The DNA sequence and analysis of human chromosome 6.

Article Details

Citation

Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S

The DNA sequence and analysis of human chromosome 6.

Nature. 2003 Oct 23;425(6960):805-11.

PubMed ID
14574404 [ View in PubMed
]
Abstract

Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire sequence has been subjected to high-quality manual annotation, resulting in the evidence-supported identification of 1,557 genes and 633 pseudogenes. Here we report that at least 96% of the protein-coding genes have been identified, as assessed by multi-species comparative sequence analysis, and provide evidence for the presence of further, otherwise unsupported exons/genes. Among these are genes directly implicated in cancer, schizophrenia, autoimmunity and many other diseases. Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we show that this cluster co-localizes with a region of high transcriptional activity. Within the essential immune loci of the major histocompatibility complex, we find HLA-B to be the most polymorphic gene on chromosome 6 and in the human genome.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Coagulation factor XIII A chainP00488Details
Phenylalanine--tRNA ligase, mitochondrialO95363Details
Cannabinoid receptor 1P21554Details
Retinoic acid receptor RXR-betaP28702Details
S-adenosylmethionine decarboxylase proenzymeP17707Details
Estrogen receptorP03372Details
Gamma-aminobutyric acid receptor subunit rho-1P24046Details
Succinate-semialdehyde dehydrogenase, mitochondrialP51649Details
Vascular endothelial growth factor AP15692Details
Glutamate--cysteine ligase catalytic subunitP48506Details
PlasminogenP00747Details
Gamma-aminobutyric acid type B receptor subunit 1Q9UBS5Details
Ribosyldihydronicotinamide dehydrogenase [quinone]P16083Details
Valine--tRNA ligaseP26640Details
Arginase-1P05089Details
Glycine N-methyltransferaseQ14749Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1P22413Details
5-hydroxytryptamine receptor 1EP28566Details
Estradiol 17-beta-dehydrogenase 8Q92506Details
NADP-dependent malic enzymeP48163Details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2O95865Details
cAMP-specific 3',5'-cyclic phosphodiesterase 7BQ9NP56Details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AQ9Y233Details
Interferon gamma receptor 1P15260Details
Mu-type opioid receptorP35372Details
Methylmalonyl-CoA mutase, mitochondrialP22033Details
5-hydroxytryptamine receptor 1BP28222Details
Glutathione S-transferase A3Q16772Details
Glutathione S-transferase A4O15217Details
Glutathione S-transferase A5Q7RTV2Details
Epididymal secretory glutathione peroxidaseO75715Details
Metabotropic glutamate receptor 1Q13255Details
Glutamate receptor ionotropic, kainate 2Q13002Details
Metabotropic glutamate receptor 4Q14833Details
Tyrosine-protein kinase FynP06241Details
Glucagon-like peptide 1 receptorP43220Details
Lactoylglutathione lyaseQ04760Details
Thiopurine S-methyltransferaseP51580Details
Peroxisome proliferator-activated receptor deltaQ03181Details
Mitogen-activated protein kinase 14Q16539Details
Trace amine-associated receptor 1Q96RJ0Details
Gap junction alpha-1 proteinP17302Details
5'-nucleotidaseP21589Details
Epithelial discoidin domain-containing receptor 1Q08345Details
Protein-L-isoaspartate(D-aspartate) O-methyltransferaseP22061Details
Equilibrative nucleoside transporter 1Q99808Details
Serine/threonine-protein kinase pim-1P11309Details
Apolipoprotein(a)P08519Details
Triggering receptor expressed on myeloid cells 1Q9NP99Details
Acetyl-CoA acetyltransferase, cytosolicQ9BWD1Details
GMP reductase 1P36959Details
Complement factor BP00751Details
Fatty acid-binding protein, brainO15540Details
Heat shock protein HSP 90-betaP08238Details
HLA class II histocompatibility antigen, DQ alpha 2 chainP01906Details
Serpin B6P35237Details
Prolyl endopeptidaseP48147Details
Choline transporter-like protein 4Q53GD3Details
Glutathione S-transferase A2P09210Details
Elongation of very long chain fatty acids protein 4Q9GZR5Details
LengsinQ5TDP6Details
Glutathione S-transferase A1P08263Details
Glutathione peroxidase 6P59796Details
Alanine--tRNA ligase, mitochondrialQ5JTZ9Details
Proteasome subunit beta type-1P20618Details
Histone deacetylase 2Q92769Details
Potassium voltage-gated channel subfamily KQT member 5Q9NR82Details
Platelet-activating factor acetylhydrolaseQ13093Details
Adhesion G-protein coupled receptor F1Q5T601Details
Antigen peptide transporter 1Q03518Details
GDP-mannose 4,6 dehydrataseO60547Details
NAD-dependent protein deacylase sirtuin-5, mitochondrialQ9NXA8Details
Endothelin-1P05305Details
Mitogen-activated protein kinase 13O15264Details
Tubulin beta-2A chainQ13885Details
Tubulin beta-2B chainQ9BVA1Details
PromotilinP12872Details
HLA class I histocompatibility antigen, A-3 alpha chainP04439Details
Transcriptional activator MybP10242Details
Gamma-aminobutyric acid receptor subunit rho-2P28476Details
Cation-independent mannose-6-phosphate receptorP11717Details
Solute carrier family 22 member 7Q9Y694Details
Solute carrier family 22 member 2O15244Details
Solute carrier family 22 member 1O15245Details
Solute carrier family 22 member 3O75751Details
Multidrug resistance-associated protein 7Q5T3U5Details
Monocarboxylate transporter 10Q8TF71Details
POU domain, class 5, transcription factor 1Q01860Details
Solute carrier family 22 member 16Q86VW1Details
Tubulin epsilon chainQ9UJT0Details
Dual specificity protein kinase TTKP33981Details
ColipaseP04118Details
Serine/threonine-protein kinase Sgk1O00141Details
Ephrin type-A receptor 7Q15375Details
Enoyl-CoA delta isomerase 2, mitochondrialO75521Details
Guanylyl cyclase-activating protein 1P43080Details
Apolipoprotein MO95445Details
AfadinP55196Details
Valacyclovir hydrolaseQ86WA6Details
Iodotyrosine deiodinase 1Q6PHW0Details
Acyl-coenzyme A thioesterase 13Q9NPJ3Details
mRNA-capping enzymeO60942Details
Superoxide dismutase [Mn], mitochondrialP04179Details
HLA class II histocompatibility antigen, DQ beta 1 chainP01920Details
Sorting nexin-3O60493Details
Spliceosome RNA helicase DDX39BQ13838Details
Complement C4-AP0C0L4Details
Complement C4-BP0C0L5Details
Proteasome subunit beta type-9P28065Details
Proteasome subunit beta type-8P28062Details
Tyrosine-protein kinase FRKP42685Details
Steroid 21-hydroxylaseP08686Details
Inositol 1,4,5-trisphosphate receptor type 3Q14573Details
Histone H1.4P10412Details
Histone H2B type 1-C/E/F/G/IP62807Details
Solute carrier family 2, facilitated glucose transporter member 12Q8TD20Details
Chloride intracellular channel protein 1O00299Details
Casein kinase II subunit betaP67870Details
UtrophinP46939Details
Interleukin-17AQ16552Details
Orexin receptor type 2O43614Details
Serpin B9P50453Details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1Q8N1G2Details
Cyclin-dependent kinase inhibitor 1P38936Details
DesmoplakinP15924Details
40S ribosomal protein S18P62269Details
Elongation of very long chain fatty acids protein 5Q9NYP7Details
Serine/threonine-protein kinase 38Q15208Details
Serine/threonine-protein kinase ICKQ9UPZ9Details
Mitogen-activated protein kinase kinase kinase 4Q9Y6R4Details
Myosin light chain kinase family member 4Q86YV6Details
Serine/threonine-protein kinase PRP4 homologQ13523Details
Receptor-interacting serine/threonine-protein kinase 1Q13546Details
Proto-oncogene tyrosine-protein kinase ROSP08922Details
Phosphoglycerate kinase 2P07205Details
HLA class II histocompatibility antigen, DR alpha chainP01903Details
HLA class II histocompatibility antigen, DRB1-15 beta chainP01911Details
HLA class II histocompatibility antigen, DR beta 3 chainP79483Details
HLA class II histocompatibility antigen, DR beta 4 chainP13762Details
HLA class II histocompatibility antigen, DR beta 5 chainQ30154Details
Magnesium transporter MRS2 homolog, mitochondrialQ9HD23Details
Zinc transporter SLC39A7Q92504Details
Elongation of very long chain fatty acids protein 2Q9NXB9Details
V-type proton ATPase subunit G 2O95670Details
Advanced glycosylation end product-specific receptorQ15109Details
MHC class I chain-related protein AQ96QC4Details
HLA class I histocompatibility antigen, alpha chain EP13747Details
HLA class I histocompatibility antigen, alpha chain FP30511Details
HLA class I histocompatibility antigen, C alpha chainP10321Details