Prothrombin

Details

Name
Prothrombin
Kind
protein
Synonyms
  • 3.4.21.5
  • Coagulation factor II
Gene Name
F2
UniProtKB Entry
P00734Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0016004|Prothrombin
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
Number of residues
622
Molecular Weight
70036.295
Theoretical pI
5.7
GO Classification
Functions
heparin binding / lipopolysaccharide binding / signaling receptor binding
Processes
antimicrobial humoral immune response mediated by antimicrobial peptide / cytolysis by host of symbiont cells / G protein-coupled receptor signaling pathway / ligand-gated ion channel signaling pathway / negative regulation of cytokine production involved in inflammatory response / neutrophil-mediated killing of gram-negative bacterium / positive regulation of cell population proliferation / positive regulation of insulin secretion / positive regulation of lipid kinase activity / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of protein localization to nucleus / positive regulation of receptor signaling pathway via JAK-STAT / regulation of cytosolic calcium ion concentration
Components
collagen-containing extracellular matrix
General Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Thrombin triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208)
Specific Function
calcium ion binding
Pfam Domain Function
Signal Regions
1-24
Transmembrane Regions
Not Available
Cellular Location
Secreted, extracellular space
Gene sequence
>lcl|BSEQ0016005|Prothrombin (F2)
ATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGC
CTTGTGCACAGCCAGCATGTGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGG
GTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTGGAGCGAGAGTGC
GTGGAGGAGACGTGCAGCTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACG
GATGTGTTCTGGGCCAAGTACACAGCTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTT
GCTGCATGTCTGGAAGGTAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTG
AACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCT
GAAATCAACTCCACTACCCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCC
GACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAA
TGCAGCATCCCTGTCTGTGGCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAA
GGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAG
TACCAGGGGCGCCTGGCGGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCA
CAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAAC
TTCTGCCGCAACCCAGACGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCT
GGCGACTTTGGGTACTGCGACCTCAACTATTGTGAGGAGGCCGTGGAGGAGGAGACAGGA
GATGGGCTGGATGAGGACTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTAC
CAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAGACTGTGGGCTGCGACCT
CTGTTCGAGAAGAAGTCGCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATC
GACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTGGCAGGTGATG
CTTTTCCGGAAGAGTCCCCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGG
GTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAAT
GACCTTCTGGTGCGCATTGGCAAGCACTCCCGCACCAGGTACGAGCGAAACATTGAAAAG
ATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGAC
CGGGACATTGCCCTGATGAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCT
GTGTGTCTGCCCGACAGGGAGACGGCAGCCAGCTTGCTCCAGGCTGGATACAAGGGGCGG
GTGACAGGCTGGGGCAACCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCC
AGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACC
CGGATCCGCATCACTGACAACATGTTCTGTGCTGGTTACAAGCCTGATGAAGGGAAACGA
GGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAGAGCCCCTTTAACAAC
CGCTGGTATCAAATGGGCATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATAT
GGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTT
GGAGAGTAG
Chromosome Location
11
Locus
11p11.2
External Identifiers
ResourceLink
UniProtKB IDP00734
UniProtKB Entry NameTHRB_HUMAN
GenBank Protein ID339641
GenBank Gene IDM17262
GeneCard IDF2
GenAtlas IDF2
HGNC IDHGNC:3535
PDB ID(s)1A2C, 1A3B, 1A3E, 1A46, 1A4W, 1A5G, 1A61, 1ABI, 1ABJ, 1AD8, 1AE8, 1AFE, 1AHT, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DWE, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1FPH, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAG, 1HAH, 1HAI, 1HAO, 1HAP, 1HBT, 1HDT, 1HGT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1IHT, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NO9, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1TBZ, 1THP, 1THR, 1THS, 1TMB, 1TMT, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UMA, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8W, 2C8X, 2C8Y, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH5, 2JH6, 2OD3, 2PGB, 2PGQ, 2PKS, 2PW8, 2R2M, 2THF, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZFQ, 2ZFR, 2ZG0, 2ZGB, 2ZGX, 2ZHE, 2ZHF, 2ZHQ, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DHK, 3DT0, 3DUX, 3E6P, 3EE0, 3EGK, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ1, 3JZ2, 3K65, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PMH, 3PO1, 3QDZ, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4AX9, 4AYV, 4AYY, 4AZ2, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4CH2, 4CH8, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4THN, 4UD9, 4UDW, 4UE7, 4UEH, 4UFD, 4UFE, 4UFF, 4UFG, 4YES, 5A2M, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 5DO4, 5E8E, 5EDK, 5EDM, 5EW1, 5EW2, 5GDS, 5GIM, 5JDU, 5JFD, 5JZY, 5L6N, 5MJT, 5MLS, 5MM6, 5NHU, 5TO3, 5Z5W, 5Z5X, 6BJR, 6C2W, 6EO6, 6EO7, 6EO8, 6EO9, 6V5T, 7KME, 7TPP, 8BWW, 8KME, 8UF7
KEGG IDhsa:2147
IUPHAR/Guide To Pharmacology ID2362
NCBI Gene ID2147
General References
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  5. Degen SJ, MacGillivray RT, Davie EW: Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin. Biochemistry. 1983 Apr 26;22(9):2087-97. [Article]
  6. Suzuki K, Moriyama M, Nakajima C, Kawamura K, Miyazawa K, Tsugawa R, Kikuchi N, Nagata K: Isolation and partial characterization of crystal matrix protein as a potent inhibitor of calcium oxalate crystal aggregation: evidence of activation peptide of human prothrombin. Urol Res. 1994;22(1):45-50. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Lepirudinapproved, withdrawnyestargetinhibitorDetails
Bivalirudinapproved, investigationalyestargetinhibitorDetails
Argatrobanapproved, investigationalyestargetinhibitorDetails
Menadioneapproved, nutraceuticalunknowntargetactivatorDetails
Proflavineapprovednotargetother/unknownDetails
4-Oxo-2-Phenylmethanesulfonyl-Octahydro-Pyrrolo[1,2-a]Pyrazine-6-Carboxylic Acid [1-(N-Hydroxycarbamimidoyl)-Piperidin-4-Ylmethyl]-AmideexperimentalunknowntargetDetails
gamma-carboxy-L-glutamic acidexperimentalyestargetinhibitorDetails
LysophosphotidylserineexperimentalunknowntargetDetails
Drotrecogin alfaapproved, investigational, withdrawnunknowntargetDetails
Coagulation Factor IX (Recombinant)approved, investigationalunknowntargetDetails
Ximelagatranapproved, investigational, withdrawnyestargetinhibitorDetails
N-{2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}-2-[2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL][1,3]OXAZOLO[4,5-C]PYRIDIN-4-AMINEexperimentalunknowntargetDetails
TRANS-4-(GUANIDINOMETHYL)-CYCLOHEXANE-L-YL-D-3-CYCLOHEXYLALANYL-L-AZETIDINE-2-YL-D-TYROSINYL-L-HOMOARGININAMIDEexperimentalunknowntargetDetails
2-[3-chloro-6-[2,2-difluoro-2-(1-oxidopyridin-1-ium-2-yl)ethyl]imino-1-hydroxypyridin-2-yl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamideexperimentalunknowntargetDetails
1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANEexperimentalunknowntargetDetails
1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANEexperimentalunknowntargetDetails
SuramininvestigationalunknowntargetinhibitorDetails
Thrombomodulin Alfaapproved, investigationalyestargetinhibitorDetails
FlovagatraninvestigationalunknowntargetDetails
Dabigatran etexilateapprovedyestargetinhibitorDetails
methyl L-phenylalaninateexperimentalyestargetinhibitorDetails
[(2R)-1-[(2S)-2-[[(2S,3S)-1-Chloro-6-(diaminomethylideneamino)-2-hydroxyhexan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]azaniumexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideexperimentalunknowntargetDetails
2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideexperimentalunknowntargetDetails
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineexperimentalunknowntargetDetails
N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideexperimentalunknowntargetDetails
N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDEexperimentalunknowntargetDetails
6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINEexperimentalyestargetinhibitorDetails
6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACIDexperimentalunknowntargetDetails
6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACIDexperimentalunknowntargetDetails
N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamideexperimentalunknowntargetDetails
1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDEexperimentalunknowntargetDetails
1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)-L-prolinamideexperimentalunknowntargetDetails
D-leucyl-N-(3-chlorobenzyl)-L-prolinamideexperimentalyestargetinhibitorDetails
D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamideexperimentalyestargetinhibitorDetails
1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamideexperimentalunknowntargetDetails
N-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-L-prolinamideexperimentalunknowntargetDetails
N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamideexperimentalunknowntargetDetails
1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)-L-prolinamideexperimentalunknowntargetDetails
D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamideexperimentalyestargetinhibitorDetails
D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamideexperimentalunknowntargetDetails
(3R)-8-(dioxidosulfanyl)-3-methyl-1,2,3,4-tetrahydroquinolineexperimentalunknowntargetDetails
D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamideexperimentalyestargetinhibitorDetails
beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamideexperimentalyestargetinhibitorDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
2-[2-(4-Chloro-Phenylsulfanyl)-Acetylamino]-3-(4-Guanidino-Phenyl)-PropionamideexperimentalunknowntargetDetails
3-Carbamimidamido-1,1-diphenylureaexperimentalunknowntargetDetails
N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINEexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamideexperimentalyestargetinhibitorDetails
D-phenylalanyl-N-benzyl-L-prolinamideexperimentalyestargetinhibitorDetails
N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDEexperimentalunknowntargetDetails
3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamideexperimentalunknowntargetDetails
CRA_8696experimentalyestargetinhibitorDetails
(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDEexperimentalunknowntargetDetails
2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDEexperimentalunknowntargetDetails
GW-813893experimentalunknowntargetDetails
N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDEexperimentalunknowntargetDetails
4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOLexperimentalyestargetinhibitorDetails
2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTERexperimentalunknowntargetDetails
5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)experimentalunknowntargetDetails
1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINEexperimentalunknowntargetDetails
Hemi-BabimexperimentalyestargetinhibitorDetails
4-TERT-BUTYLBENZENESULFONIC ACIDexperimentalyestargetinhibitorDetails
3-AMINO-3-BENZYL-9-CARBOXAMIDE[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONEexperimentalunknowntargetDetails
2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidineexperimentalunknowntargetDetails
4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINEexperimentalunknowntargetDetails
1-(2-{[(6-amino-2-methylpyridin-3-yl)methyl]amino}ethyl)-6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-olexperimentalunknowntargetDetails
(3Z,6S)-6-Chloro-1-(2-{[(5-chloro-1-benzothiophen-3-yl)methyl]amino}ethyl)-3-({2-[(2R)-2-piperidinyl]ethyl}imino)-2-piperazinolexperimentalunknowntargetDetails
N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]NAPHTHALENE-2-SULFONAMIDEexperimentalunknowntargetDetails
N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDEexperimentalunknowntargetDetails
2-(6-Chloro-3-{[2,2-difluoro-2-(2-pyridinyl)ethyl]amino}-2-oxo-1(2H)-pyrazinyl)-N-[(2-fluoro-6-pyridinyl)methyl]acetamideexperimentalunknowntargetDetails
2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDEexperimentalunknowntargetDetails
2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDEexperimentalunknowntargetDetails
3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTERexperimentalunknowntargetDetails
AC-(D)Phe-pro-borolys-OHexperimentalyestargetinhibitorDetails
AC-(D)PHE-PRO-BOROHOMOLYS-OHexperimentalyestargetinhibitorDetails
AC-(D)PHE-PRO-BOROHOMOORNITHINE-OHexperimentalyestargetinhibitorDetails
N-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamideexperimentalunknowntargetDetails
4-Hydroxyphenylpyruvic acidexperimentalyestargetinhibitorDetails
4-Iodobenzo[B]Thiophene-2-CarboxamidineexperimentalyestargetinhibitorDetails
4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINEexperimentalunknowntargetDetails
(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINEexperimentalunknowntargetDetails
4-({[4-(3-METHYLBENZOYL)PYRIDIN-2-YL]AMINO}METHYL)BENZENECARBOXIMIDAMIDEexperimentalunknowntargetDetails
1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANEexperimentalyestargetinhibitorDetails
[[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINEexperimentalunknowntargetDetails
N-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDEexperimentalunknowntargetDetails
N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamideexperimentalunknowntargetDetails
4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINEexperimentalyestargetinhibitorDetails
3-(4-CHLOROPHENYL)-5-(METHYLTHIO)-4H-1,2,4-TRIAZOLEexperimentalunknowntargetDetails
{(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetateexperimentalunknowntargetDetails
N-Methylphenylalanyl-N-[(trans-4-aminocyclohexyl)methyl]-L-prolinamideexperimentalunknowntargetDetails
Beta-(2-Naphthyl)-AlanineexperimentalyestargetinhibitorDetails
2-Naphthalenesulfonic acidexperimentalyestargetinhibitorDetails
[PHENYLALANINYL-PROLINYL]-[2-(PYRIDIN-4-YLAMINO)-ETHYL]-AMINEexperimentalunknowntargetDetails
4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDEexperimentalunknowntargetDetails
1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidineexperimentalunknowntargetDetails
Antihemophilic factor, human recombinantapproved, investigationalunknownenzymeactivatorDetails
Human C1-esterase inhibitorapprovedunknowntargetinhibitorDetails
Conestat alfaapproved, investigationalyestargetinhibitorDetails
Antithrombin Alfaapproved, investigationalyestargetinhibitorDetails
GabexateinvestigationalyestargetinhibitorDetails
NafamostatinvestigationalyestargetinhibitorDetails
Coagulation Factor IX HumanapprovedunknowntargetDetails
Anti-inhibitor coagulant complexapproved, investigationalyestargetagonistDetails
Copperapproved, investigationalunknowntargetDetails
Zincapproved, investigationalunknowntargetDetails
Turoctocog alfaapproved, investigationalyestargetbinderDetails
KappadioneapprovedunknowntargetagonistDetails
Lonoctocog alfaapproved, investigationalunknownenzymeactivatorDetails
Moroctocog alfaapprovedunknownenzymeactivatorDetails
Zinc acetateapproved, investigationalunknowntargetDetails
Turoctocog alfa pegolapprovedyestargetbinderDetails
EnoxaparinapprovedunknowntargetinhibitorDetails
2-(2-Hydroxy-Phenyl)-1h-Indole-5-CarboxamidineexperimentalyestargetinhibitorDetails
Atecegatran metoxilinvestigationalyestargetinhibitorDetails
AZD-8165investigationalyestargetinhibitorDetails
OdiparcilinvestigationalyestargetinhibitorDetails
EP-217609investigationalyestargetmodulatorDetails
SR-123781AinvestigationalyestargetmodulatorDetails
Y-27632experimentalyestargetinhibitorDetails
Dabigatranapproved, investigationalyestargetinhibitorDetails
Pyridoxal phosphateapproved, investigational, nutraceuticalyestargetinhibitorDetails
AnisindioneapprovedyestargetmodulatorDetails
MelagatranexperimentalyestargetinhibitorDetails