Piroxicam cinnamate
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Summary
Piroxicam cinnamate is an anti-inflammatory drug indicated to treat pain and inflammation.
- Generic Name
- Piroxicam cinnamate
- DrugBank Accession Number
- DB15883
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 461.49
Monoisotopic: 461.104541898 - Chemical Formula
- C24H19N3O5S
- Synonyms
- Cinnoxicam
- Piroxicam cinnamate
- Piroxicam cinnamic acid ester
- External IDs
- SPA-S-510
- SPA-S-51O
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Ankylosing spondylitis (as) •••••••••••• •••••• •••••••••••• •••••• Symptomatic treatment of Osteoarthritis (oa) •••••••••••• •••••• •••••••••••• •••••• Symptomatic treatment of Rheumatoid arthritis •••••••••••• •••••• •••••••••••• •••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7E8Q32N75N
- CAS number
- 87234-24-0
- InChI Key
- GPUVGQIASQNZET-CCEZHUSRSA-N
- InChI
- InChI=1S/C24H19N3O5S/c1-27-22(24(29)26-20-13-7-8-16-25-20)23(18-11-5-6-12-19(18)33(27,30)31)32-21(28)15-14-17-9-3-2-4-10-17/h2-16H,1H3,(H,25,26,29)/b15-14+
- IUPAC Name
- 2-methyl-1,1-dioxo-3-[(pyridin-2-yl)carbamoyl]-2H-1lambda6,2-benzothiazin-4-yl (2E)-3-phenylprop-2-enoate
- SMILES
- CN1C(C(=O)NC2=CC=CC=N2)=C(OC(=O)\C=C\C2=CC=CC=C2)C2=C(C=CC=C2)S1(=O)=O
References
- General References
- AIFA Product Information: SINARTROL (piroxicam cinnamate) tablet, suppository, and cream [Link]
- External Links
- ChemSpider
- 4940766
- 33787
- ChEBI
- 135749
- ChEMBL
- CHEMBL2106889
- ZINC
- ZINC000000608032
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Cream Topical 1.5 % Suppository Rectal 30 MG Tablet Oral 15 MG Tablet Oral 30 MG - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0022 mg/mL ALOGPS logP 4.61 ALOGPS logP 3.49 Chemaxon logS -5.3 ALOGPS pKa (Strongest Acidic) 11.6 Chemaxon pKa (Strongest Basic) 3.96 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 105.67 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 126.61 m3·mol-1 Chemaxon Polarizability 46.25 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0003900000-b254e9e6e5dfb269eddc Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-1504900000-9a8b6a960251989f41bf Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-03ka-3504900000-ac7118c54fa81b6c3d1b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0udi-3923600000-3c463d8b9b6cfa21e641 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-0092100000-122dc63f2c65992b9339 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-4965400000-a786380d06939b504176 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 214.1311191 predictedDarkChem Lite v0.1.0 [M+H]+ 214.6625191 predictedDarkChem Lite v0.1.0 [M+Na]+ 213.9341191 predictedDarkChem Lite v0.1.0
Drug created at September 24, 2020 20:35 / Updated at May 07, 2021 21:08