Muscarinic acetylcholine receptor M5

BE0000247ProteinHumansCHRM5

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. It is acted on by 64 drugs in DrugBank.

Gene name
CHRM5
UniProtKB entry
P08912Swiss-Prot
Cellular location
Cell membrane
Residues / weight
532 residues · 60,073 Da

Resolves to

Protein
UniProtP08912UniProt nameACM5_HUMAN
Gene
HGNCHGNC:1954NCBI Gene1133GenBank177988GeneCardsCHRM5
Pharmacology
IUPHAR/GtoPdb17KEGGhsa:1133
Structure
PDB6OL9PDB9EK0
Drugs

What you can answer from here — as of September 07, 2019

64DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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107+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Muscarinic acetylcholine receptor M5, how selective are they, and which programs against it are still in active trials?

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