Reaction: Sertraline to 1 product

Reaction
Sertraline
DB01104
norsertraline
DBMET00335
Reaction type
N-demethylation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Fishback JA, Robson MJ, Xu YT, Matsumoto RR: Sigma receptors: potential targets for a new class of antidepressant drug. Pharmacol Ther. 2010 Sep;127(3):271-82. doi: 10.1016/j.pharmthera.2010.04.003. Epub 2010 May 11. [Article]
  2. Sproule BA, Otton SV, Cheung SW, Zhong XH, Romach MK, Sellers EM: CYP2D6 inhibition in patients treated with sertraline. J Clin Psychopharmacol. 1997 Apr;17(2):102-6. doi: 10.1097/00004714-199704000-00007. [Article]
  3. Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. Epub 2004 Nov 16. [Article]
  4. FDA Approved Drug Products: Zoloft (sertraline hydrochloride) for oral use [Link]
  5. Sertraline pathway [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 2D6Not AvailableNot Availableconfirmed
Cytochrome P450 2C9Not AvailableNot Availableconfirmed
Cytochrome P450 2C19Not AvailableNot Availableconfirmed
Cytochrome P450 2B6Not AvailableNot Availableconfirmed