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Receptor-interacting serine/threonine-protein kinase 4
go.drugbank.com/bio_entities/BE0009533TargetHumansRequired for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity).
Polypeptides: Receptor-interacting serine/threonine-protein kinase 4Synonyms: Ankyrin repeat domain-containing protein 3Tyrosine-protein phosphatase non-receptor type 12
go.drugbank.com/bio_entities/BE0009940TargetHumansDephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).
Polypeptides: Tyrosine-protein phosphatase non-receptor type 12Tumor necrosis factor receptor superfamily member 6
go.drugbank.com/bio_entities/BE0010463TargetHumansReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 6Synonyms: FASLG receptorTumor necrosis factor receptor superfamily member 4
go.drugbank.com/bio_entities/BE0010535TargetHumansReceptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity
Polypeptides: Tumor necrosis factor receptor superfamily member 4Synonyms: OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptorTumor necrosis factor receptor superfamily member 10A
go.drugbank.com/bio_entities/BE0010564TargetHumansReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 10ASynonyms: Death receptor 4, TRAIL receptor 1Inactive tyrosine-protein kinase transmembrane receptor ROR1
go.drugbank.com/bio_entities/BE0010828TargetHumansVia IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068) … Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).
Polypeptides: Inactive tyrosine-protein kinase transmembrane receptor ROR1Synonyms: Neurotrophic tyrosine kinase, receptor-related 1Macrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansMembrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Scavenger receptor class A member 1, Macrophage acetylated LDL receptor I and IITriggering receptor expressed on myeloid cells 2
go.drugbank.com/bio_entities/BE0020451TargetHumansIn dendritic cells, receptor of SEMA6D with PLEXNA1 as coreceptor and mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). … Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849).
Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2T cell receptor beta variable 5-6
go.drugbank.com/bio_entities/BE0023691TargetHumansV region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).
Polypeptides: T cell receptor beta variable 5-6Ardeparin
go.drugbank.com/drugs/DB00407ApprovedWithdrawnArdeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500.