Acolbifene

DB16080InvestigationalSmall molecule

Acolbifene is under investigation in clinical trial NCT01452373 (Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women).

Mechanism: Pharmacologically active on Estrogen receptor
Curator reviewed
Formula / weight: C₂₉H₃₁NO₄ · 457.57 g/mol (avg)
Code names: SCH-57068

Resolves to

Compound

UNII815LJ9X0D1CAS182167-02-8ChEMBLCHEMBL68055

Structure

InChIKeyDUYNJNWVGIWJRI-LJAQVGFWSA-NSMILESCC1=C([C@@H](OC2=C1C=CC(O)=C2)C1=CC=C(OCCN2CCCCC2)C=C1)C1=CC=C(O)C=C1

Targets

P03372ESR1

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Acolbifene, and which of those have an active Phase 3 trial?

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