Reaction: Macitentan to 1 product

dealkylationMajor circulating metaboliteMetabolism of Macitentan

Macitentan is converted to M6 by Cytochrome P450 3A4, Cytochrome P450 2C8, Cytochrome P450 2C9 and 1 other enzyme.

Direction
Activity
active

What you can answer from here — as of November 24, 2021

4EnzymesEach linked to its target card
Listed above
2ReferencesThe literature this reaction is curated from
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Which other drugs are metabolised by Cytochrome P450 3A4, Cytochrome P450 2C8, and Cytochrome P450 2C9, and which of those pairings are clinically significant?

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