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Filgrastim
go.drugbank.com/drugs/DB00099ApprovedInvestigational[A245858] Tbo-filgrastim was approved by the FDA on August 29, 2012.[L36325] Filgrastim-sndz was approved on March 6, 2015 [L40768] and filgrastim-ayow was approved on March 2, 2022. … [L40714] Human G-CSF is a glycoprotein that regulates the production and release of neutrophils from the bone marrow.
Synonyms: r-metHuG-CSFInternational brands: White-CEntecavir
go.drugbank.com/drugs/DB00442ApprovedInvestigationalEntecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine … Food and Drug Administration (FDA) in March 2005.
Categories: Hepatitis B virus, Cytochrome P-450 SubstratesProducts: ENTECAVIR HEU 1 MG FTA, ENTECAVIR AL 1MGVincristine
go.drugbank.com/drugs/DB00541ApprovedInvestigationalVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. … because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Mixtures: MEODEX®, MEODEX®Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexCamphor
go.drugbank.com/drugs/DB01744ApprovedInvestigationalWithdrawnThe FDA ruled that camphorated oil could not be marketed in the United States and that no product could contain a concentration higher than 11%. … Camphor is a bicyclic monoterpene ketone found widely in plants, especially _Cinnamomum camphora_. It is used topically as a skin antipruritic and as an anti-infective agent.
Synonyms: (+)-bornan-2-one, (R)-camphorMixtures: Pain-A-trate Cream, Antiphlogistine Rub A 535 Extra StrengthUndecylenic acid
go.drugbank.com/drugs/DB11117ApprovedIt is used as a precursor in the manufacture of aromatic chemicals, polymers or modified silicones [L1891]. … Due to its bifunctional properties, undecylenate is also used as a linking molecule to conjugate other biomolecules such as proteins. It serves as an acid moiety for anabolic steroid boldenone.
Mixtures: NEOFUNGINA® POLVO, NEOFUNGINA® POLVOProducts: Myco Nail A Antifungal Solution, Hongocura MLeflunomide
go.drugbank.com/drugs/DB01097ApprovedInvestigationalLeflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. … Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Synonyms: 4-ISOXAZOLECARBOXAMIDE, 5-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesMorphine
go.drugbank.com/drugs/DB00295ApprovedInvestigational[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. … [A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diolSolifenacin
go.drugbank.com/drugs/DB01591ApprovedInvestigational[L7511] It has a long duration of action as it is usually taken once daily.[L7511] Solifenacin was granted FDA approval on 19 November 2004.[L7511] … Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency.
Mixtures: VESOMNI®, VESOMNİ 6 MG/0.4 MG DEĞİŞTİRİLMİŞ SALIMLI TABLET, 30 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesAzathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigationalAzathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic … [L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurineLoperamide
go.drugbank.com/drugs/DB00836ApprovedInvestigational[A251610] Loperamide has a chemical structure that is similar to diphenoxylate and haloperidol;[A6249] however, loperamide works on mu (μ)-opioid receptors to mediate its pharmacological actions. … [A251610] It is a highly lipophilic synthetic phenylpiperidine opioid that works by binding to mu-opioid receptors on intestinal muscles to decrease intestinal motility and electrolyte loss.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: A D, Imodium A-D