Reaction: Imatinib to 1 product
- Reaction
- Reaction type
- N-oxidation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Rochat B, Zoete V, Grosdidier A, von Grunigen S, Marull M, Michielin O: In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1. Biopharm Drug Dispos. 2008 Mar;29(2):103-18. doi: 10.1002/bdd.598. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 1A1 Not Available Not Available confirmed Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 1B1 Not Available Not Available confirmed Cytochrome P450 3A4 Not Available Not Available confirmed