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Fentanyl Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125203Drug actionFentanyl is a potent opioid agonistused for strong and rapid analgesia. It is used to treat strong cancer pain or in anesthesia. It is regularly injected intravenously or intramuscularly or it can be taken orally as a tablet. It is commo...
Drugs: ATP · Fentanyl · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Morphine Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125018Drug actionMorphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. Morphine can be administered orally as a capsule or tablet, intravenously, intrathecally, or as an epidural. Morphine-6-glucuronide, a metabo...
Drugs: ATP · Morphine · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Dihydromorphine Opioid Agonist Action Pathway
smpdb.ca/view/SMP0124999Drug actionDihydromorphine is a semisynthetic opioid analgesic. Dihydromorphine binds on pre-synaptic mu opioid receptors. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic trans...
Drugs: ATP · Calcium · Magnesium cation · Dihydromorphine · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Carfentanil Opioid Agonist Action Pathway
smpdb.ca/view/SMP0125010Drug actionCarfentanil is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known. It is used as a tranquilizer for large animals. Carfentanil acts primarily on the mu (some kappa and delta) opioi...
Drugs: ATP · Calcium · Magnesium cation · Carfentanil · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Ketobemidone Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126793Drug actionKetobemidone is a powerful opioid analgesic with some NMDA-antagonist properties. Ketobemidone is an agonist of mu, kappa, and delta opioid receptors. Mu-binding sites are discretely distributed in the brain, spinal cord, and other tissu...
Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Etorphine Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126797Drug actionEtorphine is a narcotic analgesic used as a sedative in veterinary practice. It is a synthetic cousin of morphine, and it is 40,000 times more powerful than morphine. Etorphine binds to mu, delta, and kappa opioid receptors, stimulating ...
Drugs: ATP · Calcium · Magnesium cation · Etorphine · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Lofentanil Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126798Drug actionLofentanil is an analog of fentanyl and a potent opioid. Lofentanil binds to opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner su...
Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Bezitramide Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126801Drug actionBezitramide is a narcotic analgesic that has been withdrawn due to overdoses. It is taken orally with a long duration of action. Bezitramide binds to opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As ...
Drugs: ATP · Calcium · Magnesium cation · Bezitramide · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Oliceridine Opioid Agonist Action Pathway
smpdb.ca/view/SMP0126824Drug actionOliceridine is a biased mu-opioid agonist indicated for the management of severe pain by blocking nociceptive signalling. Oliceridine binds to mu opioid receptors on presynaptic neuron membranes, stimulating the exchange of GTP for GDP o...
Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2Methadone Opioid Agonist Action Pathway
smpdb.ca/view/SMP0124670Drug actionMethadone is a synthetic mu-opioid receptor agonst as well as a N-methyl-d-aspartate (NMDA) receptor antagonist. As a mu opioid receptor agonist it exerts similar qualities to other opioids like morphine and heroin by decreasing GABA rel...
Drugs: ATP · Methadone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2