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Lysophosphatidic Acid LPA5 Signalling
smpdb.ca/view/SMP0063757SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasCyclophosphamide Action Pathway
smpdb.ca/view/SMP0000447Drug actionCyclophosphamide is an alkylating agent used in the treatment of certain cancers. Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide i...
Enzymes: Glutathione S-transferase Mu 1Dienogest Action Pathway
smpdb.ca/view/SMP0126541Drug actionDienogest is a semisynthetic progestogen derived from 19-nortestosterone and has antiandrogenic properties. This drug is used as a contraceptive or to treat endometriosis alone or combined with ethinylestradiol. Dienogest acts by binding...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Drospirenone Action Pathway
smpdb.ca/view/SMP0126538Drug actionDrospirenone is a synthetic progestin commonly found in popular oral contraceptives like Yaz, Angeliq, and Loryna. This drug is also indicated to control acne, menopause-associated symptoms, and premenstrual dysphoric disorder (PMDD) whe...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Gq Muscarinic Smooth Muscle Contraction
smpdb.ca/view/SMP0126945PhysiologicalGq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be refer...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGq Histaminic Smooth Muscle Contraction
smpdb.ca/view/SMP0126962PhysiologicalThe H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine. It is expressed in smooth muscles, on vascular endothelial cells, ...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortLysophosphatidic Acid LPA4 Signalling
smpdb.ca/view/SMP0063756SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasAcetaminophen Metabolism Pathway
smpdb.ca/view/SMP0000640Drug metabolismAcetaminophen (APAP) is metabolized primarily in the liver. Glucuronidation is the main route, accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut. APAP can al...
Enzymes: Glutathione S-transferase P, Glutathione S-transferase theta-1Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126568Drug actionDipivefrin is a prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologi...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Esketamine Action Pathway
smpdb.ca/view/SMP0126267Drug actionIt is nasal sprayand the s-enantiomer of Ketamine.