Microsomal glutathione S-transferase 2
Details
- Name
- Microsomal glutathione S-transferase 2
- Synonyms
- 2.5.1.18
- GST2
- Microsomal GST-2
- Microsomal GST-II
- Gene Name
- MGST2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004496|Microsomal glutathione S-transferase 2 MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL LGALGIANSFLDEYLDLNIAKKLRRQF
- Number of residues
- 147
- Molecular Weight
- 16620.4
- Theoretical pI
- 9.88
- GO Classification
- Functionsenzyme activator activity / glutathione peroxidase activity / glutathione transferase activity / leukotriene-C4 synthase activityProcessesglutathione biosynthetic process / glutathione derivative biosynthetic process / leukotriene biosynthetic process / oxidation-reduction process / small molecule metabolic process / xenobiotic metabolic processComponentsendoplasmic reticulum membrane / integral component of membrane / intracellular membrane-bounded organelle / nuclear envelope / plasma membrane
- General Function
- Leukotriene-c4 synthase activity
- Specific Function
- Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.
- Pfam Domain Function
- MAPEG (PF01124)
- Transmembrane Regions
- 6-26 59-79 111-131
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0016743|Microsomal glutathione S-transferase 2 (MGST2) ATGGCCGGGAACTCGATCCTGCTGGCTGCTGTCTCTATTCTCTCGGCCTGTCAGCAAAGT TATTTTGCTTTGCAAGTTGGAAAGGCAAGATTAAAATACAAAGTTACGCCCCCAGCAGTC ACTGGGTCACCAGAGTTTGAGAGAGTATTTCGGGCACAACAAAACTGTGTGGAGTTTTAT CCTATATTCATAATTACATTGTGGATGGCTGGGTGGTATTTCAACCAAGTTTTTGCTACT TGTCTGGGTCTGGTGTACATATATGGCCGTCACCTATACTTCTGGGGATATTCAGAAGCT GCTAAAAAACGGATCACCGGTTTCCGACTGAGTCTGGGGATTTTGGCCTTGTTGACCCTC CTAGGTGCCCTGGGAATTGCAAACAGCTTTCTGGATGAATATCTGGACCTCAATATTGCC AAGAAACTGAGGCGGCAATTCTAA
- Chromosome Location
- 4
- Locus
- 4q28.3
- External Identifiers
Resource Link UniProtKB ID Q99735 UniProtKB Entry Name MGST2_HUMAN GenBank Protein ID 1747521 GenBank Gene ID U77604 GenAtlas ID MGST2 HGNC ID HGNC:7063 - General References
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