Prothrombin

BE0000048ProteinHumansF2

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. It is acted on by 149 drugs in DrugBank.

Gene name
F2
UniProtKB entry
P00734Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
622 residues · 70,036 Da
Also known as
3.4.21.5 · Coagulation factor II

Resolves to

Protein
UniProtP00734UniProt nameTHRB_HUMAN
Gene
HGNCHGNC:3535NCBI Gene2147GenBank339641GeneCardsF2
Pharmacology
IUPHAR/GtoPdb2362KEGGhsa:2147
Structure
PDB1A2CPDB1A3BPDB1A3E
Drugs

What you can answer from here — as of September 07, 2019

149DrugsApproved to experimental, with action, bond type and pharmacological action
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43Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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366+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prothrombin, how selective are they, and which programs against it are still in active trials?

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