Reaction: Isosorbide mononitrate to 1 product
Major circulating metaboliteMetabolism of Isosorbide mononitrate
Isosorbide mononitrate is converted to Nitric Oxide by Cytochrome P450 3A Subfamily, Glutathione S-transferase Mu 1, Xanthine dehydrogenase/oxidase and 1 other enzyme.
- Reaction
- Direction
- Activity
- active
- Comments
- Based on the findings of several studies, isosorbide mononitrate is bioactivated by hepatic CYP P450 enzymes, xanthine oxidoreductase (XO), mu isozyme of glutathione-S-transferase (GST), or cytosolic aldehyde dehydrogenase isoforms (cytALDH = 1A1, 3A1 or cytosolic ALDH-2).[A190732]
What you can answer from here — as of February 11, 2020
4EnzymesEach linked to its target cardListed above
Which other drugs are metabolised by Cytochrome P450 3A Subfamily, Glutathione S-transferase Mu 1, and Xanthine dehydrogenase/oxidase, and which of those pairings are clinically significant?
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