Guanylate kinase

Details

Name
Guanylate kinase
Synonyms
  • 2.7.4.8
  • GMK
  • GMP kinase
Gene Name
GUK1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004617|Guanylate kinase
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
LKEALSEEIKKAQRTGA
Number of residues
197
Molecular Weight
21725.41
Theoretical pI
6.53
GO Classification
Functions
ATP binding / guanylate kinase activity
Processes
ATP metabolic process / dATP metabolic process / dGDP biosynthetic process / dGMP metabolic process / drug metabolic process / GDP biosynthetic process / GDP-mannose metabolic process / glycoprotein transport / nucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / purine nucleotide metabolic process / small molecule metabolic process
Components
cytosol
General Function
Guanylate kinase activity
Specific Function
Essential for recycling GMP and indirectly, cGMP.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011690|Guanylate kinase (GUK1)
ATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCACCCTG
CTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACG
AGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTG
ATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCCGAGTTCTCGGGGAACCTG
TATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTG
GACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATC
TCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTGCGGCAGCGCAACACTGAA
ACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCAGCAAG
GAGCCCGGCCTGTTTGATGTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAG
CTGAAGGAGGCGCTCTCTGAGGAAATCAAGAAAGCTCAAAGGACCGGCGCCTGA
Chromosome Location
1
Locus
1q32-q41
External Identifiers
ResourceLink
UniProtKB IDQ16774
UniProtKB Entry NameKGUA_HUMAN
GenBank Protein ID1196436
GenBank Gene IDL76200
GenAtlas IDGUK1
HGNC IDHGNC:4693
General References
  1. Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM: Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation. FEBS Lett. 1996 May 6;385(3):185-8. [Article]
  2. Brady WA, Kokoris MS, Fitzgibbon M, Black ME: Cloning, characterization, and modeling of mouse and human guanylate kinases. J Biol Chem. 1996 Jul 12;271(28):16734-40. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01972Guanosine-5'-MonophosphateexperimentalunknownDetails
DB00577Valaciclovirapproved, investigationalunknownsubstrateDetails
DB00787AcyclovirapprovedyessubstrateDetails