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Lemborexant
go.drugbank.com/drugs/DB11951ApprovedInvestigational[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … [A189006,A189030] Whereas historically popular pharmacologic treatments for insomnia (e.g.
Categories: Orexin Receptor AntagonistsAtoltivimab
go.drugbank.com/drugs/DB15898ApprovedInvestigational[A221825, A221830] A recent large-scale study elucidated that both neutralizing and Fc-mediated functions of antibodies were important for therapeutic benefit in animal models of EBOV infection. … Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.
Categories: Treatments for Ebola Virus DiseasePioglitazone
go.drugbank.com/drugs/DB01132ApprovedInvestigational[A19759] Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due to the presence of multiple adverse effects and warnings regarding their use (e.g. congestive heart … failure, bladder cancer) and the availability of safer and more effective alternatives for patients with type 2 diabetes mellitus.
Categories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor Activity5-hydroxytryptamine receptor 4
go.drugbank.com/bio_entities/BE0000084TargetHumansG protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed
Polypeptides: 5-hydroxytryptamine receptor 4Synonyms: Serotonin receptor 4B-cell receptor CD22
go.drugbank.com/bio_entities/BE0000183TargetHumansActs as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation.
Polypeptides: B-cell receptor CD22Function: CD4 receptor bindingRetinoic acid receptor beta
go.drugbank.com/bio_entities/BE0000206TargetHumansReceptor for retinoic acid.
Polypeptides: Retinoic acid receptor betaSynonyms: Nuclear receptor subfamily 1 group B member 2Muscarinic acetylcholine receptor M5
go.drugbank.com/bio_entities/BE0000247TargetHumansThe muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action
Polypeptides: Muscarinic acetylcholine receptor M5Function: G protein-coupled acetylcholine receptor activityAlpha-2C adrenergic receptor
go.drugbank.com/bio_entities/BE0000342TargetHumansAlpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (...
Polypeptides: Alpha-2C adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C45-hydroxytryptamine receptor 2B
go.drugbank.com/bio_entities/BE0000393TargetHumansG protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600). … Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538, PubMed
Polypeptides: 5-hydroxytryptamine receptor 2BSynonyms: Serotonin receptor 2BSomatostatin receptor type 1
go.drugbank.com/bio_entities/BE0000452TargetHumansReceptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
Polypeptides: Somatostatin receptor type 1