Aquaporin-7
Details
- Name
- Aquaporin-7
- Synonyms
- AQP-7
- AQP7L
- AQP9
- AQPap
- Aquaglyceroporin-7
- Aquaporin adipose
- Aquaporin-7-like
- Gene Name
- AQP7
- UniProtKB Entry
- O14520Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052496|Aquaporin-7 MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVL NKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQF LGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTG MLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIA GWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITV LPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF
- Number of residues
- 342
- Molecular Weight
- 37231.325
- Theoretical pI
- Not Available
- GO Classification
- Functionsglycerol channel activity / urea transmembrane transporter activity / water channel activityProcesseswater transportComponentscell cortex / cell-cell junction / cytoplasm / cytoplasmic vesicle membrane / lipid droplet / plasma membrane
- General Function
- Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:11952783, PubMed:30420639, PubMed:30423801, PubMed:9405233). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity)
- Specific Function
- Glycerol channel activity
- Pfam Domain Function
- MIP (PF00230)
- Signal Regions
- Not Available
- Transmembrane Regions
- 36-56 67-86 113-148 168-188 198-219
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052497|Aquaporin-7 (AQP7) ATGGTTCAAGCATCCGGGCACAGGCGGTCCACCCGTGGCTCCAAAATGGTCTCCTGGTCC GTGATAGCAAAGATCCAGGAAATACTGCAGAGGAAGATGGTGCGAGAGTTCCTGGCCGAG TTCATGAGCACATATGTCATGATGGTATTCGGCCTTGGTTCCGTGGCCCATATGGTTCTA AATAAAAAATATGGGAGCTACCTTGGTGTCAACTTGGGTTTTGGCTTCGGAGTCACCATG GGAGTGCACGTGGCAGGCCGCATCTCTGGAGCCCACATGAACGCAGCTGTGACCTTTGCT AACTGTGCGCTGGGCCGCGTGCCCTGGAGGAAGTTTCCGGTCTATGTGCTGGGGCAGTTC CTGGGCTCCTTCCTGGCGGCTGCCACCATCTACAGTCTCTTCTACACGGCCATTCTCCAC TTTTCGGGTGGACAGCTGATGGTGACCGGTCCCGTCGCTACAGCTGGCATTTTTGCCACC TACCTTCCTGATCACATGACATTGTGGCGGGGCTTCCTGAATGAGGCGTGGCTGACCGGG ATGCTCCAGCTGTGTCTCTTCGCCATCACGGACCAGGAGAACAACCCAGCACTGCCAGGA ACAGAGGCGCTGGTGATAGGCATCCTCGTGGTCATCATCGGGGTGTCCCTTGGCATGAAC ACAGGATATGCCATCAACCCGTCCCGGGACCTGCCCCCCCGCATCTTCACCTTCATTGCT GGTTGGGGCAAACAGGTCTTCAGCAATGGGGAGAACTGGTGGTGGGTGCCAGTGGTGGCA CCACTTCTGGGTGCCTATCTAGGTGGCATCATCTACCTGGTCTTCATTGGCTCCACCATC CCACGGGAGCCCCTGAAATTGGAGGATTCTGTGGCGTATGAAGACCACGGGATAACCGTA TTGCCCAAGATGGGATCTCATGAACCCACGATCTCTCCCCTCACCCCCGTCTCTGTGAGC CCTGCCAACAGATCTTCAGTCCACCCTGCCCCACCCTTACATGAATCCATGGCCCTAGAG CACTTCTAA
- Chromosome Location
- 9
- Locus
- 9p13.3
- External Identifiers
Resource Link UniProtKB ID O14520 UniProtKB Entry Name AQP7_HUMAN GeneCard ID AQP7 HGNC ID HGNC:640 PDB ID(s) 6KXW, 6N1G, 6QZI, 6QZJ, 8AMW, 8AMX, 8C9H KEGG ID hsa:364 NCBI Gene ID 364 - General References
- Kuriyama H, Kawamoto S, Ishida N, Ohno I, Mita S, Matsuzawa Y, Matsubara K, Okubo K: Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. Biochem Biophys Res Commun. 1997 Dec 8;241(1):53-8. [Article]
- Kondo H, Shimomura I, Kishida K, Kuriyama H, Makino Y, Nishizawa H, Matsuda M, Maeda N, Nagaretani H, Kihara S, Kurachi Y, Nakamura T, Funahashi T, Matsuzawa Y: Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. Eur J Biochem. 2002 Apr;269(7):1814-26. [Article]
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- Laforenza U, Pellavio G, Marchetti AL, Omes C, Todaro F, Gastaldi G: Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning. Int J Mol Sci. 2016 Dec 30;18(1). pii: ijms18010066. doi: 10.3390/ijms18010066. [Article]
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- Mosca AF, de Almeida A, Wragg D, Martins AP, Sabir F, Leoni S, Moura TF, Prista C, Casini A, Soveral G: Molecular Basis of Aquaporin-7 Permeability Regulation by pH. Cells. 2018 Nov 10;7(11). pii: cells7110207. doi: 10.3390/cells7110207. [Article]
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- Ceperuelo-Mallafre V, Miranda M, Chacon MR, Vilarrasa N, Megia A, Gutierrez C, Fernandez-Real JM, Gomez JM, Caubet E, Fruhbeck G, Vendrell J: Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. J Clin Endocrinol Metab. 2007 Sep;92(9):3640-5. Epub 2007 Jun 12. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Aquaporin-7 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Glycerin approved, investigational unknown transporter Details