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Displaying results 91 - 100 of 1076 in total
  1. Drug

    Tomaralimab

    go.drugbank.com/drugs/DB15415
    Investigational

    Tomaralimab is under investigation in clinical trial NCT01794663 (Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function).

    Synonyms: Humanized IGG4 monoclonal antibody against toll-like receptor 2 for prevention of ischemia/reperfusion tissue injury
  2. Drug

    Etevritamab

    go.drugbank.com/drugs/DB17211
    Investigational

    Synonyms: IMMUNOGLOBULIN SCFV-SCFV, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB) VARIANT III (EGFRVIII)) AND ANTI-(HOMO SAPIENS CD3E, IMMUNOGLOBULIN, BISPECIFIC, ANTI-(HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III) (HUMAN MONOCLONAL EGFRVIII BISPECIFIC 1 SINGLE-CHAIN VARIABLE FRAGMENT VH1-(GGGGS)3-VL1) FUSION PROTEIN WITH PEPTIDE
  3. Pathway

    Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

    smpdb.ca/view/SMP0000320
    Signaling

    The A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. … The A2A receptor is responsible for regulating myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension.

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Adenosine receptor A2a
  4. Pathway

    Intracellular Signalling Through Histamine H2 Receptor and Histamine

    smpdb.ca/view/SMP0000335
    Signaling

    The H2 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Histamine H2 receptor
  5. Pathway

    Fc Epsilon Receptor I Signaling in Mast Cells

    smpdb.ca/view/SMP0000358
    Signaling

    Fc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies.

    Drugs: Heparin · Calcium · Magnesium cation · Zinc · Prostaglandin D2 · Arachidonic Acid
    Enzymes: Growth factor receptor-bound protein 2, High affinity immunoglobulin epsilon receptor subunit alpha
  6. Pathway

    Activation of PKC Through G Protein-Coupled Receptor

    smpdb.ca/view/SMP0000749
    Signaling

    IP3 can bind Ins3P receptor to open calcium channel by diffusion from cytoplasm to ER. Activated calcium channel will release the calcium from ER into cytoplasm.

    Drugs: Calcium
    Enzymes: Inositol 1,4,5-trisphosphate receptor type 1
  7. Pathway

    Intracellular Signalling Through PGD2 receptor and Prostaglandin D2

    smpdb.ca/view/SMP0000343
    Signaling

    The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream

    Drugs: ATP · Magnesium cation · Prostaglandin D2 · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Prostaglandin D2 receptor
  8. Drug

    Pulocimab

    go.drugbank.com/drugs/DB18938
    Investigational

    Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma).

    Synonyms: Immunoglobulin g1, anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ak109 .gamma.1-chain), disulfide with human monoclonal ak109 .kappa.-chain, dimer
  9. Drug

    Anti-CD5 CAR T-cell therapy

    go.drugbank.com/drugs/DB17279
    Investigational

    Synonyms: chimeric antigen receptor (CAR) directed against the target protein CD5
  10. Drug

    Inolimomab

    go.drugbank.com/drugs/DB15628
    Investigational

    Inolimomab is under investigation as an agent to treat steroid-resistant graft vs host disease. It has thus far offered similar efficacy to other monoclonal antibody options, though it may carry a higher risk of infections.

    Synonyms: Immunoglobulin G1, anti-(human interleukin 2 receptor alpha-chain) (mouse monoclonal B-B10 gammal-chain), disulfide with mouse monoclonal B-B10 kappa-chain, dimer