Reaction: Ponesimod to 1 product

Reaction
Ponesimod
DB12016
Ponesimod M12 Metabolite (ACT-204426)
DBMET03311
Reaction type
oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Reyes M, Hoch M, Brossard P, Wagner-Redeker W, Miraval T, Dingemanse J: Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans. Xenobiotica. 2015 Feb;45(2):139-49. doi: 10.3109/00498254.2014.955832. Epub 2014 Sep 4. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2J2Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 3A5Not AvailableNot Availableconfirmed
Cytochrome P450 4F3Not AvailableNot Availableconfirmed
Cytochrome P450 4F12Not AvailableNot Availableconfirmed