Bile salt export pump

BE0000703ProteinHumansABCB11

Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently... It is acted on by 124 drugs in DrugBank.

Gene name
ABCB11
UniProtKB entry
O95342Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,321 residues · 146,406 Da
Also known as
7.6.2.- · ATP-binding cassette sub-family B member 11 · BSEP

Resolves to

Protein
UniProtO95342UniProt nameABCBB_HUMAN
Gene
HGNCHGNC:42NCBI Gene8647GenBank3873243GeneCardsABCB11
Pharmacology
IUPHAR/GtoPdb778KEGGhsa:8647
Structure
PDB6LR0PDB7DV5PDB7E1A
Drugs

What you can answer from here — as of September 07, 2019

124DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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264+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bile salt export pump, how selective are they, and which programs against it are still in active trials?

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