The DNA sequence and analysis of human chromosome 6.
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Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
The DNA sequence and analysis of human chromosome 6.
Nature. 2003 Oct 23;425(6960):805-11.
- PubMed ID
- 14574404 [ View in PubMed]
- Abstract
Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire sequence has been subjected to high-quality manual annotation, resulting in the evidence-supported identification of 1,557 genes and 633 pseudogenes. Here we report that at least 96% of the protein-coding genes have been identified, as assessed by multi-species comparative sequence analysis, and provide evidence for the presence of further, otherwise unsupported exons/genes. Among these are genes directly implicated in cancer, schizophrenia, autoimmunity and many other diseases. Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we show that this cluster co-localizes with a region of high transcriptional activity. Within the essential immune loci of the major histocompatibility complex, we find HLA-B to be the most polymorphic gene on chromosome 6 and in the human genome.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Coagulation factor XIII A chain P00488 Details Phenylalanine--tRNA ligase, mitochondrial O95363 Details Cannabinoid receptor 1 P21554 Details Retinoic acid receptor RXR-beta P28702 Details S-adenosylmethionine decarboxylase proenzyme P17707 Details Estrogen receptor P03372 Details Gamma-aminobutyric acid receptor subunit rho-1 P24046 Details Succinate-semialdehyde dehydrogenase, mitochondrial P51649 Details Vascular endothelial growth factor A, long form P15692 Details Glutamate--cysteine ligase catalytic subunit P48506 Details Plasminogen P00747 Details Gamma-aminobutyric acid type B receptor subunit 1 Q9UBS5 Details Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 Details Valine--tRNA ligase P26640 Details Arginase-1 P05089 Details Glycine N-methyltransferase Q14749 Details Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 P22413 Details 5-hydroxytryptamine receptor 1E P28566 Details (3R)-3-hydroxyacyl-CoA dehydrogenase Q92506 Details NADP-dependent malic enzyme P48163 Details Putative hydrolase DDAH2 O95865 Details 3',5'-cyclic-AMP phosphodiesterase 7B Q9NP56 Details cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 Details Interferon gamma receptor 1 P15260 Details Mu-type opioid receptor P35372 Details Methylmalonyl-CoA mutase, mitochondrial P22033 Details 5-hydroxytryptamine receptor 1B P28222 Details Glutathione S-transferase A3 Q16772 Details Glutathione S-transferase A4 O15217 Details Glutathione S-transferase A5 Q7RTV2 Details Epididymal secretory glutathione peroxidase O75715 Details Metabotropic glutamate receptor 1 Q13255 Details Glutamate receptor ionotropic, kainate 2 Q13002 Details Metabotropic glutamate receptor 4 Q14833 Details Tyrosine-protein kinase Fyn P06241 Details Glucagon-like peptide 1 receptor P43220 Details Lactoylglutathione lyase Q04760 Details Thiopurine S-methyltransferase P51580 Details Peroxisome proliferator-activated receptor delta Q03181 Details Mitogen-activated protein kinase 14 Q16539 Details Trace amine-associated receptor 1 Q96RJ0 Details Gap junction alpha-1 protein P17302 Details 5'-nucleotidase P21589 Details Epithelial discoidin domain-containing receptor 1 Q08345 Details Protein-L-isoaspartate(D-aspartate) O-methyltransferase P22061 Details Equilibrative nucleoside transporter 1 Q99808 Details Serine/threonine-protein kinase pim-1 P11309 Details Apolipoprotein(a) P08519 Details Triggering receptor expressed on myeloid cells 1 Q9NP99 Details Acetyl-CoA acetyltransferase, cytosolic Q9BWD1 Details GMP reductase 1 P36959 Details Complement factor B P00751 Details Fatty acid-binding protein, brain O15540 Details Heat shock protein HSP 90-beta P08238 Details HLA class II histocompatibility antigen, DQ alpha 2 chain P01906 Details Serpin B6 P35237 Details Prolyl endopeptidase P48147 Details Choline transporter-like protein 4 Q53GD3 Details Glutathione S-transferase A2 P09210 Details Very long chain fatty acid elongase 4 Q9GZR5 Details Lengsin Q5TDP6 Details Glutathione S-transferase A1 P08263 Details Glutathione peroxidase 6 P59796 Details Alanine--tRNA ligase, mitochondrial Q5JTZ9 Details Proteasome subunit beta type-1 P20618 Details Histone deacetylase 2 Q92769 Details Potassium voltage-gated channel subfamily KQT member 5 Q9NR82 Details Platelet-activating factor acetylhydrolase Q13093 Details Adhesion G-protein coupled receptor F1 Q5T601 Details Antigen peptide transporter 1 Q03518 Details GDP-mannose 4,6 dehydratase O60547 Details NAD-dependent protein deacylase sirtuin-5, mitochondrial Q9NXA8 Details Endothelin-1 P05305 Details Mitogen-activated protein kinase 13 O15264 Details Tubulin beta-2A chain Q13885 Details Tubulin beta-2B chain Q9BVA1 Details Promotilin P12872 Details HLA class I histocompatibility antigen, A-3 alpha chain P04439 Details Transcriptional activator Myb P10242 Details Gamma-aminobutyric acid receptor subunit rho-2 P28476 Details Cation-independent mannose-6-phosphate receptor P11717 Details Solute carrier family 22 member 7 Q9Y694 Details Solute carrier family 22 member 2 O15244 Details Solute carrier family 22 member 1 O15245 Details Solute carrier family 22 member 3 O75751 Details ATP-binding cassette sub-family C member 10 Q5T3U5 Details Monocarboxylate transporter 10 Q8TF71 Details POU domain, class 5, transcription factor 1 Q01860 Details Solute carrier family 22 member 16 Q86VW1 Details Tubulin epsilon chain Q9UJT0 Details Dual specificity protein kinase TTK P33981 Details Colipase P04118 Details Serine/threonine-protein kinase Sgk1 O00141 Details Ephrin type-A receptor 7 Q15375 Details Enoyl-CoA delta isomerase 2 O75521 Details Guanylyl cyclase-activating protein 1 P43080 Details Apolipoprotein M O95445 Details Afadin P55196 Details Valacyclovir hydrolase Q86WA6 Details Iodotyrosine deiodinase 1 Q6PHW0 Details Acyl-coenzyme A thioesterase 13 Q9NPJ3 Details mRNA-capping enzyme O60942 Details Superoxide dismutase [Mn], mitochondrial P04179 Details HLA class II histocompatibility antigen, DQ beta 1 chain P01920 Details Sorting nexin-3 O60493 Details Spliceosome RNA helicase DDX39B Q13838 Details Complement C4-A P0C0L4 Details Complement C4-B P0C0L5 Details Proteasome subunit beta type-9 P28065 Details Proteasome subunit beta type-8 P28062 Details Tyrosine-protein kinase FRK P42685 Details Steroid 21-hydroxylase P08686 Details Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 Q14573 Details Histone H1.4 P10412 Details Histone H2B type 1-C/E/F/G/I P62807 Details Solute carrier family 2, facilitated glucose transporter member 12 Q8TD20 Details Chloride intracellular channel protein 1 O00299 Details Casein kinase II subunit beta P67870 Details Utrophin P46939 Details Interleukin-17A Q16552 Details Orexin receptor type 2 O43614 Details Serpin B9 P50453 Details Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Q8N1G2 Details Cyclin-dependent kinase inhibitor 1 P38936 Details Desmoplakin P15924 Details Small ribosomal subunit protein uS13 P62269 Details Very long chain fatty acid elongase 5 Q9NYP7 Details Serine/threonine-protein kinase 38 Q15208 Details Serine/threonine-protein kinase ICK Q9UPZ9 Details Mitogen-activated protein kinase kinase kinase 4 Q9Y6R4 Details Myosin light chain kinase family member 4 Q86YV6 Details Serine/threonine-protein kinase PRP4 homolog Q13523 Details Receptor-interacting serine/threonine-protein kinase 1 Q13546 Details Proto-oncogene tyrosine-protein kinase ROS P08922 Details Phosphoglycerate kinase 2 P07205 Details HLA class II histocompatibility antigen, DR alpha chain P01903 Details HLA class II histocompatibility antigen, DRB1-15 beta chain P01911 Details HLA class II histocompatibility antigen, DR beta 3 chain P79483 Details HLA class II histocompatibility antigen, DR beta 4 chain P13762 Details HLA class II histocompatibility antigen, DR beta 5 chain Q30154 Details Magnesium transporter MRS2 homolog, mitochondrial Q9HD23 Details Zinc transporter SLC39A7 Q92504 Details Very long chain fatty acid elongase 2 Q9NXB9 Details V-type proton ATPase subunit G 2 O95670 Details Advanced glycosylation end product-specific receptor Q15109 Details MHC class I chain-related protein A Q96QC4 Details HLA class I histocompatibility antigen, alpha chain E P13747 Details HLA class I histocompatibility antigen, alpha chain F P30511 Details HLA class I histocompatibility antigen, C alpha chain P10321 Details Runt-related transcription factor 2 Q13950 Details G1/S-specific cyclin-D3 P30281 Details Interleukin-17F Q96PD4 Details