Coptisine

DB19308ExperimentalSmall molecule

Coptisine: Overview.

Mechanism: Pharmacologically active on Acetylcholinesterase, Caspase-1, and Aryl hydrocarbon receptor
Curator reviewed
Formula / weight: C₁₉H₁₄NO₄ · 320.323 g/mol (avg)
Also known as: 6,7-dihydrobis(1,3)benzodioxolo(5,6-a:4',5'-g)quinolizinium · 7,8,13,13a-tetradehydro-2,3:9,10-bismethylenedioxyberbinium · Alkaloid a, from coptis groenlandica · Berbinium, 7,8,13,13a-tetradehydro-2,3:9,10-bis(methylenedioxy)- · Bis(1,3)benzodioxolo(5,6-a:4',5'-g)quinolizinium, 6,7-dihydro-
Code names: YHL II

Resolves to

Compound

UNII0GCL71VN14CAS3486-66-6ChEMBLCHEMBL362071ChEBI67862KEGGC16938

Clinical / RWD

PharmGKBPA166153416

Structure

InChIKeyXYHOBCMEDLZUMP-UHFFFAOYSA-NSMILESC1OC2=CC3=C(C=C2O1)C1=[N+](CC3)C=C2C3=C(OCO3)C=CC2=C1

Targets

P22303ACHEP29466CASP1P35869AHR

Transporters

O15244SLC22A2O15245SLC22A1O75751SLC22A3

What you can answer from here — as of September 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3TransportersSubstrate / inhibitor direction, not just membership

Listed above

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Coptisine, and which of those have an active Phase 3 trial?

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