Carbonyl reductase [NADPH] 1

BE0003074ProteinHumansCBR1

NADPH-dependent reductase with broad substrate specificity. It is acted on by 25 drugs in DrugBank.

Gene name
CBR1
UniProtKB entry
P16152Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
277 residues · 30,375 Da
Also known as
1.1.1.184 · 15-hydroxyprostaglandin dehydrogenase [NADP(+)] · 20-beta-hydroxysteroid dehydrogenase · Alcohol dehydrogenase [NAD(P)+] CBR1 · CBR

Resolves to

Protein
UniProtP16152UniProt nameCBR1_HUMAN
Gene
HGNCHGNC:1548NCBI Gene873GeneCardsCBR1
Pharmacology
IUPHAR/GtoPdb1383KEGGhsa:873
Structure
PDB1WMAPDB2PFGPDB3BHI
Drugs

What you can answer from here — as of September 07, 2019

25DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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9Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbonyl reductase [NADPH] 1, how selective are they, and which programs against it are still in active trials?

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