Muscarinic acetylcholine receptor M5
Details
- Name
- Muscarinic acetylcholine receptor M5
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- CHRM5
- UniProtKB Entry
- P08912Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0010217|Muscarinic acetylcholine receptor M5 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
- Number of residues
- 532
- Molecular Weight
- 60073.205
- Theoretical pI
- 9.64
- GO Classification
- FunctionsG protein-coupled acetylcholine receptor activity / G protein-coupled serotonin receptor activityProcessesadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / chemical synaptic transmission / G protein-coupled acetylcholine receptor signaling pathway / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerComponentsdendrite
- General Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
- Specific Function
- G protein-coupled acetylcholine receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 30-53 67-87 105-126 147-169 192-214 444-464 479-498
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010218|Muscarinic acetylcholine receptor M5 (CHRM5) ATGGAAGGGGATTCTTACCACAATGCAACCACCGTCAATGGCACCCCAGTAAATCACCAG CCTTTGGAACGCCACAGGTTGTGGGAAGTCATCACCATTGCAGCTGTGACTGCTGTGGTA AGCCTGATCACCATTGTGGGCAATGTCTTGGTCATGATCTCCTTCAAAGTCAACAGCCAG CTCAAGACAGTTAACAACTATTACCTGCTCAGCTTAGCCTGTGCAGATCTCATCATTGGA ATCTTCTCCATGAACCTCTACACCACCTACATCCTCATGGGACGCTGGGCTCTCGGGAGT CTGGCTTGTGACCTTTGGCTTGCACTGGACTACGTGGCCAGCAACGCTTCTGTCATGAAC CTTCTGGTGATCAGTTTTGACCGTTACTTTTCCATCACAAGACCCTTGACATATCGGGCC AAGCGTACTCCGAAAAGGGCTGGCATCATGATTGGCTTGGCCTGGCTGATCTCCTTCATC CTCTGGGCCCCAGCAATCCTCTGCTGGCAGTACTTGGTTGGGAAGCGGACAGTTCCACTG GATGAGTGCCAGATCCAGTTTCTCTCTGAGCCCACCATCACTTTTGGCACTGCCATTGCT GCCTTCTACATCCCTGTTTCTGTCATGACCATCCTCTACTGTCGAATCTACCGGGAAACA GAGAAGCGAACCAAGGACCTGGCTGACCTCCAGGGTTCTGACTCTGTGACCAAAGCTGAG AAGAGAAAGCCAGCTCATAGGGCTCTGTTCAGATCCTGCTTGCGCTGTCCTCGACCCACC CTGGCCCAGCGGGAAAGGAACCAGGCCTCCTGGTCATCCTCCCGCAGGAGCACCTCCACC ACTGGGAAGCCATCCCAAGCCACTGGCCCAAGCGCCAATTGGGCCAAAGCTGAGCAGCTC ACCACCTGTAGCAGCTACCCTTCCTCAGAGGATGAGGACAAGCCCGCCACTGACCCTGTC CTCCAAGTGGTCTACAAGAGTCAGGGTAAGGAAAGCCCAGGGGAAGAATTCAGTGCTGAA GAGACTGAGGAAACTTTTGTGAAAGCTGAAACTGAAAAAAGTGACTATGACACCCCAAAC TACCTTCTGTCTCCAGCAGCTGCTCATAGACCCAAGAGTCAGAAATGTGTGGCCTATAAG TTCCGATTGGTGGTAAAAGCTGACGGGAACCAGGAGACCAACAATGGCTGTCACAAGGTG AAAATCATGCCCTGCCCCTTCCCAGTGGCCAAGGAACCTTCAACGAAAGGCCTCAATCCC AACCCCAGCCATCAAATGACCAAACGAAAGAGAGTGGTCCTAGTCAAAGAGAGGAAAGCA GCCCAGACACTGAGTGCCATTCTCCTGGCCTTCATCATCACATGGACCCCGTATAACATC ATGGTCCTGGTTTCTACCTTCTGTGACAAGTGTGTCCCAGTCACCCTGTGGCACTTGGGC TATTGGTTGTGCTATGTCAATAGCACTGTCAACCCCATCTGCTATGCCCTCTGCAACAGA ACCTTCAGGAAGACCTTTAAGATGCTGCTTCTCTGCCGATGGAAAAAGAAAAAAGTGGAA GAGAAGTTGTACTGGCAGGGGAACAGCAAGCTACCCTGA
- Chromosome Location
- 15
- Locus
- 15q14
- External Identifiers
Resource Link UniProtKB ID P08912 UniProtKB Entry Name ACM5_HUMAN GenBank Protein ID 177988 GenBank Gene ID M80333 GeneCard ID CHRM5 GenAtlas ID CHRM5 HGNC ID HGNC:1954 PDB ID(s) 6OL9 KEGG ID hsa:1133 IUPHAR/Guide To Pharmacology ID 17 NCBI Gene ID 1133 - General References
- Bonner TI, Young AC, Brann MR, Buckley NJ: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron. 1988 Jul;1(5):403-10. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Atropine approved, vet_approved yes target antagonist Details Homatropine methylbromide approved yes target antagonist Details Benzquinamide withdrawn yes target antagonist Details Promethazine approved, investigational unknown target antagonist Details Methotrimeprazine approved, investigational unknown target antagonist Details ALKS 27 investigational unknown target Details Nicardipine approved, investigational unknown target antagonist Details Quetiapine approved unknown target ligand Details Ziprasidone approved unknown target antagonist Details Clozapine approved unknown target antagonist Details Darifenacin approved, investigational unknown target antagonist Details Chlorprothixene approved, experimental, investigational, withdrawn no target antagonist Details Doxepin approved, investigational unknown target antagonist Details Desipramine approved, investigational no target antagonist Details Imipramine approved no target antagonist Details Brompheniramine approved unknown target antagonist Details Scopolamine approved, investigational yes target antagonist Details Trihexyphenidyl approved unknown target antagonist Details Solifenacin approved unknown target antagonist Details Maprotiline approved, investigational no target antagonist Details Tolterodine approved, investigational yes target antagonist Details Fesoterodine approved unknown target antagonist Details Aclidinium approved yes target antagonist Details Loxapine approved unknown target binder Details Terfenadine approved, withdrawn unknown target binder Details Umeclidinium approved unknown target antagonist Details Dosulepin approved yes target antagonist Details Gallamine triethiodide approved unknown target Details Tiotropium approved unknown target Details Homatropine approved yes target antagonist Details Propiverine approved, investigational yes target antagonist Details Thonzylamine approved unknown target antagonist Details Rociverine experimental yes target antagonist Details Aripiprazole lauroxil approved, investigational no target Details Aripiprazole approved, investigational unknown target ligand Details Methantheline approved, investigational yes target antagonist Details Methacholine approved, investigational unknown target agonist Details Bethanechol approved yes target agonist Details Glycopyrronium approved, investigational, vet_approved unknown target antagonist Details Pilocarpine approved, investigational yes target agonist Details Benactyzine withdrawn yes target antagonist Details Carboxyamidotriazole investigational yes target modulator Details Trospium approved yes target antagonist Details Promazine approved, vet_approved yes target binder Details Pramiracetam approved yes target modulator Details Emepronium experimental yes target modulator Details Butylscopolamine approved, investigational, vet_approved yes target modulator Details Mebeverine approved, investigational yes target antagonist Details Hyoscyamine approved yes target antagonist Details Procyclidine approved yes target antagonist Details Cyclopentolate approved yes target antagonist Details Flavoxate approved yes target antagonist Details Mepenzolate approved yes target antagonist Details Oxyphencyclimine approved yes target binder Details Tridihexethyl withdrawn yes target binder Details Anisotropine methylbromide approved yes target binder Details Prifinium experimental yes target modulator Details Choline alfoscerate experimental, investigational yes target modulator Details Cimetropium experimental, investigational yes target modulator Details Oxitropium investigational yes target modulator Details Aceclidine approved yes target inhibitor Details