This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Protamine is a heparin antagonist indicated in the treatment of heparin overdoses, to counteract heparins preoperatively, or during cardiac surgery and dialysis.
- Generic Name
- Protamine
- DrugBank Accession Number
- DB13700
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental, Investigational
- Synonyms
- Protamina
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Ingredient UNII CAS InChI Key Protamine hydrochloride 5URD19Y60H Not Available Not applicable
Categories
- ATC Codes
- V03AB14 — Protamine
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 72G3UY6T4N
- CAS number
- 9012-00-4
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- TITCK Product Information: Protamine hydrochloride for intravenous administration [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Anticoagulation / Cardiopulmonary Bypass / Surgery, Cardiac 1 4 Completed Treatment Atrial Fibrillation / Catheter Ablation 1 4 Completed Treatment Coagulation; Intravascular 1 4 Completed Treatment Type 2 Diabetes Mellitus 1 4 Not Yet Recruiting Prevention Valve Stenoses, Aortic 1 4 Unknown Status Treatment Anticoagulant Antagonist Toxicity 1 3 Completed Treatment Coronary Artery Bypass Grafting (CABG) / Surgery, Cardiac 1 3 Completed Treatment Type 2 Diabetes Mellitus 2 Not Available Completed Not Available Protamine Adverse Reaction / Protamine Allergy 1 Not Available Completed Treatment Bleeding 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection Intravenous 5000 IU/5ml Injection, solution Intravenous 1000 IU/ml Solution Intravenous 5000 IU Injection, solution Intravenous; Parenteral 50 MG/5ML - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at June 23, 2017 20:47 / Updated at May 29, 2021 18:12