Angiotensin-converting enzyme

BE0000221ProteinHumansACE

Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or... It is acted on by 58 drugs in DrugBank.

Gene name
ACE
UniProtKB entry
P12821Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,306 residues · 149,714 Da
Also known as
3.4.15.1 · ACE · DCP · DCP1 · Dipeptidyl carboxypeptidase I

Resolves to

Protein
UniProtP12821UniProt nameACE_HUMAN
Gene
HGNCHGNC:2707NCBI Gene1636GenBank178286GeneCardsACE
Pharmacology
IUPHAR/GtoPdb1613KEGGhsa:1636
Structure
PDB1O86PDB1O8APDB1UZE
Drugs

What you can answer from here — as of September 07, 2019

58DrugsApproved to experimental, with action, bond type and pharmacological action
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20Clinical trialsTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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245+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Angiotensin-converting enzyme, how selective are they, and which programs against it are still in active trials?

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