Steatohepatitis, Nonalcoholic (DBCOND0119264)

Identifiers

Synonyms
Nonalcoholic Steatohepatitis / Non-Alcoholic Steatohepatitis / Nonalcoholic steatohepatitis (NASH) / NASH / Nonalcoholic steatohepatitis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Silibinin
A flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04971785
Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)treatment2active_not_recruiting
NCT05011305
Saroglitazar Magnesium for the Treatment of Nonalcoholic Steatohepatitis with Fibrosistreatment2active_not_recruiting
NCT05012423
FTIH Study of ECC0509 in Healthy VolunteersNo drug interventionstreatment1completed
NCT05809934
A Study to Evaluate AZD2693 in Participants Who Are Carriers of the PNPLA3 148M Risk Allele With Non-cirrhotic Non-alcoholic Steatohepatitis With FibrosisNo drug interventionstreatment2active_not_recruiting
NCT06465186
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)treatment2recruiting
NCT06594523
A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosistreatment3not_yet_recruiting
NCT05083390
Norursodeoxycholic Acid vs. Placebo in NASHtreatment2recruiting
NCT01205087
Safety and Efficacy of Oral Administration of Anti-CD3 Monoclonal Antibody (mAb)in Patients With the Metabolic Syndrometreatment2completed
NCT02442687
JKB-121 for the Treatment of Nonalcoholic SteatohepatitisNo drug interventionstreatment2completed
NCT02933554
Bariatric Embolization of Arteries for the Treatment of Nonalcoholic SteatohepatitisNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03439254
Study Evaluating the Efficacy and Safety of Obeticholic Acid in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitistreatment3completed
NCT04828551
Noninvasive Biomarkers of Metabolic Liver Disease 1.1No drug interventionsdiagnosticNot Availablecompleted
NCT05877547
A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)treatment2active_not_recruiting
NCT01002547
Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Hispanics With Diabetes Mellitus Type 2 (T2DM) and Role of Treatmenttreatment4completed
NCT04210245
Study of Aldafermin (NGM282) in Subjects With Compensated Cirrhosis (ALPINE 4)treatment2completed
NCT01399645
Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetestreatment2completed
NCT03151798
The Liver Health Study for Patients With NAFLDNo drug interventionsotherNot Availablecompleted
NCT00842205
Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infectionbasic_scienceNot Availableunknown_status
NCT03282305
Great China Fatter Liver Consortium (GC_FLC) Study to Assess the Progress of NAFLD/NASH in ChineseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01679197
Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophytreatment2completed
NCT05733897
Using Hydroxychloroquine to Treat Nonalcoholic SteatohepatitisNot AvailableNot Availablerecruiting
NCT00590161
Pentoxifylline in Patients With Nonalcoholic Steatohepatitistreatment2completed
NCT01828528
Impact of Bariatric Surgery on Nonalcoholic Fatty Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05983328
Phase I Pharmacokinetic Study of HUYPS-1 in Healthy VolunteersNo drug interventionstreatment1completed
NCT00586911
Betaine in Patients With Nonalcoholic Steatohepatitistreatment2completed
NCT00152711
Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic SteatohepatitisNo drug interventionstreatmentNot Availableunknown_status
NCT04216693
Digoxin for Patients With Non-alcoholic Steatohepatitis (NASH)treatment2withdrawn
NCT04389593
Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology as ReferenceNo drug interventionsNot AvailableNot Availablerecruiting
NCT02148471
Fatty Acids, Genes and Microbiota in Fatty LiverNo drug interventionsNot AvailableNot Availablecompleted
NCT05430178
Metabolic Pathology of Pediatric NAFLDNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05560607
Knockdown of HSD17B13 mRNA, Pharmacokinetics, Safety, and Tolerability, of AZD7503 in Non-Alcoholic Fatty Liver DiseaseNo drug interventionsother1completed
NCT05824156
CM-101 in NASH Patients - The SPLASH Studytreatment2completed
NCT02633956
Combination Obeticholic Acid (OCA) and Statins for Monitoring of Lipids (CONTROL)treatment2completed
NCT02210715
Raltegravir-based Antiretroviral Versus Maintaining Any Other Antiretroviral Therapy in HIV Mono-infected Patientsscreening4completed
NCT02717000
NASH: Non-invasive Diagnostic Markers and ImagingNo drug interventionsNot AvailableNot Availableunknown_status
NCT02217475
Efficacy and Safety Study of Cenicriviroc for the Treatment of Nonalcoholic Steatohepatitis (NASH) in Adult Participants With Liver Fibrosistreatment2completed
NCT01355575
Rifaximin in Fatty Liver Diseasetreatment4terminated
NCT05309642
Nonalcoholic Fatty Liver Disease - Intermittent Calorie Restriction (FLICR) StudyNo drug interventionstreatmentNot Availablecompleted
NCT04012242
Innovative Liver Elasticity, Attenuation, and Dispersion Ultrasound StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02510599
Safety and Efficacy of Solithromycin in the Treatment of Nonalcoholic Steatohepatitis Without Cirrhosistreatment2completed
NCT05165706
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin ResistanceNo drug interventionspreventionNot Availablerecruiting
NCT04501406
Low-Dose Pioglitazone in Patients With NASH (AIM 2)treatment2recruiting
NCT04801849
Vitamin E Dosing Studytreatment2recruiting
NCT00509418
Efficacy and Safety of Viusid in Patients With Nonalcoholic SteatohepatitisNo drug interventionstreatment3completed
NCT03861819
Feasibility of VIIT in Adults With NASHNo drug interventionsotherNot Availablecompleted
NCT01237119
Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitistreatment2completed
NCT02792634
Pathogenesis of Non-alcoholic Steatohepatitis and Liver Regeneration After Bariatric SurgeryNo drug interventionsNot AvailableNot Availableunknown_status
NCT04710524
FM101 Efficacy Study in Adults With Nonalcoholic Fatty Liver Disease or Nonalcoholic SteatohepatitisNo drug interventionstreatment2unknown_status
NCT05731596
Comparative Clinical Study to Evaluate the Efficacy and Safety of Rosuvastatin Vs CoQ10 on Nonalcoholic Steatohepatitistreatment3not_yet_recruiting
NCT03053063
Safety and Efficacy of Selonsertib in Adults With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)treatment3terminated
NCT02077374
A Study of IDN-6556 in Subjects With NAFLD and Raised Transaminasestreatment2completed
NCT03987074
Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH)treatment2completed
NCT00994682
University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)treatment4completed
NCT03248882
Phase 2a, Dose-ranging Study With PF-05221304 in Nonalcoholic Fatty Liver Disease (NAFLD)treatment2completed
NCT03970031
A Study of MSDC-0602K to Assess Glycemic Control and Cardiovascular Outcomes in Patients With Pre-T2D or T2D and NAFLD/NASHNo drug interventionstreatment3unknown_status
NCT04166773
A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH)treatment2completed
NCT03674476
An Investigational Study to Evaluate Experimental Medication BMS-986036 in Participants With Different Levels of Kidney Functiontreatment1completed
NCT02421094
Clinical Trial to Evaluate Efficacy of GR-MD-02 for Treatment of Liver Fibrosis in Patients With NASH With Advanced Fibrosistreatment2completed
NCT01466894
Safety and Efficacy Study of IMM 124-E (Bovine Colostrum) for Patients With Nonalcoholic Steatohepatitistreatment2withdrawn
NCT01919294
Testosterone Replacement in Non-alcoholic Steatohepatitis (TEREPINS)treatment2completed
NCT06365580
Dose Escalation Study of Kylo-0603 in Healthy SubjectsNo drug interventionstreatment1recruiting
NCT05343780
Clinical Trial to Investigate the Anti-oxidant Activity of Heptex in Patients With Apparent Risk Factors of NASHNo drug interventionssupportive_care2completed
NCT05526144
Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veteranstreatment2recruiting
NCT03656744
A Study of HTD1801 in Adults With Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM)No drug interventionstreatment2completed
NCT02307344
Effect of Nigella Sativa on Nonalcoholic Steatohepatitis and SteatosisNo drug interventionstreatmentNot Availableunknown_status
NCT02412540
Controlled Trial of WLS vs. CLI for Severely Obese Adolescents With NASHNo drug interventionstreatmentNot Availablecompleted
NCT03332940
An Evaluation of the Safety of Intravenous Tc 99m Tilmanocept and a Comparison of Imaging With Sulfur Colloid in Subjects With and Without NASHdiagnostic1completed
NCT03028740
AURORA: A Study for the Efficacy and Safety of Cenicriviroc (CVC) for the Treatment of Liver Fibrosis in Adults With Nonalcoholic Steatohepatitis (NASH)treatment3terminated
NCT00856869
Clearance of NRL972 in Patients With Cirrhosis, Nonalcoholic Steatohepatitis (NASH) and in Healthy Volunteersdiagnostic1 / 2completed
NCT03449446
Study to Evaluate the Safety and Efficacy of Selonsertib, Firsocostat, Cilofexor, and Combinations in Participants With Bridging Fibrosis or Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)treatment2completed
NCT01260246
Sitagliptin for the Treatment of Non-alcoholic Steatohepatitis in Patients With Type 2 DiabetestreatmentNot Availableterminated
NCT03163810
A Study to See if Low Level Laser Light Therapy (LLLT) Can Improve the Condition of Nonalcoholic Steatohepatitis (NASH)No drug interventionstreatmentNot Availablewithdrawn
NCT00740610
Safety, Tolerability, Pharmacokinetics and Activity of GS-9450 in Adults With Non-Alcoholic Steatohepatitis (NASH)treatment2completed
NCT04147195
Study of Various Treatments in Non-alcoholic Fatty Liver Disease (NAFLD) Patients Who Have Aspects of Non-alcoholic Steatohepatitis (NASH)treatment2terminated
NCT05792423
Conditionally Increased Output (CIO) Enhanced Ultrasound SystemNo drug interventionsotherNot Availablecompleted
NCT05330923
Effect of NNRTI or INSTI on Nonalcoholic Steatosis in HIV/AIDS PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04887038
First-in-Human Study of SRT-015 in Healthy Subjects.No drug interventionstreatment1completed
NCT04399538
Study of Pharmacodynamics and Safety of DGAT2i and ACCi Coadministered in Participants With Sponsor-defined Presumed Non Alcoholic Steatohepatitisbasic_science2completed
NCT01066364
Colesevelam Versus Placebo in the Treatment of Nonalcoholic Steatohepatitistreatment2completed
NCT03061721
Saroglitazar Magnesium in Patients With Nonalcoholic Fatty Liver Disease and/or Nonalcoholic Steatohepatitistreatment2completed
NCT05655221
A Trial to Evaluate the Safety Tolerability and Pharmacokinetics of B1344 by Subcutaneous Injection in Healthy SubjectsNo drug interventionstreatment1recruiting
NCT05979779
Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic SteatohepatitisNo drug interventionstreatment2active_not_recruiting
NCT05680233
Safety Study of OA-235i in Subjects With Nonalcoholic SteatohepatitisNo drug interventionstreatment1recruiting
NCT00820651
Efficacy and Safety of Diamel in Patients With Nonalcoholic SteatohepatitisNo drug interventionstreatment3completed
NCT02654977
CLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Metreleptin in Various Forms of Partial Lipodystrophytreatment2completed
NCT06342947
ALG-055009 in Non-cirrhotic Adults With MASH (HERALD)No drug interventionstreatment2active_not_recruiting
NCT02764047
Probiotics in the Treatment of NAFLDNo drug interventionstreatmentNot Availableunknown_status
NCT00013598
Treatment of Nonalcoholic Steatohepatitis With Pioglitazonetreatment2completed
NCT04235205
Efficacy and Safety of Elobixibat in Combination With Cholestyramine for Nonalcoholic Fatty Liver Diseasetreatment2completed
NCT05029583
Clinical Outcomes From Enhanced SCREENing Strategies for NASH in Type 2 Diabetes (SCREEN NASH T2D)No drug interventionsdiagnosticNot Availablerecruiting
NCT04342793
A Study to Evaluate the Efficacy and Safety of ALS-L1023 in Subjects With NASHNo drug interventionstreatment2completed
NCT03068078
A Reduced-carbohydrate Diet High in Monounsaturated Fats in Type 2 DiabetesNo drug interventionstreatmentNot Availablecompleted
NCT03329885
A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Participants and Patients With Average to Very Serious Psoriasistreatment1 / 2terminated
NCT00586885
Effects of Alanine in Patients With Nonalcoholic SteatohepatitistreatmentNot Availablecompleted
NCT03723252
Dapagliflozin Efficacy and Action in NASHtreatment3completed
NCT04389775
To Evaluate the Safety, Tolerability, PK, and PD of XW003 Injection in Healthy Adult ParticipantsNo drug interventionstreatment1completed
NCT00267670
Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASHtreatment2 / 3completed
NCT03486899
A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosistreatment2completed
NCT00583999
The Role of Leptin Receptors in NASHNo drug interventionsNot AvailableNot Availablecompleted
NCT00699036
Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH)treatment2unknown_status
NCT00586313
Endoscopic Ultrasound(EUS)-Guided TRUCUT Biopsy (EUS-TCB) of Suspected Nonalcoholic Fatty Liver Disease(NAFLD.)No drug interventionsdiagnosticNot Availablecompleted
NCT01016418
Bovine Colostrum for Patients With Non Alcoholic Fatty Liver DiseaseNo drug interventionstreatment1 / 2completed
NCT01051219
Anti-Fibrotic Effects of Losartan In Nash Evaluation Studytreatment3completed
NCT04565717
A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH)No drug interventionstreatment1terminated
NCT00794716
Pharmacokinetics of NRL972 in Patients With Nonalcoholic Steatohepatitis (NASH) and Non-Alcoholic Fatty Liver Disease (NAFLD)diagnostic2completed
NCT01094158
Study of Aramchol in Patients With Fatty Liver Disease or Nonalcoholic Steatohepatitistreatment2completed
NCT05720663
Predicting Outcomes in Nonalcoholic Steatohepatitis With Advanced FibrosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT02574325
A Study to Assess ARI-3037MO on Hepatic Fat Metabolism in Patients With Dysglycemia and Evidence of Hepatic SteatosisNo drug interventionstreatment2unknown_status
NCT04595474
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 DiabetesNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03725631
Non-invasive Evaluation of Liver Fibrosis, Steatosis, and NASH in NAFLDNo drug interventionsdiagnosticNot Availableunknown_status
NCT03676231
Study of SGM-1019 in Patients With Nonalcoholic Steatohepatitis (NASH)No drug interventionstreatment2terminated
NCT04152473
Safety and Tolerability of Oral Proglumide for NASHother1completed
NCT03602573
Liver Fibrosis in Peri-menopausal WomenNo drug interventionsNot AvailableNot Availableunknown_status
NCT02769091
A Study in Adult Patients With Nonalcoholic Steatohepatitis Who Also Have Type 2 DiabetesNo drug interventionstreatment2withdrawn
NCT02815891
A Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD)No drug interventionsNot AvailableNot Availablerecruiting
NCT04031729
Aspirin for the Treatment of Nonalcoholic Fatty Liver Diseasetreatment1 / 2completed
NCT03683589
De Novo Lipogenesis in Severity of NAFLDNo drug interventionsNot AvailableNot Availablecompleted
NCT00878592
Effect of Dietary and Life Style Modification on Post Liver Transplant ObesityNo drug interventionstreatmentNot Availableterminated
NCT04944992
A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001)treatment2completed
NCT02083367
Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy OutcomeNo drug interventionsNot AvailableNot Availablecompleted
NCT05084404
Efficacy and Safety of Guanabenz for Nonalcoholic Fatty Liver Diseasetreatment2unknown_status
NCT03059446
Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitistreatment2terminated
NCT03486912
A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosistreatment2completed
NCT00227110
Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH)treatment4completed
NCT04550481
Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Studyprevention2recruiting
NCT04462081
Non Alcoholic Fatty Liver Disease and Coronary Heart Disease in Type 2 Diabetes PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04137055
Study in Chinese Healthy Adults to Evaluate the Safety, Tolerability and Pharmacokinetics on ZSP0678, and the Effect of Food on ZSP0678 PharmacokineticsNo drug interventionstreatment1completed
NCT03053050
Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosistreatment3terminated
NCT04583423
A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001)No drug interventionstreatment2terminated
NCT03445208
A Study of Experimental Medication BMS-986036 Given to Healthy Participantstreatment1completed
NCT03375008
Predictable MR Index for Nonalcoholic Steatohepatitis (NASH)No drug interventionspreventionNot Availablecompleted
NCT03915002
Integrated Approaches for Identifying Molecular Targets in Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04707651
Formula Diet Treatment for NASH Patients.No drug interventionstreatmentNot Availableactive_not_recruiting
NCT04785937
Accuracy of Imaging Techniques in Diagnosing Steatohepatitis and Fibrosis in NAFLD PatientsNo drug interventionsdiagnosticNot Availableunknown_status
NCT06499675
Prevalence of Steatosis and Steatohepatitis in Patients Undergoing Bariatric Surgery; a Biopsy-based StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05946330
Nutritional Intervention IN Nash NON-ALCOHOLIC (NAFLD).No drug interventionstreatmentNot Availableactive_not_recruiting
NCT06537466
Ketogenic Diet in MASLD-related cACLDNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04080947
The Leukotriene Receptor Antagonist Montelukast in the Treatment of Non-alcoholic Steatohepatitistreatment1 / 2completed
NCT06400771
Safety of DNP007 in Healthy SubjectsNo drug interventionshealth_services_research1recruiting
NCT04284371
The Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) Pediatric PatientsNo drug interventionsNot AvailableNot Availableterminated
NCT06302049
Clinical Study Evaluating the Safety and Efficacy of Esomeprazole in Treatment of Non-alcoholic Steatohepatitistreatment1 / 2recruiting
NCT04175392
Effect of Probiotics in Non-alcoholic Fatty Liver Disease and Steatohepatitistreatment1 / 2terminated
NCT04861012
Screening for Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD) at Al-Rajhy Hospital Nutrition Clinic. Assiut, EgyptNo drug interventionsscreeningNot Availableunknown_status
NCT04932512
A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Multiple Doses of ION224No drug interventionstreatment2completed
NCT04822181
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)treatment3active_not_recruiting
NCT05016882
Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH)treatment2active_not_recruiting
NCT05254626
Efficacy and Safety of Dapagliflozin in Patients with Non-alcoholic Steatohepatitistreatment2completed
NCT05462353
Study to Evaluate the Safety, Tolerability, and Efficacy of ASC41 Tablets in Adult Patients With NASHNo drug interventionstreatment2recruiting
NCT06054815
Study to Evaluate the Efficacy and Safety of DA-1241 in Subjects with Presumed NASHtreatment2active_not_recruiting
NCT06105060
Clinical Effects of New Approach on Patients with Non-alcoholic Steatohepatitistreatment0completed
NCT05517564
First-in-Human Study of GM-60106 in Healthy Adults and Otherwise Healthy Adults With an Increased Body Mass Index and Markers of Non-Alcoholic Fatty Liver DiseaseNo drug interventionstreatment1unknown_status
NCT02721264
Fecal Microbiota Therapy Versus Standard Therapy in NASH Related Cirrhosis.treatmentNot Availableunknown_status
NCT04666402
Integrated Diagnostics for Early Diagnosis of Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT05397379
A Safety, Tolerability, Efficacy, and Pharmacokinetics Study of HEC96719 in Subjects With Non-Cirrhotic Non-Alcoholic SteatohepatitisNo drug interventionstreatment2completed
NCT01696487
Impact of Fructose Consumption on Intestinal Permeability in Non-alcoholic Fatty Liver Disease (NAFLD) - a Pilot Study.No drug interventionspreventionNot Availablecompleted
NCT02235233
Effect of Non-Alcoholic Steatohepatitis (NASH) on the Pharmacokinetics of 99mTechnetium-Mebrofeninbasic_science1completed
NCT04302051
Assessment of Fatty Liver With Thermo-acoustic DeviceNo drug interventionsNot AvailableNot Availablerecruiting
NCT04722653
A Research Study Looking at How the Medicine NNC0194-0499 Behaves in Japanese and Non-Asian MenNo drug interventionstreatment1completed
NCT03377153
The Effects of Hesperidin and Flaxseed on Biochemical Factors and Hepatic Fibrosis in Nonalcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT03432377
Coffee Consumption and NASH in the French Population.No drug interventionsNot AvailableNot Availablecompleted
NCT04872777
Mobile Health Delivered Lifestyle Intervention Program in Patients With NASHNo drug interventionstreatmentNot Availablecompleted
NCT04931147
A 3-part Study to Evaluate Safety, Tolerability, Food Effect and Drug-drug Interactions of RXC007 in Healthy VolunteersNo drug interventionstreatment1completed
NCT05217745
MLCT Oil for Fatty Liver - PASS TrialNo drug interventionstreatmentNot Availableunknown_status
NCT02541045
Clinical Trial to Evaluate the Efficacy of Metadoxine as a Therapy for Patients With Non-alcoholic Steatohepatitistreatment3withdrawn
NCT04198805
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)treatment2completed
NCT02528305
The Effect of HIT in Patients With Non-alcoholic Fatty Liver Disease/SteatohepatitisNo drug interventionstreatmentNot Availablecompleted
NCT00677183
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in ChildrenNo drug interventionsNot AvailableNot Availablewithdrawn
NCT06308861
Phase 1 Study to Investigate Safety, Tolerability, PK/PK of J2H-1702 in Healthy MalesNo drug interventionstreatment1completed
NCT03674528
Technical Validation of MR Biomarkers of Obesity-Associated NAFLDNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05065593
The Effect of Aerobic and Resistant Exercise Training in Patients With Non-Alcoholic SteatohepatitisNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT01384578
Pentoxiphylline and Vitamin E Versus Vitamin E in Patients With Non- Alcoholic Steatohepatitistreatment3withdrawn
NCT03513588
2-Week Study In People With Nonalcoholic Fatty Liver DiseaseNo drug interventionsbasic_science1completed
NCT00680407
Phase II Trial of Silymarin for Non-Cirrhotic Patients With Non-Alcoholic Steatohepatitistreatment2completed
NCT03883607
Elafibranor, PK and Safety in Children and Adolescents 8 to 17 Years of Age With Non Alcoholic Steatohepatitis (NASH)treatment2terminated
NCT02395900
The Effects of Flaxseed Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver DiseaseNo drug interventionstreatment2 / 3completed
NCT00492700
A One-Year, Randomized, Double-Blind, Placebo-Controlled Trial of Rosiglitazone in Non-Alcoholic Steatohepatitistreatment2completed
NCT01791959
The Effects of Synbiotics Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic SteatohepatitisNo drug interventionstreatment2 / 3completed
NCT00668070
A Proof-of-principle Study of Oral Treatment of Non-alcoholic Steatohepatitis With a Novel PDE4 Inhibitor ASP9831No drug interventionstreatment2completed
NCT04501042
Investigation on the Role of Gut-liver Axis for Non-alcoholic Steatohepatitis Through Bariatric SurgeryNo drug interventionsNot AvailableNot Availableunknown_status
NCT04042142
Glucagon Resistance in Patients With NAFLDNo drug interventionsbasic_scienceNot Availablecompleted
NCT02970942
Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis.treatment2completed
NCT05668936
A Thorough QTC Study to Assess the Effect of Cotadutide on Cardiac Repolarization in Healthy Participantstreatment1terminated
NCT01766713
Ezetimibe Versus Placebo in the Treatment of Non-alcoholic Steatohepatitistreatment2completed
NCT03969719
A Double-blind Study to Assess 2 Doses of an Investigational Product for 16 Weeks in Participants With Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitusbasic_science2completed
NCT06569524
Efficacy and Safety of Recombinant Human FGF21-Fc Fusion Protein for Injection (TQA2225/AP025) in Adult Subjects With Non-alcoholic Steatohepatitis (NASH)No drug interventionstreatment2recruiting
NCT04142424
A Study to Understand the Safety, Tolerability, and Activity of Drug in Body Over a Period of Time of AZD2693, in Subjects of Non-Childbearing Potential in Overweight But Otherwise Healthy Subjects, and Healthy Chinese and Japanese SubjectsNo drug interventionstreatment1completed
NCT04783116
Plant Stanols and Liver Inflammation in Overweight and Obese ChildrenNo drug interventionstreatmentNot Availableunknown_status
NCT04422496
The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC96719 Tablets in Healthy SubjectsNo drug interventionstreatment1completed
NCT05294458
A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy Subjectstreatment1completed
NCT06519448
Reducing Non-Alcoholic SteatohepatitistreatmentNot Availableenrolling_by_invitation
NCT04571957
Expanding Donor Pool for Live Donor Liver Transplantation: Utilization of Donors With NASH After OptimizationNo drug interventionsNot AvailableNot Availablecompleted
NCT06052566
A Study of Efinopegdutide in Participants With Hepatic Impairment (MK-6024-014)treatment1recruiting
NCT05053165
A Study to Assess the Safety and Tolerability of LB-P6 and LB-P8 in Healthy Participantstreatment1completed
NCT05751720
Effect on Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus With Gastric Inhibitory Polypeptide/Glucagon Like Peptide-1 AnalogueNo drug interventionstreatment1 / 2recruiting
NCT03839082
Structured Mobile Technology Based Lifestyle Program vs Usual Care for Patients With Non-alcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT05301231
Omics-based Predictors of NAFLD/Potential NASHNo drug interventionsNot AvailableNot Availableunknown_status
NCT03421431
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Non-Alcoholic SteatohepatitisNo drug interventionstreatment2completed
NCT04800094
Pediatric Liver Fat Quantification (LFQ) Phase 2 Pilot StudyNo drug interventionsdiagnosticNot Availablecompleted
NCT02686762
Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosistreatment2completed
NCT02571192
A Study to Investigate How the Study Drug SHP626 is Eliminated From the Body After One Dosebasic_science1completed
NCT03377140
The Effects of Hesperidin on Biochemical Factors and Hepatic Fibrosis in Nonalcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT03142867
The Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) in AdultsNo drug interventionsNot AvailableNot Availableterminated
NCT02413372
A Study of BMS-986036 in Subjects With Non-Alcoholic Steatohepatitis (NASH)treatment2completed
NCT04690972
"Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01617772
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitistreatment2unknown_status
NCT03198572
Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitistreatment4recruiting
NCT03743272
Repeatability and Reproducibility of Multiparametric MRINo drug interventionsNot AvailableNot Availableunknown_status
NCT03656068
An Evaluation of the Safety and Efficacy of Nitazoxanide on Collagen Turnover in NASH Patients With Fibrosisbasic_science2completed
NCT01629095
Genetic Studies of Non-Alcoholic Fatty Liver DiseaseNo drug interventionsNot AvailableNot Availableterminated
NCT04365855
The Olmsted NAFLD Epidemiology Study (TONES)No drug interventionsdiagnosticNot Availablerecruiting
NCT04829123
The Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of HEC88473 in Healthy SubjectsNo drug interventionstreatment1completed
NCT00681408
Omega 3 Fish Oil Supplements vs. Placebo for Patients With Non-alcoholic Steatohepatitis (NASH)treatment2 / 3completed
NCT02530138
The Effect of Synbiotics Supplement on Lipid Profile, Liver Enzymes, Inflammatory Factors and Hepatic Fibrosis in Lean and Normal Weight Patients With Nonalcoholic Fatty LiverNo drug interventionstreatment2 / 3unknown_status
NCT04573543
The Role of Immune Semaphorins in NAFLDNo drug interventionsNot AvailableNot Availablecompleted
NCT02075164
Unravelling Mechanisms of Fructose vs Glucose Consumption in the Pathogenesis and Progression of NAFLDNo drug interventionspreventionNot Availableunknown_status
NCT06138821
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled TrialNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06176079
Hyperpolarized Pyruvate (13C) Magnetic Resonance Imaging In Patients With Fatty Liver DiseaseNot AvailableNot Availablerecruiting
NCT02287779
Safety and Tolerability Study of SHP626 in Overweight and Obese Adultstreatment1completed
NCT00678587
Eltrombopag To Reduce The Need For Platelet Transfusion In Subjects With Chronic Liver Disease And Thrombocytopenia Undergoing Elective Invasive Procedurestreatment3terminated
NCT02231333
The Efficacy of S-adenosyl Methionine (SAMe) Versus Pentoxiphylline in Patients With Non-alcoholic Steatohepatitis With FibrosistreatmentNot Availablecompleted
NCT01056133
Effect of Fish-oil on Non-alcoholic Steatohepatitis (NASH)No drug interventionstreatment2completed
NCT04202354
Study of ARO-HSD in Healthy Volunteers and Patients With Non-Alcoholic Steatohepatitis (NASH) or Suspected NASHNo drug interventionstreatment1completed
NCT03987451
A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damagetreatment2completed
NCT06552377
Ultrasound and Attenuation ImagingNo drug interventionsNot AvailableNot Availablecompleted
NCT05942547
the Efficacy and Safety of Diosmin on Non-diabetic Patients With Non-alcoholic Steatohepatitis.treatment3recruiting
NCT04190498
Sleep Apnoea Syndrome and Hepatocellular CarcinomaNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03950505
To Evaluate the Effect of Nesinaact on Non-alcoholic Steatohepatitis Through MRI and Liver Fibroscan in Patients With Type 2 Diabetestreatment4unknown_status
NCT05728697
Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT01695083
Non Invasive Measurements of Fibrosis, Inflammation and Steatohepatitis in Morbidly Obese PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT06160271
Study of Liver Fibrosis Stage Assessment by Fibroblast Activation Protein Imaging in Patients With Biopsy for Suspected or Proven Nonalcoholic SteatohepatitisNo drug interventionsdiagnostic2not_yet_recruiting
NCT05766709
A Research Study Comparing Blood Levels of Medicines NNC0194-0499 and Semaglutide Administered as a Combination Formulation Versus Two Separate Formulationstreatment1completed
NCT01278056
The Impact of Deferasirox on Non-Alcoholic-Steatohepatitistreatment1 / 2completed
NCT05945537
A Study of INI-822 in Healthy Volunteers and Participants With Non-alcoholic Steatohepatitis (NASH) or Presumed NASHNo drug interventionstreatment1recruiting
NCT05357352
Effect of Patient Demographics, Comorbidities, and Medications on Severity of NASH FibrosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03884075
Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)basic_science2recruiting
NCT01761370
Intragastric Balloon for Treatment of Non Alcoholic Steatohepatitis (NASH)No drug interventionstreatmentNot Availablecompleted
NCT03535142
Prognostic Significance of Fatty Liver Disease in Bariatric PatientsNo drug interventionsdiagnosticNot Availablerecruiting
NCT04190849
European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD)No drug interventionsNot AvailableNot Availablerecruiting
NCT05574036
Comparative Study Between Febuxostat Versus Vitamin E in Non-alcoholic Steatohepatitis Patients With Hyperuricemiatreatment2recruiting
NCT01279434
Vitamin E Versus Vitamin E Plus Pentoxiphyllin in Patients With Nonalcoholic Steatohepatitis: A Prospective Randomized Clinical TrialtreatmentNot Availablewithdrawn
NCT06297434
Phase 2a Study to Evaluate Safety and Explore Efficacy of J2H-1702 for NASHNo drug interventionstreatment2recruiting
NCT02279524
A Clinical Trial to Evaluate the Efficacy and Safety of Two Aramchol Doses Versus Placebo in Patients With NASHtreatment2completed
NCT05480696
Soluble Fibre Supplementation in NAFLDNo drug interventionstreatment1recruiting
NCT03664596
Therapeutic And Dietary Effects Of The Sublimated Mare's Milk Supplement In Patients With Non-Alcoholic SteatohepatitistreatmentNot Availablecompleted
NCT05463796
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT05605158
Comparative Clinical Study Between Empagliflozin Versus Pioglitazone in Non-diabetic Patients With Non-alcoholic Steatohepatitistreatment3not_yet_recruiting
NCT04669158
Study of Oral Idebenone to Treat Non-Alcoholic Steatohepatitistreatment1 / 2active_not_recruiting
NCT03864835
NASH-FITTER: Nonalcoholic Steatohepatitis Fitness Intervention Treatment Targeting Endothelial Dysfunction ReversalNo drug interventionstreatmentNot Availablewithdrawn
NCT03400163
A Sub-study of BMS-986036 in Subjects With Non-Alcoholic Steatohepatitis (NASH)treatment2completed
NCT00977730
The Effect of Protandim on Non-alcoholic SteatohepatitisNo drug interventionstreatmentNot Availablecompleted
NCT05357248
Nutritional Cognitive Behavioral Therapy Feasibility Study in NAFLD and NASHNo drug interventionstreatmentNot Availablecompleted
NCT02314026
BREATHID Octanoate Breath Test With or Without Methacetin Breath Test for Correlation With Biopsy in NASHNo drug interventionsdiagnostic2completed
NCT04171765
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of BFKB8488A Compared With Placebo in Participants With Non-Alcoholic Steatohepatitistreatment2terminated
NCT03524365
Bariatric Surgery Versus Non-alcoholic Steato-hepatitisNo drug interventionstreatmentNot Availablecompleted
NCT04579874
Clinical Performance of LIVERFASt Test Compared w/ Liver Biopsy in Patients w/ NAFLD.No drug interventionsdiagnosticNot Availablecompleted
NCT06308874
Phase 1 Study to Investigate Safety, Tolerability, PK/PD of J2H-1702 in Healthy FemalesNo drug interventionstreatment1completed
NCT03863574
Saroglitazar Magnesium in the Treatment of Non-Alcoholic Steatohepatitistreatment2completed
NCT03437720
Assessment of the Safety and Effect of SAR425899 Versus Placebo for the Treatment of Non-alcoholic Fatty Liver DiseaseNo drug interventionstreatment2withdrawn
NCT02912260
Phase 2 Study of MGL-3196 in Patients With Non-Alcoholic Steatohepatitis (NASH)treatment2unknown_status
NCT05835180
A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Functiontreatment1completed
NCT04537780
Efficacy and Safety of Montelukast in Non Alcoholic Steatohepatitis (NASH)treatment4completed
NCT03812029
Safety, Tolerability, Pharmacokinetics and Efficacy of EYP001a in Patients With Nonalcoholic Steatohepatitis (NASH)treatment2completed
NCT02880189
EUS Guided Core Liver Biopsy and IGB Placement for the Diagnosis and Management of NASH and ObesityNo drug interventionssupportive_careNot Availablecompleted
NCT02784444
A Study to Evaluate the Safety, Tolerability & Efficacy of MSDC-0602K in Patients With NASHNo drug interventionstreatment2completed
NCT03803540
Fecal Microbiota Transplantation for the Treatment of Non-Alcoholic SteatohepatitisNo drug interventionstreatment1unknown_status
NCT05848440
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of AZD9550 Following Single Ascending Dose Administration to Healthy ParticipantsNo drug interventionstreatment1completed
NCT02787304
Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)treatment2terminated
NCT05573204
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients With Non-alcoholic Steatohepatitistreatment2active_not_recruiting
NCT02960204
Emricasan, an Oral Caspase Inhibitor, in Subjects With NASH Cirrhosis and Severe Portal Hypertensiontreatment2completed
NCT03198104
Assessing Kids for Liver Inflammation and Fibrosis Using Non-invasive MRINo drug interventionsNot AvailableNot Availablecompleted
NCT01674972
Glucose-induced Glucagon-like Peptide 1 (GLP-1) Secretion in NAFLD Patients Compared to Healthy ControlsNo drug interventionsNot AvailableNot Availablecompleted
NCT04182646
Effect of Adjustable Intragastric Balloon in Obese Non-alcoholic Fatty Liver DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT03734510
The Effect of Supplementation of Flaxseed, Hesperidin, Flaxseed and Hesperidin Together in Non-alcoholic Fatty Liver Disease: A Randomized, Controlled StudyNo drug interventionstreatmentNot Availableunknown_status
NCT05821010
Synbiotics and Fecal Microbiota Transplantation to Treat Non-Alcoholic Steatohepatitistreatment2recruiting
NCT04378010
A Randomized, Double-blind Study to Assess the Safety and Efficacy of EDP-305 in Subjects With Liver-biopsy Proven NASHNo drug interventionstreatment2terminated
NCT02681055
Open-Label Study To Evaluate MN-001 on HDL & Triglyceride in NASH & NAFLD Subjectstreatment2completed
NCT05623150
CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic SyndromeNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04657523
Ultrasound-Based Liver Fat Quantification (LFQ) Pilot StudyNo drug interventionsdiagnosticNot Availablecompleted
NCT03962608
Safety and Tolerability of Yaq-001 in Patients With Non-Alcoholic SteatohepatitisNo drug interventionstreatmentNot Availablewithdrawn
NCT04806750
Emricasan, an Oral Caspase Inhibitor, in Subjects With Non-Alcoholic Steatohepatitis (NASH) Cirrhosis and Severe Portal Hypertensiontreatment2completed