Sigma non-opioid intracellular receptor 1

BE0000156ProteinHumansSIGMAR1

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. It is acted on by 33 drugs in DrugBank.

Gene name
SIGMAR1
UniProtKB entry
Q99720Swiss-Prot
Cellular location
Nucleus inner membrane
Residues / weight
223 residues · 25,128 Da
Also known as
Aging-associated gene 8 protein · hSigmaR1 · OPRS1 · SIG-1R · Sigma 1-type opioid receptor

Resolves to

Protein
UniProtQ99720UniProt nameSGMR1_HUMAN
Gene
HGNCHGNC:8157NCBI Gene10280GenBank1783387GeneCardsSIGMAR1
Pharmacology
IUPHAR/GtoPdb2552KEGGhsa:10280
Structure
PDB5HK1PDB5HK2PDB6DJZ
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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103+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sigma non-opioid intracellular receptor 1, how selective are they, and which programs against it are still in active trials?

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