Glutamate receptor ionotropic, kainate 5
Details
- Name
- Glutamate receptor ionotropic, kainate 5
- Synonyms
- EAA2
- Excitatory amino acid receptor 2
- GluK5
- Glutamate receptor KA-2
- GRIK2
- KA2
- Gene Name
- GRIK5
- UniProtKB Entry
- Q16478Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037087|Glutamate receptor ionotropic, kainate 5 MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK ARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKV GPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRG FLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFY KYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGP ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD PFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPV GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFL LESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR KWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAG SAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEA TSPPRPRPGPAGPRELAEHE
- Number of residues
- 980
- Molecular Weight
- 109263.695
- Theoretical pI
- 8.03
- GO Classification
- Functionsligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialProcessesmodulation of chemical synaptic transmission / regulation of synaptic vesicle fusion to presynaptic active zone membraneComponentscell projection / hippocampal mossy fiber to CA3 synapse / nucleoplasm / postsynaptic density membrane
- General Function
- Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1 and GRIK2 subunits (PubMed:1321949, PubMed:14511640, PubMed:8730589). Can form functional heteromeric receptors with GRIK3 (By similarity)
- Specific Function
- kainate selective glutamate receptor activity
- Pfam Domain Function
- Signal Regions
- 1-14
- Transmembrane Regions
- 545-565 623-643 804-824
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010585|Glutamate receptor ionotropic, kainate 5 (GRIK5) ATGCCGGCTGAGCTGCTGCTGCTGCTGATTGTTGCCTTCGCCAGCCCCAGCTGCCAGGTG CTCTCATCACTGCGCATGGCTGCAATCCTGGATGATCAGACAGTGTGTGGCCGCGGTGAG CGTCTGGCCTTGGCCTTGGCCCGGGAGCAGATCAACGGGATCATCGAGGTCCCAGCCAAG GCCCGAGTGGAAGTAGACATCTTTGAGCTGCAGCGGGACAGCCAGTACGAGACCACGGAC ACCATGTGTCAGATCTTACCCAAAGGGGTTGTGTCTGTCCTTGGGCCCTCCTCTAGCCCA GCATCTGCCTCCACCGTGAGCCATATCTGTGGAGAGAAGGAGATCCCCCACATCAAGGTG GGTCCCGAGGAGACACCCCGCCTTCAGTACCTTCGCTTCGCGTCTGTCAGCCTGTACCCC AGTAACGAGGACGTCAGCTTGGCGGTCTCCCGAATCCTCAAGTCCTTCAACTACCCCTCG GCCAGCCTCATCTGCGCCAAGGCTGAGTGCCTGCTGCGATTGGAGGAACTGGTGCGTGGC TTCCTCATCTCCAAGGAGACGCTGTCAGTGAGGATGTTGGACGACAGCCGGGACCCCACA CCACTGCTCAAGGAGATCCGTGATGACAAGGTGTCCACCATCATCATCGACGCCAACGCC TCCATCTCCCACCTCATCCTCCGTAAGGCCTCGGAACTGGGAATGACCTCAGCGTTTTAC AAGTACATCCTCACCACCATGGACTTCCCCATCCTGCATCTGGACGGTATTGTGGAGGAC TCCTCCAACATCCTGGGCTTCTCCATGTTCAACACGTCCCACCCCTTCTACCCTGAGTTT GTCCGCAGCCTCAACATGTCCTGGAGGGAGAACTGTGAAGCCAGCACCTACCTGGGCCCT GCGCTGTCAGCCGCCCTGATGTTTGACGCCGTGCACGTGGTGGTGAGCGCTGTCCGAGAG CTGAACCGCAGCCAGGAGATCGGTGTGAAGCCTCTGGCCTGTACATCGGCCAACATTTGG CCCCACGGGACCAGCCTCATGAACTACCTGCGCATGGTAGAGTATGATGGGCTGACCGGG CGGGTCGAGTTCAACAGCAAAGGGCAGAGAACCAACTACACCCTGCGCATCCTAGAAAAG TCCCGGCAGGGCCACCGTGAGATTGGGGTGTGGTACTCTAACCGCACCCTGGCCATGAAT GCCACCACCCTGGACATCAACCTGTCGCAGACACTGGCCAACAAGACCCTGGTGGTCACA ACCATCCTGGAGAACCCATACGTCATGCGCCGGCCCAACTTCCAGGCCCTGTCGGGGAAC GAACGCTTCGAGGGCTTCTGCGTGGACATGCTGCGGGAGCTGGCCGAGCTGCTGCGCTTC CGCTACCGCCTGCGGTTGGTGGAGGATGGGCTGTACGGGGCGCCCGAGCCCAACGGCTCC TGGACGGGCATGGTTGGCGAGCTCATCAACCGGAAGGCAGACCTGGCTGTGGCCGCCTTC ACCATCACAGCTGAGCGGGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACCCTGGGG ATCAGCATCCTCTACCGAGTGCACATGGGCCGCAAGCCTGGCTACTTCTCCTTCCTGGAC CCCTTCTCCCCTGCTGTGTGGCTCTTCATGCTTCTTGCCTACCTGGCTGTCAGCTGCGTC CTGTTTCTGGCTGCCAGGCTGAGCCCCTATGAGTGGTATAACCCACACCCATGCCTGCGG GCACGCCCCCACATCCTGGAGAACCAGTACACGCTGGGCAACAGCCTGTGGTTTCCCGTG GGGGGCTTCATGCAGCAGGGCTCGGAGATCATGCCCCGGGCGCTGTCCACGCGCTGTGTC AGCGGAGTCTGGTGGGCCTTCACCTTGATCATCATCTCCTCCTACACGGCCAACCTGGCC GCCTTCCTCACCGTGCAGCGCATGGAGGTGCCTGTGGAGTCGGCCGATGACCTGGCAGAT CAGACCAACATCGAGTATGGCACCATCCACGCCGGCTCCACCATGACCTTCTTCCAGAAT TCACGGTACCAAACGTACCAGCGCATGTGGAACTACATGCAGTCGAAGCAGCCCAGCGTG TTCGTCAAGAGCACAGAAGAGGGCATTGCCCGCGTCCTCAACTCCCGCTACGCCTTCCTG CTCGAGTCCACCATGAACGAATACCACCGGCGCCTCAACTGCAACCTCACCCAGATCGGG GGACTCCTCGACACCAAGGGCTACGGCATTGGCATGCCGCTGGGCTCCCCGTTCCGGGAT GAGATCACACTGGCCATCCTGCAGCTTCAGGAGAACAACCGGCTGGAGATCCTGAAGCGC AAGTGGTGGGAGGGGGGCCGGTGCCCCAAGGAGGAGGACCATCGAGCTAAAGGTTTGGGC ATGGAGAACATTGGTGGCATTTTTATCGTGCTCATCTGTGGCCTCATCATTGCTGTCTTC GTGGCGGTCATGGAATTCATATGGTCCACACGGAGGTCAGCTGAGTCCGAGGAGACCCCA GCTCTGCATCCAGCTGCCTGCCAGTGTTCTGCACTTGGCCCAAGGACTCCTCTGAAGGAG CCGTCCATGCTGCTAGTAAAGGTGCCCTCCACCCGTGTCCAGGTTGCCTTCTCAAGGACA TCCCTCCGGCAAGTCTGTCCTTTCCTCCTGCAGCATCAGTTGTCCTCTCTTTATTGGATT CAGGCCACCAACGTACAAATATGCTGTCATTTCTCCAGTCTTAAACCCTCTCCTGACCTC ACTTTCCCTCCCAGCCACCGCCCACTTTCTTCCCTTCTCTTTACAGCCTTGGCAGCAGTG GGGGGTCTCCCTGATGCTTCCAGTTTCTTCTTTCCTCCCATTTCCTCTTGCCCCCCACTC CAGTCTGGCATCGGTCCCTGCCACTCCACTGAAGCCACTCTTGTCACCAGCAACTTCCAT GTCTGA
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID Q16478 UniProtKB Entry Name GRIK5_HUMAN GenBank Protein ID 251840 GenBank Gene ID S40369 GeneCard ID GRIK5 GenAtlas ID GRIK5 HGNC ID HGNC:4583 KEGG ID hsa:2901 NCBI Gene ID 2901 - General References
- Kamboj RK, Schoepp DD, Nutt S, Shekter L, Korczak B, True RA, Zimmerman DM, Wosnick MA: Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. Mol Pharmacol. 1992 Jul;42(1):10-5. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Glutamate receptor ionotropic, kainate 5 (Humans) protein primaryKainate receptors (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Glutamic acid approved, nutraceutical unknown target Details Butabarbital approved, illicit unknown target antagonist Details Topiramate approved yes target antagonist Details