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Alfuzosin
go.drugbank.com/drugs/DB00346ApprovedBenign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. … The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over 70.
Synonyms: (±)-N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furamide, N-[3-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)- methyl-amino]propyl] tetrahydrofuran- 2-carboxamideCategories: Genito Urinary System and Sex Hormones, Cytochrome P-450 SubstratesIntermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizure
go.drugbank.com/conditions/DBCOND0120023Drugs: DiazepamSynonyms: Intermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizureRabeprazole
go.drugbank.com/drugs/DB01129ApprovedInvestigationalRabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. … Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Categories: Cytochrome P-450 Substrates, 2-PyridinylmethylsulfinylbenzimidazolesProducts: Ag-rabeprazole, Raberprazole Sodium D/rFulvestrant
go.drugbank.com/drugs/DB00947ApprovedInvestigationalFulvestrant is a drug treatment of hormone receptor (HR)-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. … While it is used as monotherapy for the treatment of breast cancers, it is also used in combination with [alpelisib] for the treatment of HR-positive, human epidermal growth factor receptor 2 (HER2)-negative
Synonyms: (7α,17β)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diolCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. … Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP1A1 SubstratesProducts: Fluvastatin Sodium ER, FLUVASTATINA EGValproic acid
go.drugbank.com/drugs/DB00313ApprovedInvestigational[A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. … a similar degree of anticonvulsive activity.
Synonyms: 2-n-propyl-n-valeric acid, n-DPACategories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexPseudoephedrine
go.drugbank.com/drugs/DB00852ApprovedPseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system. … [A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889.
Synonyms: d-psi-2-Methylamino-1-phenyl-1-propanol, (+) threo-2-(methylamino)-1-phenyl-1-propanolMixtures: Ed-A-hist Pse, ACTIGRIP GIORNO & NOTTECalcium acetate
go.drugbank.com/drugs/DB00258ApprovedIt has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.
Mixtures: DOMEBORO® POLVO, DALIDOMEPOLVO SACHET 2.2 GCategories: Compounds used in a research, industrial, or household setting, ascorbic acid (vit C) and calciumSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
go.drugbank.com/bio_entities/BE0003750TargetHumansThe PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed … Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147).
Polypeptides: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformSynonyms: PP2A subunit A isoform R1-alpha, PP2A subunit A isoform PR65-alpha