Reaction: Doxorubicin to 1 product

Reaction
Reaction type
Not Available
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
  2. Kassner N, Huse K, Martin HJ, Godtel-Armbrust U, Metzger A, Meineke I, Brockmoller J, Klein K, Zanger UM, Maser E, Wojnowski L: Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab Dispos. 2008 Oct;36(10):2113-20. doi: 10.1124/dmd.108.022251. Epub 2008 Jul 17. [Article]
  3. Mordente A, Minotti G, Martorana GE, Silvestrini A, Giardina B, Meucci E: Anthracycline secondary alcohol metabolite formation in human or rabbit heart: biochemical aspects and pharmacologic implications. Biochem Pharmacol. 2003 Sep 15;66(6):989-98. doi: 10.1016/s0006-2952(03)00442-8. [Article]
  4. Mordente A, Meucci E, Silvestrini A, Martorana GE, Giardina B: New developments in anthracycline-induced cardiotoxicity. Curr Med Chem. 2009;16(13):1656-72. [Article]
  5. Bains OS, Karkling MJ, Lubieniecka JM, Grigliatti TA, Reid RE, Riggs KW: Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. J Pharmacol Exp Ther. 2010 Mar;332(3):755-63. doi: 10.1124/jpet.109.160614. Epub 2009 Dec 9. [Article]
  6. Novotna R, Wsol V, Xiong G, Maser E: Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3. Toxicol Lett. 2008 Sep;181(1):1-6. doi: 10.1016/j.toxlet.2008.06.858. Epub 2008 Jun 21. [Article]
  7. Reis-Mendes A, Carvalho F, Remiao F, Sousa E, Bastos ML, Costa VM: The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells. Biomolecules. 2019 Mar 11;9(3):98. doi: 10.3390/biom9030098. [Article]
  8. Choi WG, Kim DK, Shin Y, Park R, Cho YY, Lee JY, Kang HC, Lee HS: Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Determination of Doxorubicin and its Metabolites Doxorubicinol, Doxorubicinone, Doxorubicinolone, and 7-Deoxydoxorubicinone in Mouse Plasma. Molecules. 2020 Mar 10;25(5):1254. doi: 10.3390/molecules25051254. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Carbonyl reductase [NADPH] 1Not AvailableNot Availableconfirmed
Carbonyl reductase [NADPH] 3Not AvailableNot Availableconfirmed
Aldo-keto reductase family 1 member C3Not AvailableNot Availableconfirmed
Alcohol dehydrogenase [NADP(+)]Not AvailableNot Availableconfirmed