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Displaying results 1061 - 1070 of 10000 in total
  1. Drug

    Water

    go.drugbank.com/drugs/DB09145
    ApprovedInvestigational

    Water is a liquid at standard ambient temperature and pressure, but it often co-exists on Earth with its solid state, ice; and gaseous state, steam (water vapor). … As a chemical compound, a water molecule contains one oxygen and two hydrogen atoms that are connected by covalent bonds.

    Mixtures: K-Mart SmartSense First Aid Contains 101 Pieces, K-Mart SmartSense First Aid Contains 303 PiecesProducts: N/A, Dorama-Neo
  2. Drug

    Chloroprocaine

    go.drugbank.com/drugs/DB01161
    ApprovedInvestigational

    Both can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks. … [L43402] The pharmacological profile of chloroprocaine is characterized by a short latency and duration, similar to the one observed with [lidocaine].

    Synonyms: 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate, 4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl esterProducts: Nesacaine Ce 2% Inj 20mg/ml, Nesacaine Ce 3% Inj 30mg/ml
  3. Target

    Chymase

    go.drugbank.com/bio_entities/BE0001038
    TargetHumans

    Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion

    Synonyms: Mast cell protease I
  4. Target

    Glutamate--cysteine ligase

    go.drugbank.com/bio_entities/BE0001738
    TargetEscherichia coli (strain K12)

    Synonyms: gsh-I
  5. Target

    Nitric oxide synthase

    go.drugbank.com/bio_entities/BE0010197
    TargetEnzyme

    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. … Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832).

    Synonyms: NOS type I, Inducible NO synthase
  6. Drug

    Trametinib

    go.drugbank.com/drugs/DB08911
    ApprovedInvestigational

    Originally developed by Japan Tobacco, trametinib was initially investigated for treating inflammation, but further studies for this indication were not pursued.[A258298] … [A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the European Commission on June 30, 2014.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesProducts: MEKINIST®2 MG TABLETAS RECUBIERTAS, MEKINIST 2 MG FILM KAPLI TABLET ,7 TABLET
  7. Drug

    Pectin

    go.drugbank.com/drugs/DB11158
    ApprovedInvestigationalVet approved

    [L1961] The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or as acid amides. … Under the FDA regulation, pectin qualifies as a GRAS (generally recognized as safe) food substance. This status allows pectin to be used with no limitations.[L1960]

    Mixtures: Diban Cap, Diban CapCategories: Compounds used in a research, industrial, or household setting
  8. Target

    Angiotensin-converting enzyme

    go.drugbank.com/bio_entities/BE0000221
    TargetEnzymeHumans

    Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation … Degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) and amyloid-beta proteins is mediated by the N-terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the

    Synonyms: Dipeptidyl carboxypeptidase I
  9. Drug

    Vildagliptin

    go.drugbank.com/drugs/DB04876
    ApprovedInvestigational

    [L32813] Vildagliptin is currently under investigation in the US. … [A232488] Oral vildagliptin was approved by the European Medicines Agency in 2008 for the treatment of type II diabetes mellitus in adults as monotherapy or in combination with [metformin], a sulfonylurea

    Mixtures: GALVUS® MET 50/500 COMPRIMIDOS RECUBIERTOS CON PELICULA, GALVUS® MET COMPRIMIDO RECUBIERTO CON PELICULA 50 MG/850 MGCategories: DPP-IV Inhibitors, Drugs Used in Diabetes
  10. Target

    DNA ligase 1

    go.drugbank.com/bio_entities/BE0000199
    TargetHumans

    DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination

    Synonyms: DNA ligase I