Carboxypeptidase D

Details

Name

Carboxypeptidase D

Synonyms

• 3.4.17.22
• gp180
• Metallocarboxypeptidase D

Gene Name

CPD

Organism

Humans

Amino acid sequence

>lcl|BSEQ0009489|Carboxypeptidase D
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYH
EEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPD
AAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRA
LIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHP
IMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS
QLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFY
RLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTV
AIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYV
MEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRI
HLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMK
SYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPC
KNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQ
NRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTY
KITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTK
EFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLG
QSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPA
VTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAII
ENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSC
PNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADN
KRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNII
AIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIW
CICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH

Number of residues

1380

Molecular Weight

152929.865

Theoretical pI

Not Available

GO Classification

Functions

metallocarboxypeptidase activity / serine-type carboxypeptidase activity / zinc ion binding

Processes

peptide metabolic process / protein processing

Components

extracellular exosome / extracellular space / integral component of membrane / membrane / nucleus / trans-Golgi network

General Function

Zinc ion binding

Specific Function

Not Available

Pfam Domain Function

• Peptidase_M14 (PF00246)

Transmembrane Regions

1300-1320

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0019599|Carboxypeptidase D (CPD)
ATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTT
GATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTA
TTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCT
CATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGG
TATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATC
ACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAG
AACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTT
GTTAAAGATTCCATAACAGGATCTGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATT
AATCATAATATCACAACAGGCAGATTTGGTGATTTCTACCGATTACTTGTTCCTGGAACT
TACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTG
AAAGAAGGACCAGCCACAGAGGTGGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATC
CCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTTGCTATACCTAATATTCTTTCT
GGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCT
GATATGGAAATCTTCTTGAGAAGGTTTGCCAATGAATATCCTAACATTACCCGGCTTTAT
TCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTGATGGAGATATCTGATAATCCG
GGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAA
GTGGTTGGAAGAGAACTGCTGTTGAACCTCATAGAATACCTTTGTAAGAACTTTGGAACA
GACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATTCACCTTATGCCATCCATGAAT
CCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAAC
AGCAACAACTTTGACCTGAACCGAAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCT
ACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAGTCCTATCCATTTGTACTTTCA
GCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGA
CTTGCCACATATAGTAAATCACCAGATGATGCTGTGTTCCAACAAATAGCACTTTCTTAT
TCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGCAAGAATATGTATCCTAATGAA
TATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGAGGAATGCAG
GACTGGAACTATTTACAAACAAATTGCTTTGAAGTGACTATTGAACTAGGTTGTGTGAAA
TATCCACTTGAGAAAGAGCTGCCAAACTTTTGGGAACAGAATCGAAGATCACTAATCCAG
TTTATGAAACAGGTTCATCAGGGCGTCAGAGGATTTGTTCTAGATGCCACAGATGGCAGG
GGTATATTAAATGCCACCATTAGTGTTGCTGAGATTAATCACCCAGTGACTACTTACAAA
ACTGGAGATTACTGGCGTCTCTTGGTTCCAGGAACTTATAAAATCACAGCATCTGCTCGA
GGGTATAATCCAGTTACCAAGAATGTGACTGTCAAGAGTGAAGGCGCTATTCAGGTCAAC
TTCACACTTGTTCGATCCTCAACAGATTCAAACAATGAATCAAAGAAAGGAAAAGGGGCT
AGCAGCAGCACCAATGATGCCAGTGATCCAACTACTAAAGAGTTTGAAACTTTAATTAAA
GACCTTTCAGCGGAGAATGGTTTGGAAAGCCTCATGTTACGCTCCTCCTCAAATCTGGCT
CTGGCTCTTTATCGATACCATTCCTACAAAGACTTATCAGAGTTTCTGAGAGGACTTGTA
ATGAACTATCCACATATTACAAATCTTACCAATTTGGGACAGAGCACTGAATATCGTCAC
ATTTGGTCCCTTGAAATCTCCAATAAGCCCAATGTATCTGAGCCTGAAGAACCAAAGATT
CGTTTTGTTGCTGGTATCCATGGAAATGCGCCAGTTGGAACTGAACTGCTTTTGGCTCTG
GCAGAATTTCTCTGCCTGAACTACAAAAAGAACCCAGCTGTTACCCAATTGGTTGACAGG
ACTAGGATTGTGATTGTCCCTTCTCTAAATCCAGATGGGCGAGAGAGAGCTCAAGAGAAA
GACTGTACTTCAAAAATAGGACAAACAAATGCTCGTGGCAAAGATTTGGATACAGACTTC
ACAAATAATGCCTCCCAACCTGAGACCAAAGCCATCATTGAAAATTTGATTCAAAAACAG
GACTTTAGTCTTTCTGTTGCCTTAGATGGTGGTTCCATGCTGGTCACATATCCTTATGAC
AAGCCAGTACAGACAGTGGAAAATAAAGAGACTCTGAAGCATTTGGCATCTCTTTATGCA
AATAATCATCCATCCATGCACATGGGTCAGCCCAGTTGCCCAAATAAATCAGATGAGAAT
ATTCCAGGAGGAGTAATGCGTGGAGCAGAATGGCATAGTCACCTGGGCAGCATGAAGGAT
TATAGTGTCACCTATGGCCATTGTCCGGAAATCACAGTATACACAAGCTGCTGTTACTTT
CCTAGTGCTGCACGACTCCCTTCCTTGTGGGCAGACAATAAGAGATCTCTTCTTAGTATG
TTAGTGGAGGTTCACAAGGGAGTTCATGGATTTGTTAAAGATAAGACTGGAAAGCCAATC
TCTAAAGCAGTCATTGTACTTAATGAAGGAATAAAGGTACAAACAAAAGAGGGAGGTTAT
TTCCATGTACTCTTAGCGCCAGGTGTCCATAACATTATTGCCATCGCTGATGGGTACCAG
CAACAACATTCACAGGTCTTTGTGCATCATGATGCAGCTAGTTCTGTGGTGATAGTCTTT
GACACAGATAACCGGATATTTGGTTTGCCAAGGGAGCTTGTGGTAACTGTATCAGGTGCT
ACTATGTCGGCATTGATCCTAACAGCTTGCATTATTTGGTGCATCTGCTCAATCAAGTCT
AATAGACACAAGGATGGCTTTCATCGGCTCAGGCAGCATCATGATGAGTATGAAGATGAA
ATTCGCATGATGTCTACCGGCTCCAAGAAGTCCCTCCTAAGCCATGAGTTCCAGGATGAA
ACAGACACTGAAGAGGAAACATTATATTCTAGCAAACATTGA

Chromosome Location

17

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	O75976
UniProtKB Entry Name	CBPD_HUMAN
HGNC ID	HGNC:2301

General References

1. Ishikawa T, Murakami K, Kido Y, Ohnishi S, Yazaki Y, Harada F, Kuroki K: Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. Gene. 1998 Jul 30;215(2):361-70. [Article]
2. Tan F, Rehli M, Krause SW, Skidgel RA: Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. Biochem J. 1997 Oct 1;327 ( Pt 1):81-7. [Article]
3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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6. McGwire GB, Tan F, Michel B, Rehli M, Skidgel RA: Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. Life Sci. 1997;60(10):715-24. [Article]
7. Kalinina EV, Fricker LD: Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. J Biol Chem. 2003 Mar 14;278(11):9244-9. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04489	Guanidinoethylmercaptosuccinic acid	experimental	unknown		Details