Diacylglycerol O-acyltransferase 2
Details
- Name
- Diacylglycerol O-acyltransferase 2
- Synonyms
- 2.3.1.20
- Acyl-CoA retinol O-fatty-acyltransferase
- ARAT
- Diglyceride acyltransferase 2
- Retinol O-fatty-acyltransferase
- Gene Name
- DGAT2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049585|Diacylglycerol O-acyltransferase 2 MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT MYMEALVKLFDKHKTKFGLPETEVLEVN
- Number of residues
- 388
- Molecular Weight
- 43830.475
- Theoretical pI
- Not Available
- GO Classification
- Functions2-acylglycerol O-acyltransferase activity / diacylglycerol O-acyltransferase activity / protein homodimerization activity / retinol O-fatty-acyltransferase activityProcessesacylglycerol acyl-chain remodeling / cellular response to oleic acid / cellular triglyceride homeostasis / cholesterol homeostasis / diacylglycerol metabolic process / fat pad development / fatty acid homeostasis / glycerol metabolic process / lipid storage / long-chain fatty-acyl-CoA metabolic process / low-density lipoprotein particle clearance / negative regulation of fatty acid oxidation / positive regulation of gluconeogenesis / positive regulation of triglyceride biosynthetic process / regulation of cholesterol metabolic process / regulation of lipoprotein metabolic process / regulation of plasma lipoprotein particle levels / triglyceride biosynthetic processComponentsendoplasmic reticulum / endoplasmic reticulum membrane / integral component of endoplasmic reticulum membrane / integral component of membrane / lipid particle / mitochondrion / perinuclear region of cytoplasm
- General Function
- Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).
- Specific Function
- 2-acylglycerol o-acyltransferase activity
- Pfam Domain Function
- DAGAT (PF03982)
- Transmembrane Regions
- 70-88 93-112
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0049586|Diacylglycerol O-acyltransferase 2 (DGAT2) ATGAAGACCCTCATAGCCGCCTACTCCGGGGTCCTGCGCGGCGAGCGTCAGGCCGAGGCT GACCGGAGCCAGCGCTCTCACGGAGGACCTGCGCTGTCGCGCGAGGGGTCTGGGAGATGG GGCACTGGATCCAGCATCCTCTCCGCCCTCCAGGACCTCTTCTCTGTCACCTGGCTCAAT AGGTCCAAGGTGGAAAAGCAGCTACAGGTCATCTCAGTGCTCCAGTGGGTCCTGTCCTTC CTTGTACTGGGAGTGGCCTGCAGTGCCATCCTCATGTACATATTCTGCACTGATTGCTGG CTCATCGCTGTGCTCTACTTCACTTGGCTGGTGTTTGACTGGAACACACCCAAGAAAGGT GGCAGGAGGTCACAGTGGGTCCGAAACTGGGCTGTGTGGCGCTACTTTCGAGACTACTTT CCCATCCAGCTGGTGAAGACACACAACCTGCTGACCACCAGGAACTATATCTTTGGATAC CACCCCCATGGTATCATGGGCCTGGGTGCCTTCTGCAACTTCAGCACAGAGGCCACAGAA GTGAGCAAGAAGTTCCCAGGCATACGGCCTTACCTGGCTACACTGGCAGGCAACTTCCGA ATGCCTGTGTTGAGGGAGTACCTGATGTCTGGAGGTATCTGCCCTGTCAGCCGGGACACC ATAGACTATTTGCTTTCAAAGAATGGGAGTGGCAATGCTATCATCATCGTGGTCGGGGGT GCGGCTGAGTCTCTGAGCTCCATGCCTGGCAAGAATGCAGTCACCCTGCGGAACCGCAAG GGCTTTGTGAAACTGGCCCTGCGTCATGGAGCTGACCTGGTTCCCATCTACTCCTTTGGA GAGAATGAAGTGTACAAGCAGGTGATCTTCGAGGAGGGCTCCTGGGGCCGATGGGTCCAG AAGAAGTTCCAGAAATACATTGGTTTCGCCCCATGCATCTTCCATGGTCGAGGCCTCTTC TCCTCCGACACCTGGGGGCTGGTGCCCTACTCCAAGCCCATCACCACTGTTGTGGGAGAG CCCATCACCATCCCCAAGCTGGAGCACCCAACCCAGCAAGACATCGACCTGTACCACACC ATGTACATGGAGGCCCTGGTGAAGCTCTTCGACAAGCACAAGACCAAGTTCGGCCTCCCG GAGACTGAGGTCCTGGAGGTGAACTGA
- Chromosome Location
- 11
- Locus
- 11q13.5
- External Identifiers
Resource Link UniProtKB ID Q96PD7 UniProtKB Entry Name DGAT2_HUMAN HGNC ID HGNC:16940 - General References
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- Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y: A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice. Biochem Biophys Res Commun. 2003 Oct 17;310(2):296-302. [Article]
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- Orland MD, Anwar K, Cromley D, Chu CH, Chen L, Billheimer JT, Hussain MM, Cheng D: Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. Biochim Biophys Acta. 2005 Oct 15;1737(1):76-82. Epub 2005 Sep 20. [Article]
- Hong YB, Kang J, Kim JH, Lee J, Kwak G, Hyun YS, Nam SH, Hong HD, Choi YR, Jung SC, Koo H, Lee JE, Choi BO, Chung KW: DGAT2 Mutation in a Family with Autosomal-Dominant Early-Onset Axonal Charcot-Marie-Tooth Disease. Hum Mutat. 2016 May;37(5):473-80. doi: 10.1002/humu.22959. Epub 2016 Feb 9. [Article]