Cytochrome P450 2J2

BE0003683ProteinHumansCYP2J2

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:19965576, PubMed:8631948). It is acted on by 28 drugs in DrugBank.

Gene name
CYP2J2
UniProtKB entry
P51589Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
502 residues · 57,610 Da
Also known as
1.14.14.- · Albendazole monooxygenase (hydroxylating) · Albendazole monooxygenase (sulfoxide-forming) · Arachidonic acid epoxygenase · CYPIIJ2

Resolves to

Protein
UniProtP51589UniProt nameCP2J2_HUMAN
Gene
HGNCHGNC:2634NCBI Gene1573GenBank18254513GeneCardsCYP2J2
Pharmacology
IUPHAR/GtoPdb1332KEGGhsa:1573
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
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7Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2J2, how selective are they, and which programs against it are still in active trials?

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