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Displaying results 1021 - 1030 of 2256 in total
  1. Drug

    Ribociclib

    go.drugbank.com/drugs/DB11730
    ApprovedInvestigational

    These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali.

  2. Drug

    Thiotepa

    go.drugbank.com/drugs/DB04572
    ApprovedInvestigational

    N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years.

  3. Drug

    Activated charcoal

    go.drugbank.com/drugs/DB09278
    ApprovedInvestigational

    It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity for various substances

  4. Drug

    Etoperidone

    go.drugbank.com/drugs/DB09194
    ApprovedWithdrawn

    Etoperidone is an atypical antidepressant introduced in Europe in 1977. It is a phenylpiperazine-substituted triazole derivative with a composition that classifies it as an analog of tradozone and presents a similar pharmacological profi...

    Categories: Serotonin Receptor Antagonists, Serotonin 5-HT2 Receptor Antagonists
  5. Drug

    Cetylpyridinium

    go.drugbank.com/drugs/DB11073
    ApprovedInvestigational

    Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic properties. Its salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, ...

  6. Drug

    Clodronic acid

    go.drugbank.com/drugs/DB00720
    ApprovedInvestigationalVet approved

    [A1923] clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid]

  7. Target

    G protein-coupled receptor kinase 3

    go.drugbank.com/bio_entities/BE0000018
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). … Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898).

    Polypeptides: G protein-coupled receptor kinase 3Synonyms: Beta-adrenergic receptor kinase 2
  8. Target

    Vascular endothelial growth factor receptor 1

    go.drugbank.com/bio_entities/BE0000029
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival

    Polypeptides: Vascular endothelial growth factor receptor 1Synonyms: Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor
  9. Target

    Sigma non-opioid intracellular receptor 1

    go.drugbank.com/bio_entities/BE0000156
    TargetHumans

    Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity)

    Polypeptides: Sigma non-opioid intracellular receptor 1Synonyms: Sigma1-receptor, Sigma 1-type opioid receptor
  10. Target

    Scavenger receptor class B member 1

    go.drugbank.com/bio_entities/BE0000189
    TargetTransporterHumans

    May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218) … Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).

    Polypeptides: Scavenger receptor class B member 1Synonyms: Collagen type I receptor, thrombospondin receptor-like 1