Human chromosome 11 DNA sequence and analysis including novel gene identification.
Article Details
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Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Nature. 2006 Mar 23;440(7083):497-500.
- PubMed ID
- 16554811 [ View in PubMed]
- Abstract
Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here--nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence--provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial P10515 Details B-lymphocyte antigen CD20 P11836 Details Acetyl-CoA acetyltransferase, mitochondrial P24752 Details Muscarinic acetylcholine receptor M1 P11229 Details NADH dehydrogenase [ubiquinone] 1 subunit C2 O95298 Details NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial O75489 Details Aldehyde dehydrogenase family 3 member B2 P48448 Details ATP-binding cassette sub-family C member 8 Q09428 Details Transcobalamin-1 P20061 Details 5-hydroxytryptamine receptor 3A P46098 Details NADP-dependent malic enzyme, mitochondrial Q16798 Details D(4) dopamine receptor P21917 Details L-lactate dehydrogenase A chain P00338 Details Caspase-1 P29466 Details Progesterone receptor P06401 Details Glutamate carboxypeptidase 2 Q04609 Details Isobutyryl-CoA dehydrogenase, mitochondrial Q9UKU7 Details Tyrosine 3-monooxygenase P07101 Details Folate receptor gamma P41439 Details Potassium voltage-gated channel subfamily KQT member 1 P51787 Details Pyruvate carboxylase, mitochondrial P11498 Details Cysteine--tRNA ligase, cytoplasmic P49589 Details ATP-sensitive inward rectifier potassium channel 11 Q14654 Details DNA polymerase alpha subunit B Q14181 Details Choline kinase alpha P35790 Details Glutamate receptor 4 P48058 Details Solute carrier family 22 member 11 Q9NSA0 Details Excitatory amino acid transporter 2 P43004 Details Fatty acid desaturase 1 O60427 Details Peroxiredoxin-5, mitochondrial P30044 Details Glycogen phosphorylase, muscle form P11217 Details Sphingomyelin phosphodiesterase P17405 Details Beta-secretase 1 P56817 Details Solute carrier organic anion transporter family member 2B1 O94956 Details Solute carrier family 22 member 6 Q4U2R8 Details Calcitonin gene-related peptide 1 P06881 Details CD44 antigen P16070 Details Metabotropic glutamate receptor 5 P41594 Details Catalase P04040 Details cGMP-inhibited 3',5'-cyclic phosphodiesterase B Q13370 Details Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 O94766 Details cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 Details Bone marrow proteoglycan P13727 Details Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 Q96Q83 Details G protein-activated inward rectifier potassium channel 4 P48544 Details Glutamine-dependent NAD(+) synthetase Q6IA69 Details Fatty acid desaturase 2 O95864 Details Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial O14521 Details Mitochondrial glutamate carrier 1 Q9H936 Details Glycine N-acyltransferase Q6IB77 Details Glycine N-acyltransferase-like protein 1 Q969I3 Details Sodium- and chloride-dependent glycine transporter 2 Q9Y345 Details Probable asparagine--tRNA ligase, mitochondrial Q96I59 Details P2Y purinoceptor 2 P41231 Details Plasma protease C1 inhibitor P05155 Details Oxidoreductase HTATIP2 Q9BUP3 Details N-terminal kinase-like protein Q96KG9 Details Wee1-like protein kinase P30291 Details Serine/threonine-protein kinase Chk1 O14757 Details Brain-derived neurotrophic factor P23560 Details T-cell surface glycoprotein CD3 delta chain P04234 Details 1-aminocyclopropane-1-carboxylate synthase-like protein 1 Q96QU6 Details Prostaglandin D2 receptor 2 Q9Y5Y4 Details Guanylate cyclase soluble subunit alpha-2 P33402 Details Sodium channel subunit beta-4 Q8IWT1 Details Solute carrier family 22 member 8 Q8TCC7 Details Solute carrier family 22 member 10 Q63ZE4 Details Matrix metalloproteinase-20 O60882 Details Matrix metalloproteinase-27 Q9H306 Details Pannexin-1 Q96RD7 Details Steroid hormone receptor ERR1 P11474 Details Oxysterols receptor LXR-alpha Q13133 Details Inner centromere protein Q9NQS7 Details Serine/threonine-protein phosphatase PP1-alpha catalytic subunit P62136 Details Trafficking protein particle complex subunit 4 Q9Y296 Details Protein arginine N-methyltransferase 3 O60678 Details Potassium voltage-gated channel subfamily A member 4 P22459 Details Radixin P35241 Details NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 Details Histone acetyltransferase KAT5 Q92993 Details Gastric intrinsic factor P27352 Details Neutral alpha-glucosidase AB Q14697 Details Equilibrative nucleoside transporter 2 Q14542 Details Potassium voltage-gated channel subfamily C member 1 P48547 Details Solute carrier family 22 member 12 Q96S37 Details Serum amyloid A-1 protein P0DJI8 Details Serine-protein kinase ATM Q13315 Details Layilin Q6UX15 Details Hephaestin-like protein 1 Q6MZM0 Details Nucleobindin-2 P80303 Details Cation channel sperm-associated protein 1 Q8NEC5 Details Diacylglycerol O-acyltransferase 2 Q96PD7 Details Stress-induced-phosphoprotein 1 P31948 Details Protein RIC-3 Q7Z5B4 Details Flap endonuclease 1 P39748 Details Apolipoprotein A-IV P06727 Details Amyloid-like protein 2 Q06481 Details Splicing factor 1 Q15637 Details Sn1-specific diacylglycerol lipase alpha F5GY58 Details Serine/threonine-protein kinase MRCK gamma Q6DT37 Details Homeodomain-interacting protein kinase 3 Q9H422 Details Serine/threonine-protein kinase SIK3 Q9Y2K2 Details Mitogen-activated protein kinase kinase kinase 11 Q16584 Details Mitogen-activated protein kinase kinase kinase kinase 2 Q12851 Details Serine/threonine-protein kinase MARK2 Q7KZI7 Details Serine/threonine-protein kinase PAK 1 Q13153 Details ADP-ribosylation factor-like protein 2 P36404 Details Pepsin A-5 P0DJD9 Details Solute carrier family 43 member 3 Q8NBI5 Details P2X purinoceptor 3 P56373 Details Zinc transporter ZIP13 Q96H72 Details Diacylglycerol kinase zeta Q13574 Details Caspase-4 P49662 Details