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Promazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126483Drug actionPromazine is used as an adjunct for short term treatment of moderate and severe psychomotor agitation. It is also used to treat agitation or restlessness in the elderly. Promazine is an antagonist at types 1, 2, and 4 dopamine receptors,...
Droperidol Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126486Drug actionDroperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2...
Fluspirilene Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126514Drug actionFluspirilene is an antipsychotic agent used in the treatment of schizophrenia. Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia. Fluspirilene does not differ greatly from other depot ant...
Flupentixol Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126515Drug actionFlupentixol is a first generation antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in i...
Pimozide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126532Drug actionPimozide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluoropheny...
Thioridazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126559Drug actionThioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal...
Trifluoperazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126561Drug actionTrifluoperazine is a trifluoro-methyl phenothiazine derivative. Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed ...
Methotrimeprazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126562Drug actionMethotrimeprazine is a phenothiazine derivative, a first-generation antipsychotic, dopamine receptor antagonists (DRA) and a typical antipsychotic. Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine rec...
Acepromazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126576Drug actionAcepromazine is a phenothiazine tranquilizer that blocks dopamine receptors in the CNS and depresses the reticular-activating system, resulting in sedation. Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It...
Thiothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126580Drug actionThiothixene is an antipsychotic of the thioxanthene series. Thiothixene acts as an antagonist (blocking agent) on different post-sysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic propert...