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Nofazinlimab
go.drugbank.com/drugs/DB18852InvestigationalNofazinlimab is under investigation in clinical trial NCT04194775 (A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma).
Synonyms: Recombinant pd-1 mab cs1003Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingIn the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells. … In the male the FSH receptor has been identified on the Sertoli cells that are critical for spermatogenesis.
Enzymes: Follicle-stimulating hormone receptorIntracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb.ca/view/SMP0000338SignalingLHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … The LHCGRs receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down
Enzymes: Lutropin-choriogonadotropic hormone receptorAnti-CD5 CAR T-cell therapy
go.drugbank.com/drugs/DB17279InvestigationalSynonyms: chimeric antigen receptor (CAR) directed against the target protein CD5Oritavancin
go.drugbank.com/drugs/DB04911ApprovedInvestigationalOritavancin is a glycopeptide antibiotic used for the treatment of skin infections. It was developed by The Medicines Company (acquired by Novartis). … [A39384,A193482,L8492] On March 12, 2021 the FDA approved Kimyrsa, a complete course of therapy in a single, 1 hour 1200 mg infusion.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseCarbamazepine
go.drugbank.com/drugs/DB00564ApprovedInvestigationalCarbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia.
Categories: P-glycoprotein inducers, P-glycoprotein substratesProducts: CARBAMAZEPIN 200 1A PHRetifanlimab
go.drugbank.com/drugs/DB15766ApprovedInvestigationalRetifanlimab is a humanized IgG4 kappa monoclonal antibody that binds to the programmed death receptor-1 (PD-1), blocking PD-1 interaction with its ligands, programmed death-ligand 1 (PD-L1) and programmed … On October 2021, Incyte Biosciences withdrew its application for a marketing authorization of retifanlimab for the treatment of squamous carcinoma of the anal canal.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitorsSynonyms: Anti-PD-1 monoclonal antibody MGA012Cupric sulfate
go.drugbank.com/drugs/DB06778ApprovedData from clinical observations of the neurotoxic effects of copper may provide the basis for future treatments affecting copper and its homeostasis [L1830]. … Copper is an essential trace element and an important catalyst for heme synthesis and iron absorption. After zinc and iron, copper is the third most abundant trace element found in the human body.
Mixtures: CALCIBON® MIN, Mega Min CapsulesTasimelteon
go.drugbank.com/drugs/DB09071ApprovedInvestigationalTasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). … In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and can lead to progressively delayed sleep onset.
Categories: Melatonin Receptor Agonists, Cytochrome P-450 SubstratesMAP kinase-activated protein kinase 5
go.drugbank.com/bio_entities/BE0009478TargetHumansTumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-...
Polypeptides: MAP kinase-activated protein kinase 5