Choline transporter-like protein 4
Details
- Name
- Choline transporter-like protein 4
- Synonyms
- C6orf29
- CTL4
- hTPPT1
- NG22
- Solute carrier family 44 member 4
- Thiamine pyrophosphate transporter 1
- TPPT1
- Gene Name
- SLC44A4
- UniProtKB Entry
- Q53GD3Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037172|Choline transporter-like protein 4 MGGKQRDEDDEAYGKPVKYDPSFRGPIKNRSCTDVICCVLFLLFILGYIVVGIVAWLYGD PRQVLYPRNSTGAYCGMGENKDKPYLLYFNIFSCILSSNIISVAENGLQCPTPQVCVSSC PEDPWTVGKNEFSQTVGEVFYTKNRNFCLPGVPWNMTVITSLQQELCPSFLLPSAPALGR CFPWTNVTPPALPGITNDTTIQQGISGLIDSLNARDISVKIFEDFAQSWYWILVALGVAL VLSLLFILLLRLVAGPLVLVLILGVLGVLAYGIYYCWEEYRVLRDKGASISQLGFTTNLS AYQSVQETWLAALIVLAVLEAILLLMLIFLRQRIRIAIALLKEASKAVGQMMSTMFYPLV TFVLLLICIAYWAMTALYLATSGQPQYVLWASNISSPGCEKVPINTSCNPTAHLVNSSCP GLMCVFQGYSSKGLIQRSVFNLQIYGVLGLFWTLNWVLALGQCVLAGAFASFYWAFHKPQ DIPTFPLISAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQNPVARCIMCC FKCCLWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVRVVVLDKVTDLLLF FGKLLVVGGVGVLSFFFFSGRIPGLGKDFKSPHLNYYWLPIMTSILGAYVIASGFFSVFG MCVDTLFLCFLEDLERNNGSLDRPYYMSKSLLKILGKKNEAPPDNKKRKK
- Number of residues
- 710
- Molecular Weight
- 79252.975
- Theoretical pI
- 8.67
- GO Classification
- Functionsantiporter activity / choline transmembrane transporter activity / thiamine pyrophosphate transmembrane transporter activityProcessescholine transport / neuromast hair cell development / otolith formation / thiamine pyrophosphate transmembrane transportComponentsapical plasma membrane
- General Function
- Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411, PubMed:26741288)
- Specific Function
- antiporter activity
- Pfam Domain Function
- Choline_transpo (PF04515)
- Signal Regions
- Not Available
- Transmembrane Regions
- 35-55 230-250 253-273 310-330 359-379 456-476 502-522 561-581 598-618 639-659
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0011576|Choline transporter-like protein 4 (SLC44A4) ATGGGGGGAAAGCAGCGGGACGAGGATGACGAGGCCTACGGGAAGCCAGTCAAATACGAC CCCTCCTTTCGAGGCCCCATCAAGAACAGAAGCTGCACAGATGTCATCTGCTGCGTCCTC TTCCTGCTCTTCATTCTAGGTTACATCGTGGTGGGGATTGTGGCCTGGTTGTATGGAGAC CCCCGGCAAGTCCTCTACCCCAGGAACTCTACTGGGGCCTACTGTGGCATGGGGGAGAAC AAAGATAAGCCGTATCTCCTGTACTTCAACATCTTCAGCTGCATCCTGTCCAGCAACATC ATCTCAGTTGCTGAGAACGGCCTACAGTGCCCCACACCCCAGACGGTGATCACAAGCCTG CAACAGGAACTCTGCCCCAGTTTCCTCCTCCCCTCTGCTCCAGCTCTGGGGCGCTGCTTT CCATGGACCAACGTTACTCCACCGGCGCTCCCAGGGATCACCAATGACACCACCATACAG CAGGGGATCAGCGGTCTTATTGACAGCCTCAATGCCCGAGACATCAGTGTTAAGATCTTT GAAGATTTTGCCCAGTCCTGGTATTGGATTCTTGTTGCCCTGGGGGTGGCTCTGGTCTTG AGCCTACTGTTTATCTTGCTTCTGCGCCTGGTGGCTGGGCCCCTGGTGCTGGTGCTGATC CTGGGAGTGCTGGGCGTGCTGGCATACGGCATCTACTACTGCTGGGAGGAGTACCGAGTG CTGCGGGACAAGGGCGCCTCCATCTCCCAGCTGGGTTTCACCACCAACCTCAGTGCCTAC CAGAGCGTGCAGGAGACCTGGCTGGCCGCCCTGATCGTGTTGGCGGTGCTTGAAGCCATC CTGCTGCTGATGCTCATCTTCCTGCGGCAGCGGATTCGTATTGCCATCGCCCTCCTGAAG GAGGCCAGCAAGGCTGTGGGACAGATGATGTCTACCATGTTCTACCCACTGGTCACCTTT GTCCTCCTCCTCATCTGCATTGCCTACTGGGCCATGACTGCTCTGTACCTGGCTACATCG GGGCAACCCCAGTATGTGCTCTGGGCATCCAACATCAGCTCCCCCGGCTGTGAGAAAGTG CCAATAAATACATCATGCAACCCCACGGCCCACCTTGTGAACTCCTCGTGCCCAGGGCTG ATGTGCGTCTTCCAGGGCTACTCATCCAAAGGCCTAATCCAACGTTCTGTCTTCAATCTG CAAATCTATGGGGTCCTGGGGCTCTTCTGGACCCTTAACTGGGTACTGGCCCTGGGCCAA TGCGTCCTCGCTGGAGCCTTTGCCTCCTTCTACTGGGCCTTCCACAAGCCCCAGGACATC CCTACCTTCCCCTTAATCTCTGCCTTCATCCGCACACTCCGTTACCACACTGGGTCATTG GCATTTGGAGCCCTCATCCTGACCCTTGTGCAGATAGCCCGGGTCATCTTGGAGTATATT GACCACAAGCTCAGAGGAGTGCAGAACCCTGTAGCCCGCTGCATCATGTGCTGTTTCAAG TGCTGCCTCTGGTGTCTGGAAAAATTTATCAAGTTCCTAAACCGCAATGCATACATCATG ATCGCCATCTACGGGAAGAATTTCTGTGTCTCAGCCAAAAATGCGTTCATGCTACTCATG CGAAACATTGTCAGGGTGGTCGTCCTGGACAAAGTCACAGACCTGCTGCTGTTCTTTGGG AAGCTGCTGGTGGTCGGAGGCGTGGGGGTCCTGTCCTTCTTTTTTTTCTCCGGTCGCATC CCGGGGCTGGGTAAAGACTTTAAGAGCCCCCACCTCAACTATTACTGGCTGCCCATCATG ACCTCCATCCTGGGGGCCTATGTCATCGCCAGCGGCTTCTTCAGCGTTTTCGGCATGTGT GTGGACACGCTCTTCCTCTGCTTCCTGGAAGACCTGGAGCGGAACAACGGCTCCCTGGAC CGGCCCTACTACATGTCCAAGAGCCTTCTAAAGATTCTGGGCAAGAAGAACGAGGCGCCC CCGGACAACAAGAAGAGGAAGAAGTGA
- Chromosome Location
- 6
- Locus
- 6p21.33
- External Identifiers
Resource Link UniProtKB ID Q53GD3 UniProtKB Entry Name CTL4_HUMAN GenBank Protein ID 14042044 GenBank Gene ID AK027397 GeneCard ID SLC44A4 GenAtlas ID SLC44A4 HGNC ID HGNC:13941 KEGG ID hsa:80736 NCBI Gene ID 80736 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Choline transporter-like protein 4 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Choline approved, nutraceutical unknown transporter substrate Details Choline salicylate approved, nutraceutical unknown transporter substrate Details