Reaction: Zolpidem to 1 product
- Reaction
- Reaction type
- methyl-hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Pichard L, Gillet G, Bonfils C, Domergue J, Thenot JP, Maurel P: Oxidative metabolism of zolpidem by human liver cytochrome P450S. Drug Metab Dispos. 1995 Nov;23(11):1253-62. [Article]
- Reidy L, Nolan B, Ramos AR, Walls HC, Steele BW: Zolpidem urine excretion profiles and cross-reactivity with ELISA((R)) kits in subjects using Zolpidem or Ambien((R)) CR as a prescription sleep aid. J Anal Toxicol. 2011 Jun;35(5):294-301. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2C9 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available confirmed Cytochrome P450 3A4 Not Available Not Available confirmed Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 2D6 Not Available Not Available confirmed