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Displaying results 1001 - 1010 of 10000 in total
  1. Target

    Leukocyte immunoglobulin-like receptor subfamily A member 4

    go.drugbank.com/bio_entities/BE0013620
    TargetHumans

    production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a … Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4
  2. Target

    C-type lectin domain family 10 member A

    go.drugbank.com/bio_entities/BE0016623
    TargetHumans

    Acts as a signaling receptor at the interface of APC-T cell interactions. … Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens

    Polypeptides: C-type lectin domain family 10 member A
  3. Target

    C-type lectin domain family 7 member A

    go.drugbank.com/bio_entities/BE0019143
    TargetHumans

    Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. … Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed

    Polypeptides: C-type lectin domain family 7 member A
  4. Drug

    Somatotropin

    go.drugbank.com/drugs/DB00052
    ApprovedInvestigational

    [A228183, L31508] Synthesized in a strain of _Escherichia coli_, recombinant HGH is a polypeptide hormone that contains 191 amino acid residues with a molecular weight of 22 kDa. … [A228188] Recombinant growth hormone is available as a subcutaneous injection for children and adults under a wide variety of brand names.

    Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InducersProducts: SciTropin A Solution for Injection 5 mg/1.5 ml, SciTropin A Solution for Injection 10 mg/1.5 ml
  5. Drug

    Polyethylene glycol

    go.drugbank.com/drugs/DB09287
    ApprovedInvestigationalVet approved

    PEGs have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative used to relieve occasional constipation. … Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.

    Mixtures: Gavilyte-N, DAXTELY FCategories: Compounds used in a research, industrial, or household setting, P-glycoprotein inhibitors
  6. Indication

    Not a candidate for enzyme replacement therapy

    go.drugbank.com/conditions/DBCOND0142182
    Drugs: Miglustat
    Synonyms: Not a candidate for enzyme replacement therapy
  7. Indication

    Bacterial infection due to streptococcus, group A

    go.drugbank.com/conditions/DBCOND0025102
    Drugs: Clavulanic acid
    Synonyms: Bacterial infection due to streptococcus, group A
  8. Indication

    Bleeding caused by Hemophilia A Without Inhibitor

    go.drugbank.com/conditions/DBCOND0170627
    Drugs: Fitusiran · Marstacimab
    Synonyms: Bleeding caused by Hemophilia A Without Inhibitor
  9. Indication

    Proteinuria caused by Primary Immunoglobulin A Nephropathy

    go.drugbank.com/conditions/DBCOND0168683
    Drugs: Sibeprenlimab
    Synonyms: Proteinuria caused by Primary Immunoglobulin A Nephropathy
  10. Indication

    Not a candidate for non-estrogen therapy

    go.drugbank.com/conditions/DBCOND0126009
    Drugs: Estradiol
    Synonyms: Not a candidate for non-estrogen therapy