Lennox-Gastaut Syndrome (DBCOND0028949)

Identifiers

Synonyms
Lennox Gastaut Syndrome (LGS) / Lennox-Gastaut Syndrome (LGS) / Lennox Gastaut Syndrome / Lennox-Gastaut syndrome / Lennox-Gastaut syndrome (disorder) / Cutis verticis gyrata / Cutis verticis gyrata (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Cannabidiol
An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer.
Clobazam
A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
Clonazepam
A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
Fenfluramine
Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures.
Lamotrigine
A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
Rufinamide
An antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS).
Topiramate
An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04938427
A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut Syndrometreatment3completed
NCT05163314
A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrometreatment3recruiting
NCT05364021
Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathiestreatment1 / 2completed
NCT02224690
A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adultstreatment3completed
NCT05066217
EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Children With Lennox Gastaut Syndrometreatment2not_yet_recruiting
NCT03731715
Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut Syndromebasic_science1completed
NCT03467113
A Study to Assess the Safety and Tolerability of ZX008 in Children and Young Adults With Dravet Syndrome or Lennox Gastaut Syndrome Currently Taking Cannabidioltreatment1completed
NCT02910297
The Pharmacokinetics of Cannabidiol (CBD) and Its Effects in Children With Severe EpilepsyNo drug interventionsNot AvailableNot Availablewithdrawn
NCT02655198
Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut Epilepsytreatment2active_not_recruiting
NCT01146951
A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304)treatment3completed
NCT01405053
Study of Rufinamide in Pediatric Subjects 1 to Less Than 4 Years of Age With Lennox-Gastaut Syndrome Inadequately Controlled With Other Anti-epileptic Drugstreatment3completed
NCT02731300
Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot StudyNo drug interventionstreatment4completed
NCT01160770
Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut Syndrometreatment3completed
NCT02632149
Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut SyndromeNo drug interventionstreatment0unknown_status
NCT01991041
European Registry of Anti-Epileptic Drug Use in Patients With Lennox-Gastaut Syndrome (LGS)No drug interventionsNot AvailableNot Availablecompleted
NCT06464653
Forel's Field Electrical Stimulation for Lennox-Gastaut SyndromeNo drug interventionstreatmentNot Availablerecruiting
NCT06401538
BMB-101 in Absence Epilepsy and DEENo drug interventionstreatment2not_yet_recruiting
NCT05485831
Epidyolex® in Lennox Gastaut and Dravet Syndrome: an Observational Study in ITALYNot AvailableNot Availablenot_yet_recruiting
NCT03955432
Long-term Cardiac Monitoring in EpilepsyNo drug interventionstreatmentNot Availableterminated
NCT03936777
A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrometreatment3active_not_recruiting
NCT05339126
RNS System LGS Feasibility StudyNo drug interventionstreatment2recruiting
NCT03355209
A Study to Investigate the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) as an Adjunctive Therapy in Children and Adults With Lennox-Gastaut Syndrometreatment3completed
NCT02307578
An Extended Access Program (EAP) for PerampanelNot AvailableNot Availableavailable
NCT04062981
Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndromebasic_science1completed
NCT02175173
Post-marketing Surveillance of Long-term Administration of Inovelon Tablets in Patients With Lennox-Gastaut SyndromeNot AvailableNot Availablecompleted
NCT03254680
Turmeric as Treatment in EpilepsyNo drug interventionstreatmentNot Availablewithdrawn
NCT01151540
A Long Term Extension Study of E2080 in Lennox-Gastaut Patientstreatment3completed
NCT00552045
Epilepsy Phenome/Genome ProjectNo drug interventionsNot AvailableNot Availablecompleted
NCT02318537
Cannabidiol Oral Solution as an Adjunctive Therapy for Treatment of Participants With Inadequately Controlled Lennox-Gastaut Syndrometreatment3withdrawn
NCT03650452
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathiestreatment2completed
NCT06149663
Intermediate-Size Expanded Access Protocol (EAP) for LP352Not AvailableNot Availableavailable
NCT05374824
Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut SyndromeNo drug interventionsNot AvailableNot Availablerecruiting
NCT04611438
Research on Cognitive Effect of Cannabidiol on Dravet Syndrome and Lennox-Gastaut SyndromeGastaut Syndrometreatment3unknown_status
NCT03778424
An Extended Access Program (EAP) for Participants Who Have Completed Rufinamide Study E2080-G000-303Not AvailableNot Availableavailable
NCT05219617
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adultstreatment3recruiting
NCT02224560
Efficacy and Safety of GWP42003-P for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adultstreatment3completed
NCT05626634
Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathytreatment2active_not_recruiting
NCT01370486
Melatonin Versus Placebo in the Lennox-Gastaut Syndrome: Neurophysiological and Neuropsychological Effectstreatment4withdrawn
NCT02224573
An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut Syndromestreatment3completed
NCT00004776
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut Syndrometreatment3completed
NCT04133480
Investigation of Cognitive Outcomes With Cannabidiol Oral Solutiontreatment4withdrawn
NCT00004729
Ketogenic Diet for Child Epilepsy and Seizure ControlNo drug interventionstreatmentNot Availablecompleted
NCT02815540
The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe Epilepsydiagnostic1 / 2terminated
NCT06395792
A Study on Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS) in Children, Teenagers and Adults in PortugalNo drug interventionsNot AvailableNot Availablewithdrawn
NCT06422377
A Study Evaluating Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to Fenfluraminetreatment3terminated
NCT02834793
Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut Syndrometreatment3terminated
NCT03635073
A Study of Soticlestat in Adults and Children With Rare Epilepsiestreatment2active_not_recruiting
NCT05982717
A Study to Gather Information About Overall Occurrence and New Cases of Dravet and Lennox-Gastaut Syndromes in Children, Teenagers and Adults in SpainNo drug interventionsNot AvailableNot Availablerecruiting
NCT05044819
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solutiontreatment4active_not_recruiting