Zinc transporter ZIP12
Details
- Name
- Zinc transporter ZIP12
- Synonyms
- LIV-1 subfamily of ZIP zinc transporter 8
- LZT-Hs8
- Solute carrier family 39 member 12
- ZIP-12
- ZIP12
- Zrt- and Irt-like protein 12
- Gene Name
- SLC39A12
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052357|Zinc transporter ZIP12 MCFRTKLSVSWVPLFLLLSRVFSTETDKPSAQDSRSRGSSGQPADLLQVLSAGDHPPHNH SRSLIKTLLEKTGCPRRRNGMQGDCNLCFEPDALLLIAGGNFEDQLREEVVQRVSLLLLY YIIHQEEICSSKLNMSNKEYKFYLHSLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQS QCMETKTLQKKSGIVSSEGANESTLPQLAAMIITLSLQGVCLGQGNLPSPDYFTEYIFSS LNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQNNIITHDQDYSNFSSSMEKESE DGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSCHLPKDQQAKLP PTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSCEENYRLILQLFVGLAVGTLSGDALLHL IPQVLGLHKQEAPEFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILLVSPNDKQGLSLV NGHVGHSHHLALNSELSDQAGRGKSASTIQLKSPEDSQAAEMPIGSMTASNRKCKAISLL AIMILVGDSLHNFADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMK TAILMNFISSLTAFMGLYIGLSVSADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQR PWMMFLLQNFGLILGWLSLLLLAIYEQNIKI
- Number of residues
- 691
- Molecular Weight
- 76665.43
- Theoretical pI
- Not Available
- GO Classification
- Functionszinc ion transmembrane transporter activityProcessescellular zinc ion homeostasis / regulation of microtubule polymerization / regulation of neuron projection development / signal transduction / zinc ion import across plasma membraneComponentscell / extracellular vesicle / integral component of plasma membrane / perinuclear region of cytoplasm
- General Function
- Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.
- Specific Function
- Zinc ion transmembrane transporter activity
- Pfam Domain Function
- Transmembrane Regions
- 203-223 370-390 399-419 449-469 539-559 603-623 632-652 664-684
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052358|Zinc transporter ZIP12 (SLC39A12) ATGTGCTTCCGGACAAAGCTCTCAGTATCCTGGGTGCCATTGTTTCTTCTACTCAGCCGT GTTTTTTCTACTGAGACAGACAAACCCTCAGCCCAGGATAGCAGAAGCCGTGGGAGTTCA GGCCAACCGGCAGACCTGCTACAGGTTCTCTCTGCTGGTGACCACCCACCCCACAACCAC TCAAGAAGCCTCATCAAAACATTGTTGGAGAAAACTGGGTGCCCACGGAGGAGAAACGGA ATGCAAGGAGATTGCAATCTGTGCTTTGAACCAGATGCACTATTACTAATAGCTGGAGGA AATTTTGAAGATCAGCTTAGAGAAGAAGTGGTCCAGAGAGTTTCTCTTCTCCTTCTCTAT TACATTATTCATCAGGAAGAGATCTGTTCTTCAAAGCTCAACATGAGTAATAAAGAGTAT AAATTTTACCTACACAGCCTACTGAGCCTCAGGCAGGATGAAGATTCCTCTTTCCTTTCA CAGAATGAGACAGAAGATATCTTGGCTTTCACCAGGCAGTACTTTGACACTTCTCAAAGC CAGTGTATGGAAACCAAAACGCTGCAGAAAAAATCTGGAATAGTGAGCAGTGAAGGTGCT AATGAAAGTACGCTTCCTCAGTTGGCAGCCATGATCATTACTTTGTCCCTCCAGGGTGTT TGTCTGGGACAAGGAAACTTGCCTTCCCCAGACTACTTTACAGAATATATTTTCAGTTCC TTGAATCGTACGAATACCCTCCGCCTATCAGAACTAGACCAACTCCTCAACACTCTCTGG ACCAGAAGTACTTGTATCAAAAATGAGAAAATCCATCAATTTCAAAGGAAACAAAACAAC ATAATAACCCATGATCAGGACTATTCTAATTTCTCTTCATCCATGGAAAAAGAGTCTGAG GATGGTCCAGTTTCCTGGGATCAGACCTGCTTCTCTGCTAGGCAGCTGGTGGAGATATTT CTACAGAAGGGCCTCTCACTCATTTCTAAGGAGGACTTTAAGCAAATGAGTCCAGGGATC ATCCAGCAGCTCCTCAGCTGCTCCTGCCACTTACCCAAGGACCAACAAGCAAAGCTGCCA CCTACCACTCTGGAGAAATACGGCTACAGCACGGTGGCTGTCACCCTTCTCACACTGGGC TCCATGCTGGGGACAGCGCTGGTCCTTTTCCATAGCTGTGAGGAGAACTACAGGCTTATC TTACAGCTGTTTGTGGGCTTGGCCGTCGGGACACTGTCTGGGGACGCTCTGCTCCACCTT ATCCCTCAGGTTCTTGGTTTACATAAGCAGGAAGCCCCAGAATTTGGGCATTTCCATGAA AGCAAAGGTCATATTTGGAAACTGATGGGATTAATTGGAGGCATCCATGGATTTTTCTTG ATAGAAAAATGTTTTATTCTTCTTGTATCACCAAATGACAAGCAGGGCCTGTCATTGGTT AATGGGCACGTGGGTCATTCCCACCATCTTGCACTCAACTCTGAATTAAGTGACCAGGCA GGCAGAGGCAAATCTGCTTCAACTATCCAGTTGAAAAGCCCAGAAGATTCACAGGCAGCT GAAATGCCTATAGGCAGTATGACAGCCTCCAACAGAAAATGTAAAGCCATTAGCTTGTTA GCAATCATGATTCTGGTTGGGGACAGCCTGCATAATTTTGCAGATGGCCTAGCCATAGGA GCAGCCTTCTCATCATCATCCGAGTCAGGAGTGACCACTACGATTGCTATCTTGTGTCAT GAAATCCCACATGAAATGGGAGACTTTGCCGTGCTCTTAAGCTCTGGACTTTCTATGAAG ACTGCCATCCTGATGAATTTTATAAGCTCCCTAACTGCCTTCATGGGATTATACATTGGC CTTTCCGTGTCAGCTGATCCATGTGTTCAAGACTGGATCTTCACAGTCACTGCTGGGATG TTCTTATATTTATCCTTGGTTGAAATGCTTCCTGAAATGACTCATGTTCAAACACAACGA CCCTGGATGATGTTTCTCCTGCAAAACTTTGGATTGATCCTAGGTTGGCTTTCTCTCCTG CTCTTGGCTATATATGAGCAAAATATTAAAATATAA
- Chromosome Location
- 10
- Locus
- 10p12.33
- External Identifiers
Resource Link UniProtKB ID Q504Y0 UniProtKB Entry Name S39AC_HUMAN HGNC ID HGNC:20860 - General References
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