ATP-binding cassette sub-family C member 3

BE0001061ProteinHumansABCC3

ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. It is acted on by 33 drugs in DrugBank.

Gene name
ABCC3
UniProtKB entry
O15438Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
1,527 residues · 169,341 Da
Also known as
7.6.2.- · 7.6.2.2 · 7.6.2.3 · Canalicular multispecific organic anion transporter 2 · CMOAT2

Resolves to

Protein
UniProtO15438UniProt nameMRP3_HUMAN
Gene
HGNCHGNC:54NCBI Gene8714GenBank3132270GeneCardsABCC3
Pharmacology
KEGGhsa:8714
Structure
PDB8HVHPDB8HW2PDB8HW4
Drugs

What you can answer from here — as of September 03, 2024

33DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 3, how selective are they, and which programs against it are still in active trials?

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