This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Piroxicam cinnamate is an anti-inflammatory drug indicated to treat pain and inflammation.

Generic Name
Piroxicam cinnamate
DrugBank Accession Number
DB15883
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 461.49
Monoisotopic: 461.104541898
Chemical Formula
C24H19N3O5S
Synonyms
  • Cinnoxicam
  • Piroxicam cinnamate
  • Piroxicam cinnamic acid ester
External IDs
  • SPA-S-510
  • SPA-S-51O

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7E8Q32N75N
CAS number
87234-24-0
InChI Key
GPUVGQIASQNZET-CCEZHUSRSA-N
InChI
InChI=1S/C24H19N3O5S/c1-27-22(24(29)26-20-13-7-8-16-25-20)23(18-11-5-6-12-19(18)33(27,30)31)32-21(28)15-14-17-9-3-2-4-10-17/h2-16H,1H3,(H,25,26,29)/b15-14+
IUPAC Name
2-methyl-1,1-dioxo-3-[(pyridin-2-yl)carbamoyl]-2H-1lambda6,2-benzothiazin-4-yl (2E)-3-phenylprop-2-enoate
SMILES
CN1C(C(=O)NC2=CC=CC=N2)=C(OC(=O)\C=C\C2=CC=CC=C2)C2=C(C=CC=C2)S1(=O)=O

References

General References
  1. AIFA Product Information: SINARTROL (piroxicam cinnamate) tablet, suppository, and cream [Link]
ChemSpider
4940766
RxNav
33787
ChEBI
135749
ChEMBL
CHEMBL2106889
ZINC
ZINC000000608032

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamTopical1.5 %
SuppositoryRectal30 MG
TabletOral15 MG
TabletOral30 MG
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0022 mg/mLALOGPS
logP4.61ALOGPS
logP3.49ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)11.6ChemAxon
pKa (Strongest Basic)3.96ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area105.67 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity126.61 m3·mol-1ChemAxon
Polarizability46.25 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at September 24, 2020 20:35 / Updated at May 07, 2021 21:08