- Accession Number
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Drug Drug Description Masoprocol Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Aminosalicylic acid An aminosalicylate drug used to induce remission in ulcerative colitis. Mesalazine An aminosalicylate drug used to treat mild to moderate active ulcerative colitis and also to maintain remission once achieved. Tolcapone A catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. Mexiletine A class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Methocarbamol A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. Entacapone A selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease. Monobenzone A hydroquinone derivative used to treat vitiligo. Bacitracin A cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections. Clofibrate A fibric acid derivative used to treat hypertriglyceridemia and high cholesterol. Hexachlorophene A chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser. Haloprogin Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor. Proparacaine A topical anesthetic used for ophthalmic practice. Propofol A medication used in general anesthesia and for sedation. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Guaifenesin An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses. Dienestrol A non steroidal estrogen used to treat atrophic vaginitis and kraurosis vulvae. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Balsalazide An aminosalicylate used to treat ulcerative colitis. Tolterodine A muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Olsalazine An anti-inflammatory agent used in the treatment of inflammatory bowel disease and ulcerative colitis. Bismuth subsalicylate An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Probucol Used to lower LDL and HDL cholesterol. P-Cresol Not Available 2-Aminophenol Not Available M-Cresol Not Available Hyperforin Hyperforin is a phytochemical generated by the plants of the Hypericum family. One of the most important members of this family, due to its medical properties, is Hypericum perforatum, also... 3-Chlorophenol Not Available 3,5-Dinitrocatechol Not Available 1,2-Dihydroxybenzene Not Available Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). P-Anisic Acid Not Available 2,4-Dihydroxybenzoic Acid Not Available IC261 Not Available 2-Chlorophenol Not Available Phenol An antiseptic and disinfectant used in a variety of settings. 4-Nitrocatechol Not Available 3-hydroxyanthranilic acid An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. Picric acid Used as antiseptic, astringent, and stimulant for epitheliazation. 3,4-Dihydroxybenzoic Acid Not Available Balanol Not Available 2-Nitro-4-cresol Not Available 4-Nitrophenyl Phosphate Not Available P-Nitrophenol Not Available 2,4-Dinitrophenol A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman,... 2-Amino-4-methylphenol Not Available Bithionol Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the... Phenolphthalein A drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures. Tesmilifene Intended for the treatment of various forms of cancer. Succinobucol Investigated for use/treatment in atherosclerosis, coronary artery disease, diabetes mellitus type 2, and in-stent restenosis. Tapinarof Investigated for use/treatment in psoriasis and psoriatic disorders. Vernakalant An antiarrhythmic medication used to treat patients with atrial fibrillation. Dersalazine Investigated for use/treatment in inflammatory bowel disease. BNC105 Investigated for use/treatment in cancer/tumors (unspecified). Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Fospropofol A sedative-hypnotic agent indicated for monitored anesthesia care (MAC) sedation in adult patients undergoing diagnostic or therapeutic procedures. Capsaicin A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. Phenyl aminosalicylate Not Annotated Triclosan An antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew. Triflusal A medication related to acetylsalicylic acid with antithrombotic effects used in the treatment of thromboembolic diseases. Ivacaftor A cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used alone or in combination products to treat cystic fibrosis in patients who have specific genetic mutations that are responsive to the medication. Etofibrate Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations. Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. Bisacodyl A stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults. Ciprofibrate Not Annotated Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Zucapsaicin A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. Efonidipine For the treatment of hypertension. Propoxycaine Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and... Mequinol A topical agent used in combination with tretinoin to treat solar lentigines. Hydroquinone A topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. Methyl salicylate A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons. Octisalate Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer. Homosalate As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer. Phenyl salicylate Pain and fever . Trolamine salicylate A medication used to relieve minor aches and pains of the muscles and joints. Resorcinol Contemporary therapeutic uses for resorcinol primarily revolve around the use of the phenol derivative as an active ingredient in topical antiseptics [L2745, L2744, L2727, F61] or as topical antibacterial skin... Cresol A dental disinfectant used to remove dental pulp. Hexylresorcinol An ingredient used to relieve irritation, pain, and prevent infection. Protocatechualdehyde Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde... Diethylamino hydroxybenzoyl hexyl benzoate Indicated for use as a sunscreen agent. Glycol salicylate A salicylate used to treat mild to moderate muscle pain. Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , . Guaiacol It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a... Dichlorophen Dichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from... Zeranol Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x... Curcumin No approved therapeutic indications. Raxatrigine Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. AUY922 AUY922 has been used in trials studying the treatment of Lymphoma, Breast Cancer, Metastatic Disease, Advanced Solid Tumors, and Hematologic Neoplasms, among others. Terameprocol Terameprocol has been investigated for the treatment of Brain and Central Nervous System Tumors. ABT-751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Lifibrol Lifibrol has been used in trials studying the basic science of Hyperlipoproteinemia and Hypercholesterolemia. Propyl Gallate Propyl Gallate is under investigation in clinical trial NCT01450098 (A Study of LY2484595 in Healthy Subjects). Emixustat Emixustat has been used in trials studying the treatment of Geographic Atrophy, Age-Related Macular Degeneration, and Dry Age-related Macular Degeneration. Salirasib Salirasib has been used in trials studying the diagnostic of Carcinoma, Non-Small-Cell Lung. Phloroglucinol A spasmolytic agent to treat colic, as well as spastic pain of the digestive and biliary tracts. Parachlorophenol An antibacterial agent used to prevent infections in root canals. Phenolsulfonphthalein Phenolsulfonphthalein or otherwise called phenol red is a pH indicator commonly used in cell biology laboratories. Phenolsulfonphthalein is being investigated for use clinically due to its weak estrogen mimicking actions... Sulfobromophthalein Sulfobromophthalein or otherwise called bromsulphthalein is used as a test of liver function in humans . Clofoctol An antibacterial agent indicated in the treatment of respiratory infections; or prevention of infections after ear, nose, and throat surgery. Hexobendine Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has... Wood creosote Not Annotated Bucetin Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication... Simfibrate Not Annotated Cyclofenil Not Annotated Policresulen Not Annotated Aloxiprin Not Annotated Clefamide Not Annotated Guacetisal Not Annotated 4-dimethylaminophenol Not Annotated Rimiterol Not Annotated Carbaspirin calcium An NSAID indicated in the treatment of short term pain and fever. Ethyl hydroxybenzoate Not Annotated Benorilate Not Annotated Bibrocathol Not Annotated Clofibride Not Annotated Anethole trithione A medication used to treat dry mouth associated with medication or radiotherapy of the head and neck. Nifuroxazide An antibiotic indicated in the treatment of susceptible gastrointestinal infections. Imidazole salicylate Not Annotated Hemoglobin crosfumaril Hemoglobin in which the alpha-subunit are cross-linked intramolecularly. Fenofibric acid A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. Amylmetacresol An antiseptic used to treat infections in the mouth and throat. Bismuth subgallate A medication used to deodorize flatulence and stools as well as hemostasis in soft tissue surgery. Diclofop-methyl Herbicide for control of wild oat & foxtails in cereal crops. Choline salicylate The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due... Thiosalicylic acid Not Annotated Butylparaben Not Annotated p-Aminophenol Not Annotated Benzylparaben Benzylparaben is used in allergenic testing. Propylparaben Propylparaben is used in allergenic testing. Potassium guaiacolsulfonate A mucolytic and expectorant indicated to relieve a productive cough. Methylparaben Methylparaben is used in allergenic testing. Deacetylbisacodyl Not Annotated Dienestrol diacetate Not Annotated Vanillic acid A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). KB-141 An anticholesteremic agent. Ampreloxetine Ampreloxetine is under investigation in clinical trial NCT03750552 (Clinical Effect of TD-9855 for Treating snOH in Subjects With Primary Autonomic Failure). Dihydrocapsiate Dihydrocapsiate is under investigation in clinical trial NCT00999297 (Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate). Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Carbidopa A dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms. Norepinephrine A sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. Dipivefrin A prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. Epinephrine A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. Orciprenaline A beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD. Dobutamine A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery. Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Dopamine A catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. Isoprenaline A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. Arbutamine Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in... Levodopa A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Fenoterol A beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma. 6-hydroxydopa quinone Not Available 2,5-di-tert-butylhydroquinone Not Available Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Droxidopa A medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Parkinson's disease. Etilevodopa Investigated for use/treatment in parkinson's disease. Levonordefrin A topical sympathomimetic amine found in local anesthetic products that is used for nasal decongestion or vasoconstriction during dental procedures. Protokylol Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States. Methyl vanillate Not Available Racepinephrine A bronchodilator used to treat intermittent asthma. HX-1171 Hx 1171 is under investigation in clinical trial NCT01548391 (A Phase I Clinical Study Study of the Safety, Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects). Dopexamine Dopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer. Dichloroisoproterenol Dichloroisoproterenol has been used in trials studying the treatment and basic science of Insulin Resistance and Polycystic Ovary Syndrome. Reproterol A short-acting β2 adrenoreceptor agonist used to treat various types of asthma including allergic asthma, non-allergic asthma, and exercise-induced asthma. Theodrenaline Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Melevodopa A methyl ester of levodopa indicated in combination with carbidopa for the treatment of Parkinson's disease. Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Adrenalone Not Annotated Fluorodopa (18F) Fluorodopa F 18 is indicated for use with positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adult patients with suspected Parkinsonian syndromes... Deoxyepinephrine Sympathomimetic, vasoconstrictor agent. J147 J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. [A31606,A31607,A31608] It is a curcumin derivative and a potent neurogenic... Phenylethyl resorcinol A tyrosinase inhibitor with skin-lightening activity. PF-05089771 PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee). Resorcinol monoacetate Not Annotated p-Hydroxymercuribenzoic acid Not Available Ethyl salicylate A salicylate indicated in the treatment of sports related pain. Zingerone Zingerone is a pungent component of ginger. Andarine Andarine is a non-steroidal selective androgen receptor modulator. Phloretin Phloretin is a natural dihydrochalcone found in apples and many other fruits. 4-Nitrocatechol sulfate Not Available 4-Vinylguaiacol Not Available 4-hydroxybenzoic acid Not Available t-Butylhydroquinone Not Available 1,3,5-Trimethoxybenzene A medication indicated for the symptomatic treatment of spastic pain of the urinary tract, renal colic, and painful disorders of the digestive and biliary tract. Anethole An excipient added to medications for flavouring. Dopastatin Dopastatin is under investigation in clinical trial NCT04335357 (TBR-760 in Adult Patients With Non-functioning Pituitary Adenomas). Hypothemycin Not Available
- Drugs & Drug Targets