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Displaying results 1001 - 1010 of 10000 in total
  1. Target

    Leukocyte immunoglobulin-like receptor subfamily A member 4

    go.drugbank.com/bio_entities/BE0013620
    TargetHumans

    Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354 … production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4
  2. Target

    C-type lectin domain family 10 member A

    go.drugbank.com/bio_entities/BE0016623
    TargetHumans

    Acts as a signaling receptor at the interface of APC-T cell interactions. … Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens

    Polypeptides: C-type lectin domain family 10 member A
  3. Target

    C-type lectin domain family 7 member A

    go.drugbank.com/bio_entities/BE0019143
    TargetHumans

    Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. … Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed

    Polypeptides: C-type lectin domain family 7 member A
  4. Drug

    Nitrogen

    go.drugbank.com/drugs/DB09152
    ApprovedInvestigationalVet approved

    Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas.

    Mixtures: OXIMED CLINAPAL®, Oxygen W NitrogenProducts: N/A
  5. Drug

    Ethanol

    go.drugbank.com/drugs/DB00898
    ApprovedInvestigational

    A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. … It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.

    Synonyms: 1-HydroxyethaneMixtures: Nox-A-Sting, Soothe-A-sting
  6. Drug

    Hyaluronidase

    go.drugbank.com/drugs/DB14740
    ApprovedInvestigational

    [A199026] Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue. … [A199047] Hyaluronidase was first used in prescription products in the United States on 5 May 2004.[L13338]

    Products: POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION PARA ADMINISTRACIÓN OFTALMICA, HYLASE® DESSAU 150 IU
  7. Drug

    Bivalirudin

    go.drugbank.com/drugs/DB00006
    ApprovedInvestigational

    Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.

    Products: ANGIOMAX® POLVO LIOFILIZADO PARA RECONSTRUIR A SOLUCIÓN INYECTABLE (50MG/ML), OBIVADIN 250 MG IV ENJEKSIYON/INFÜZYON IÇIN LIYOFILIZE TOZ, 1 ADET
  8. Drug

    Pasireotide

    go.drugbank.com/drugs/DB06663
    ApprovedInvestigational

    Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.

    Synonyms: cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-)International brands: Signifor LAR
  9. Drug

    Dupilumab

    go.drugbank.com/drugs/DB12159
    ApprovedInvestigational

    [L7186] Dupilumab is commonly marketed as Dupixent, which is available as a formulation for subcutaneous injection. It was first approved by the FDA in 2017. … Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways.

    Categories: Interleukin-4 Receptor alpha Antagonist, Interleukin 4 Receptor alpha AntagonistsProducts: DUPIXENT SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 300 mg/2ml, DUPIXENT SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 200 mg/1.14ml
  10. Indication

    Invasive Meningococcal Disease caused by Neisseria meningitidis serogroup A

    go.drugbank.com/conditions/DBCOND0165273
    Drugs: Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine · Meningococcal polysaccharide vaccine group A · Neisseria meningitidis group A capsular polysaccharide tetanus toxoid conjugate antigen · Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen
    Synonyms: Invasive Infection caused by Neisseria meningitidis serogroup A, Invasive Meningococcal Disease caused by Neisseria meningitidis serogroup A