophenolic acid	2	Recruiting	1
DB15721	Natural Killer Cell	2	Recruiting	1
DB09035	Nivolumab	2	Completed	1
DB00904	Ondansetron	2	Completed	1
DB11697	Pacritinib	2	Terminated	1
DB11759	Pevonedistat	2	Completed	1
DB08910	Pomalidomide	2	Recruiting	1
DB08901	Ponatinib	2	Terminated	1
DB00073	Rituximab	2	Completed	1
DB00073	Rituximab	2	Recruiting	1
DB08877	Ruxolitinib	2	Active Not Recruiting	1
DB08877	Ruxolitinib	2	Terminated	1
DB14797	SEphB4-HSA	2	Terminated	1
DB16322	Sabatolimab	2	Recruiting	1
DB01399	Salsalate	2	Completed	1
DB00020	Sargramostim	2	Completed	1
DB00877	Sirolimus	2	Active Not Recruiting	1
DB00877	Sirolimus	2	Recruiting	1
DB00398	Sorafenib	2	Terminated	2
DB12118	Sotatercept	2	Completed	1
DB14892	Spartalizumab	2	Recruiting	1
DB01268	Sunitinib	2	Completed	1
DB01268	Sunitinib	2	Terminated	2
DB00864	Tacrolimus	2	Active Not Recruiting	2
DB00864	Tacrolimus	2	Completed	10
DB00864	Tacrolimus	2	Not Yet Recruiting	1
DB00864	Tacrolimus	2	Recruiting	2
DB00864	Tacrolimus	2	Terminated	1
DB00864	Tacrolimus	2	Withdrawn	1
DB14731	Tagraxofusp	2	Completed	1
DB06287	Temsirolimus	2	Completed	1
DB01041	Thalidomide	2	Completed	1
DB17459	Therapeutic allogeneic lymphocytes	2	Completed	1
DB04572	Thiotepa	2	Recruiting	1
DB04960	Tipifarnib	2	Completed	1
DB01030	Topotecan	2	Active Not Recruiting	1
DB11678	Treosulfan	2	Active Not Recruiting	1
DB11678	Treosulfan	2	Completed	1
DB11678	Treosulfan	2	Recruiting	1
DB11940	Triapine	2	Completed	1
DB03754	Tromethamine	2	Recruiting	1
DB07232	Veliparib	2	Active Not Recruiting	1
DB11581	Venetoclax	2	Completed	1
DB11581	Venetoclax	2	Recruiting	4
DB02546	Vorinostat	2	Active Not Recruiting	1
DB02546	Vorinostat	2	Completed	1
DB00041	Aldesleukin	3	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	3	Recruiting	1
DB00023	Asparaginase Escherichia coli	3	Completed	1
DB00928	Azacitidine	3	Active Not Recruiting	2
DB00928	Azacitidine	3	Completed	1
DB00928	Azacitidine	3	Not Yet Recruiting	1
DB01008	Busulfan	3	Completed	1
DB11348	Calcium Phosphate	3	Completed	1
DB15694	Cedazuridine	3	Completed	1
DB15694	Cedazuridine	3	Not Yet Recruiting	1
DB00531	Cyclophosphamide	3	Completed	1
DB00531	Cyclophosphamide	3	Recruiting	1
DB00531	Cyclophosphamide	3	Terminated	1
DB00987	Cytarabine	3	Completed	1
DB00694	Daunorubicin	3	Completed	1
DB01262	Decitabine	3	Completed	1
DB01262	Decitabine	3	Not Yet Recruiting	1
DB01234	Dexamethasone	3	Completed	1
DB00016	Erythropoietin	3	Active Not Recruiting	1
DB00773	Etoposide	3	Completed	1
DB00099	Filgrastim	3	Completed	1
DB01073	Fludarabine	3	Completed	1
DB11978	Glasdegib	3	Completed	1
DB11918	Guadecitabine	3	Completed	1
DB00741	Hydrocortisone	3	Completed	1
DB01177	Idarubicin	3	Completed	1
DB00480	Lenalidomide	3	Active Not Recruiting	1
DB06448	Lonafarnib	3	Terminated	1
DB00563	Methotrexate	3	Completed	1
DB00563	Methotrexate	3	Terminated	1
DB11759	Pevonedistat	3	Active Not Recruiting	1
DB12146	Rigosertib	3	Completed	2
DB16322	Sabatolimab	3	Active Not Recruiting	1
DB00352	Tioguanine	3	Completed	1
DB09312	Antilymphocyte immunoglobulin (horse)	Not Available	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	Not Available	Completed	1
DB00091	Cyclosporine	Not Available	Completed	2
DB00987	Cytarabine	Not Available	Completed	1
DB01073	Fludarabine	Not Available	Completed	3
DB00529	Foscarnet	Not Available	Completed	1
DB01004	Ganciclovir	Not Available	Completed	1
DB01177	Idarubicin	Not Available	Completed	1
DB00619	Imatinib	Not Available	Completed	1
DB14509	Lithium carbonate	Not Available	Completed	1
DB01042	Melphalan	Not Available	Completed	1
DB00688	Mycophenolate mofetil	Not Available	Completed	2
DB00039	Palifermin	Not Available	Completed	1
DB00175	Pravastatin	Not Available	Completed	1
DB01610	Valganciclovir	Not Available	Completed	1