Locally Advanced Breast Cancer (LABC)

Also known as: Locally Advanced Breast Cancer / Locally Advance Breast Cancer (LABC) / Malignant neoplasm of breast / Malignant breast neoplasm / Breast cancer / Breast tumor malignant / Breast tumour malignant / Breast cancer NOS / Breast cancer stage unspecified / Ca breast

DrugDrug NameDrug Description
DB01217AnastrozoleA competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
DB01248DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
DB06205Hyaluronidase (human recombinant)An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
DB04845IxabepiloneA microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines.
DB06366PertuzumabAn antineoplastic agent used in the treatment of HER2-positive metastatic breast cancer in combination with other antineoplastic agents.
DB11760TalazoparibA poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer.
DB00072TrastuzumabA monoclonal anti-human epidermal growth factor receptor 2 protein antibody used to treat HER2-positive breast, gastroesophageal, and gastric cancers.
DrugDrug NameTargetType
DB01217AnastrozoleCytochrome P450 19A1target
DB01217AnastrozoleP-glycoprotein 1transporter
DB01217AnastrozoleCytochrome P450 3A4enzyme
DB01217AnastrozoleCytochrome P450 3A5enzyme
DB01217AnastrozoleCytochrome P450 2C8enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 1-4enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 1-3enzyme
DB01217AnastrozoleUDP-glucuronosyltransferase 2B7enzyme
DB01217AnastrozoleCytochrome P450 1A2enzyme
DB01217AnastrozoleCytochrome P450 2C9enzyme
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelP-glycoprotein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB06205Hyaluronidase (human recombinant)Hyaluronic acidtarget
DB06205Hyaluronidase (human recombinant)Transforming growth factor beta-1target
DB04845IxabepiloneTubulin beta-3 chaintarget
DB04845IxabepiloneCytochrome P450 3A4enzyme
DB04845IxabepiloneP-glycoprotein 1transporter
DB06366PertuzumabReceptor tyrosine-protein kinase erbB-2target
DB11760TalazoparibPoly [ADP-ribose] polymerase 1target
DB11760TalazoparibPoly [ADP-ribose] polymerase 2target
DB11760TalazoparibP-glycoprotein 1transporter
DB11760TalazoparibATP-binding cassette sub-family G member 2transporter
DB00072TrastuzumabReceptor tyrosine-protein kinase erbB-2target
DrugDrug NamePhaseStatusCount
DB12001Abemaciclib0Withdrawn1
DB11714Durvalumab0Withdrawn1
DB11062Octisalate0Withdrawn1
DB09535Octocrylene0Withdrawn1
DB09321Zinc oxide0Withdrawn1
DB09274Artesunate1Completed1
DB11945Avelumab1Recruiting1
DB01101Capecitabine1Completed1
DB12483Copanlisib1Terminated1
DB11651Dactolisib1Completed1
DB00947Fulvestrant1Recruiting1
DB01259Lapatinib1Completed1
DB09074Olaparib1Recruiting1
DB09073Palbociclib1Recruiting2
DB00072Trastuzumab1Completed1
DB05773Trastuzumab emtansine1Terminated1
DB09073Palbociclib1 / 2Recruiting1
DB12001Abemaciclib2Recruiting2
DB00112Bevacizumab2Completed1
DB00958Carboplatin2Suspended1
DB14707Cemiplimab2Recruiting1
DB00531Cyclophosphamide2Recruiting1
DB00531Cyclophosphamide2Suspended1
DB01248Docetaxel2Suspended1
DB15627Dostarlimab2Recruiting1
DB00997Doxorubicin2Recruiting1
DB00997Doxorubicin2Suspended1
DB11714Durvalumab2Recruiting1
DB00947Fulvestrant2Recruiting1
DB12047Ganetespib2Recruiting1
DB12205Ganitumab2Recruiting1
DB00441Gemcitabine2Completed1
DB01275Hydralazine2Terminated1
DB00762Irinotecan2Recruiting1
DB12437Irosustat2Completed1
DB15409Ladiratuzumab vedotin2Recruiting1
DB01006Letrozole2Recruiting1
DB00825Levomenthol2Recruiting1
DB00331Metformin2Recruiting1
DB11828Neratinib2Recruiting1
DB09074Olaparib2Recruiting1
DB01229Paclitaxel2Recruiting1
DB01229Paclitaxel2Suspended1
DB09073Palbociclib2Recruiting1
DB12090Patritumab2Recruiting1
DB00019Pegfilgrastim2Suspended1
DB09037Pembrolizumab2Recruiting1
DB06366Pertuzumab2Recruiting1
DB06366Pertuzumab2Suspended1
DB12978Pexidartinib2Recruiting1
DB11760Talazoparib2Recruiting1
DB15295Tenalisib2Not Yet Recruiting1
DB00072Trastuzumab2Recruiting1
DB00072Trastuzumab2Suspended1
DB16342Trastuzumab duocarmazine2Recruiting1
DB05773Trastuzumab emtansine2Recruiting1
DB12056Trebananib2Recruiting1
DB15442Trilaciclib2Recruiting1
DB11652Tucatinib2Recruiting1
DB07232Veliparib2Recruiting1
DB00399Zoledronic acid2Completed1
DB00990Exemestane3Completed1
DB00947Fulvestrant3Completed1
DB14993Pyrotinib3Not Yet Recruiting1
DB01248Docetaxel4Completed1
DB01006Letrozole4Completed1