tRNA (guanine-N(1)-)-methyltransferase
Details
- Name
- tRNA (guanine-N(1)-)-methyltransferase
- Synonyms
- 2.1.1.228
- M1G-methyltransferase
- tRNA [GM37] methyltransferase
- Gene Name
- trmD
- UniProtKB Entry
- P43912Swiss-Prot
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- NCBI Taxonomy ID
- 71421
- Amino acid sequence
>lcl|BSEQ0011801|tRNA (guanine-N(1)-)-methyltransferase MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGM LMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDE RLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPH YTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEA QAEHNS
- Number of residues
- 246
- Molecular Weight
- 27542.435
- Theoretical pI
- 5.65
- GO Classification
- FunctionstRNA (guanine(37)-N(1))-methyltransferase activityComponentscytoplasm
- General Function
- Trna (guanine(37)-n(1))-methyltransferase activity
- Specific Function
- Specifically methylates guanosine-37 in various tRNAs.
- Pfam Domain Function
- tRNA_m1G_MT (PF01746)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011802|tRNA (guanine-N(1)-)-methyltransferase (trmD) ATGTGGATAGGGGTAATTTCATTATTCCCCGAAATGTTTAAAGCAATTACGGAATTTGGG GTTACAGGTAGAGCCGTAAAACATAATCTTCTGAAAGTTGAATGTTGGAATCCAAGAGAT TTTACATTCGACAAGCATAAAACCGTGGACGATCGCCCTTATGGTGGTGGCCCAGGAATG CTAATGATGGTGCAACCTTTACGGGATGCGATTCATACTGCAAAAGCTGCGGCAGGAGAA GGCGCAAAGGTGATTTACCTTTCGCCACAAGGACGTAAACTCGATCAAGGCGGCGTAACC GAGCTTGCTCAAAATCAGAAATTGATTTTAGTATGTGGACGTTACGAAGGGATTGATGAA CGGTTGATTCAAACTGAAATTGATGAAGAATGGTCAATCGGCGATTACGTTCTGACCGGT GGGGAATTGCCGGCAATGACATTAATTGATGCTGTTGCACGTTTTATTCCCGGTGTATTA GGCAAACAAGCCTCGGCAGAAGAAGATTCTTTTGCAGATGGTTTATTAGATTGCCCGCAT TACACTAGACCAGAAGTGTTAGAAGGATTAACTGTACCACCCGTGCTGATGTCGGGACAT CACGAAGAAATTCGGAAATGGCGATTAAAACAATCGCTACAGAGAACGTGGCTCCGACGC CCTGAGCTCTTAGAAGGCCTAGCTCTGACTGACGAACAACGTAAGCTGTTAAAAGAGGCG CAAGCCGAGCATAACAGTTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P43912 UniProtKB Entry Name TRMD_HAEIN GenBank Gene ID L42023 PDB ID(s) 1UAJ, 1UAK, 1UAL, 1UAM, 3AXZ, 4MCB, 4MCC, 4MCD, 4YQD, 4YVG, 4YVH, 4YVI, 4YVJ, 4YVK KEGG ID hin:HI0202 NCBI Gene ID 951111 - General References
- Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
- Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK: Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition. EMBO J. 2003 Jun 2;22(11):2593-603. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type tRNA (guanine-N(1)-)-methyltransferase (Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details S-adenosyl-L-homocysteine experimental unknown target Details